Haa, Heerkaaga CRP waa Sare. Hadda maxaa?
Dhaqtarkaagu ma qiyaasay heerkaaga C-reactive-ka (CRP), oo aad ka heshay in ay sare u kacdo? Tani waa xaalad caadi ah oo sii kordhaysa, inkastoo xaqiiqda ah in khubarada badankoodu aysan kugula talineynin in si joogto ah loo cabbiro heerarka CRP.
CRP waa biomarker-yare aan dabiici ahayn. Taasi waa, marka heerarka CRP ay sare u kacaan, taasi waa calaamad muujinaysa in caabuqu uu ku dhaco meel jidhka ka mid ah.
Sidaa darteed, tusaale ahaan, haddii aad qabto infekshin ama ficil firfircoon, heerkaaga CRP ayaa u muuqda mid sareeya.
Si kastaba ha noqotee, waxa soo baxday in marka heerarka CRP ay si joogta ah u sarreeyaan dadka caafimaadka leh ee aan lahayn calaamadaha caabuq firfircoon, taasi waxay noqon kartaa calaamad muujinaysa in caabuq daba-galka ah oo uu maro xididada dhiiga. Nooca nooca hooseeya ee infektionasku wuxuu ka qayb qaataa cudurka wadnaha.
- Akhriso waqtiga goorta laguu cabbiro CRP-gaaga .
Hadda maxaa?
Waxay u badan tahay in aad la yaabi karto, ama xitaa walaacsan tahay, adoo helaya in CRP-gaagu sarreeyo. Nasiib darro, waxaa macquul ah in dhakhtarkaaga uu sidoo kale ka walwalsan yahay waxa la samaynayo marka xigta - tan iyo "waxa la samaynayo" ee maaha mid toos ah.
Inkastoo ay hadda si fiican u aasaaseen in caabuqu yahay mid muhiim u ah atherosclerosis , iyo in kor loo qaado CRP (taas oo ah calaamad muujinaysa caabuq) waxay la xiriirtaa khatarta sii kordhaysa ee cudurka halbowlaha wadnaha (CAD) , lama ogaan karo haddii CRP lafteeda ay caawineyso CAD, ama haddii daaweynta loogu talagalay gaar ahaan hoos u dhigidda heerarka CRP waxay yareysaa khatarta wadnaha.
Marka, marka CRP-daagu uu sarreeyo khatarta aad u leedahay inuu horumariyo CAD wuxuu kaloo ka sareeyaa sida ay tahay. Laakiin ma hubno inta ay runtii ka caawineyso in la qaado tallaabooyinka loogu talagalay gaar ahaan hoos u dhigista heerarkaaga CRP. Taas, waxa loo baahan yahay in la sameeyo waa inaad qaadato fursad kasta oo aad leedahay si loo yareeyo halista guud ee wadnaha.
Maxay Tahay Inuu Ku Dhaco
Hadda oo aad taqaanid CRP-gaaga aad u sarreeya, waxaa jira laba su'aalood oo aad weydiineyso.
1) Waa maxay waxyaabaha kale ee khatarta ah?
Heerarka sare ee CRP waxaa inta badan lala xiriiriyaa arrimaha kale ee halista ah ee cudurka wadnaha.
Kuwaas waxaa ka mid ah sigaar-cabista, cayilku, hab-nololeedka dabiiciga ah, kor u kaca kolesteroolka , hypertension iyo cudurrada dheef-shiid kiimikaadka . Dhibaatooyinkaas oo dhan waxay yihiin kuwo aad u muhiim ah, adiga iyo dhakhtarkaaga ayaa awood u leh inay helaan dhammaantood iyaga oo koontaroolaya.
Sidaa darteed, wax kasta oo adiga iyo dhakhtarkaagu go'aansan inaad ka qabtaan CRP laftiisa, leh CRP sareeya waxay ka dhigeysaa mid aad uga muhiimsan in la qaado tallaabooyin dagaal badan si loo yareeyo dhammaan waxyaabha halista wadnaha .
2) Sidee baan u yareeyn karaa heerka CRP-ga?
Inkastoo aysan weli hubin sida ay muhiimka u tahay in la yareeyo heerarka CRP-ga sareeya, dhowr siyaabood oo lagu yareeynayo CRP ayaa loo aqoonsaday:
Hababka aan dawooyinka lahayn ee yareynaya CRP waxaa ka mid ah jimicsiga aerobic, joojinta sigaarka , miisaan lumis iyo cunto caafimaad leh oo caafimaad leh . Si kale haddii loo dhigo, qaadashada talaabooyin xooggan si loo sameeyo caafimaadkaaga qaab nololeedkaaga ayaa sidoo kale keenaya hoos udhaca CRP.
Daaweynta mukhaadaraadka waxay sidoo kale yareyn kartaa CRP . ** Statins ** Waxay hoos u dhigtaa heerarka CRP si aad ah (13 ilaa 50%,) iyada oo loo eegayo tijaabooyin dhowr ah.
Lipitor (Atorvastatin), Mevacor (lovastatin), Pravachol (pravastatin), Crestor (rosuvastatin) iyo Zocor (simvastatin) ayaa dhamaantood lagu soo bandhigay inay hoos u dhigaan heerka CRP waxayna muujiyeen caddayn yareynta halista wadnaha iyada oo loo marayo CRP (oo ka soo horjeeda kolesteroolka) . Sidoo kale, tijaabada JUPITER ayaa si cad u muujisay in bukaanlayda leh heerarka CRP-da "laakiin" heerka caadiga ah "kolestaroolka," Crestor "oo si weyn u yaraada iyo khatarta dhimista wadnaha.
Inkastoo aspirin aysan yareeynin heerarka CRP, dadka qaba heerarka CRP waxay sare u qaadaan faa'idoyin ka-yareeya hoos-u-dhaca ka yimaadda aspirin marka loo eego kuwa caadiga ah ee CRP caadiga ah.
Marka heerarka sare ee CRP waxay tilmaamaan qiyaasaha daaweynta aspirin ee daaweynta qaar ka mid ah.
Akhriso wax dheeraad ah oo ku saabsan cidda qaadanaysa daawada aspirin .
Ereyga
Wali lama garankara haddii CRP lafteedu kordhiso khatarta wadnaha, ama haddii ay kaliya ka tarjumayso dhaawaca dhiigga iyo bararka oo keena waxyaabo kale oo halis ah. Sidaa darteed haddii heerarkaaga CRP ay sare u qaadaan, waa inaad taas u qaadataa sida calaamad muhiim ah oo ay tahay waqtigii lagu qaadi lahaa khatarta ku saabsan dhimista dhammaan cudurrada halista wadnaha adigoo jimicsiga, ma cabin sigaarka, miisaanka oo lumiya, daawashada cuntadaada, iyo xakamaynta cadaadiska dhiiggaaga.
Si kastaba ha ahaatee, waxay hadda u muuqataa in isticmaalka daroogooyinka statin ay si weyn hoos ugu dhigi karaan halista wadno-qabadka wadnaha iyo istaroogga xitaa dadka bukaanka ah ee caafimaadkooda muuqda oo heerkooda CRP ay sarreeyaan.
Haddii aad qabtid heerar sare CRP, gaar ahaan haddii aad leedahay hal ama dhowr waxyaabood oo dheeraad ah oo ku saabsan cudurada wadnaha, waa inaad kala hadashaa ikhtiyaarka daawada takhtarkaaga dhakhtarkaaga.
> Ilo:
> Iskuduwaha Khatarta Halista Soo Saaraya, Kaptoge S, Di Angelantonio E, iyo al. C-reactive Concentration iyo Khatarta Cudurka Wadnaha ee Wadnaha, Stroke, iyo Dhimashada: falanqayn farsamo ee kaqaybgalayaasha shakhsiga ah. Lancet 2010; 375: 132.
> Hingorani AD, Sofat R, Morris RW, et al. Miyuu Muhiim u Yahay In Loo Hormariyo ama Yaree Cudurka C-Reaktitka Dadka Dhibaatada Cudurada Wadnaha Dhiigga ah? Eur Heart J 2012; 33: 2258.
> Ridker PM, Danielson E, Fonseca FA et al. Rosuvastatin si looga hortago dhacdooyinka Vascular ee Ragga iyo dumarka leh C-reaktive Protein. New Engl J Med 2008; DOI: 10.1056 / NEJMoa0807646.
> Qeybo PS, Poulter NR, Chang CL, et al. Qiimeynta Protein C-reactive Priorin Ka hor iyo Daaweeynta sida Predictor of Benefit ka Atorvastatin: Indho-indhaynta laga bilaabo tijaabinta Natiijada Wadnaha ee Anglo-Scandinavian. Eur Heart J 2012; 33: 486.