Qeybta 2 ee 3
Sida aan ka baranay qaybta mid ka mid ah, Waa maxay Mawduuca Bannaanka Kadib, dadka qaba daal daba-dheeraadka ah ( ME / CFS ) waxay u arkaan inta badan calaamadaha soo noqnoqda ee calaamadaha soo noqnoqda. Tani waa calaamad muujinaysa cudurka iyo mid ka mid ah cilmi-baarayaashu waxay isku dayayeen in ay ogaadaan sanado badan. Weli wax badan ayaan ka ogaan karnaa calaamadahan, laakiin waxaan ognahay in isku dheelitirnaanta jireed ee badani ay ku xiran tahay khaladaadka ka dambeeya (PEM).
Dhibaatooyinka Jidhka
Cilmi-baadhayaashu waxay aqoonsadeen isbeddelka jimicsiga ee nidaamyo kala duwan, oo ay ku jiraan habka difaaca jidhka, habka dhexe ee dareenka, iyo nidaamka wadnaha. Si kastaba ha ahaatee, si kastaba ha ahaatee, ma aysan awoodin in ay soo gabagabeeyaan in cilladahaasi yihiin sababaha (P) ee PEM. Dib-u-eegis 2014 ah ee suugaanta caafimaad ayaa lagu ogaaday in jawaabaha habka difaaca jirka ee la beddelay ee ME / CFS, kuwaas oo intooda badan lagu xiri jiray jimicsi iyo PEM. Kuwaas waxaa ka mid ah:
- Jawaab badan oo lagu qeexay nidaamka isku dhafan (qayb ka mid ah habka difaaca jidhka oo kaa caawinaya jiritaanka jirka jirkaaga),
- Kororka diiqadda oxidative (nooc ah dhaawac maskaxeed) oo ay weheliso jawaab celin xun oo ka hortag ah antioksidant,
- Isbeddel ku yimaada unugyada difaaca jirka 'profile profile.
Cilmi-baadhisto kale (Morris 2014) ayaa baaray waxyaabo aan caadi ahayn oo la xidhiidha walax la yiraahdo adenosine triphosphate (ATP), oo ah nooc ka mid ah tamarta gacanta. ME / CFS waxaa la aaminsan yahay in ay la xiriirto awoodda naafanimada ah si loo abuuro ATP heerka heerka mitirka.
(Mitochondria waa qaabab ku jira unugyadaada kuwaas oo beddelaya nafaqooyinka galay ATP.)
Daraasada 2015-ka iyadoo la isticmaalayo qaabka kombiyuutarka ee cudurku (Lengert) wuxuu eegay heerar aad u hooseeya oo ATP ah, kaas oo caadi ahaan keeni lahaa dhimashada heerka dhimashada. Tilmaamaha silsiladda oo ka bilaabanaya ATP hooseeya waxay keentay dysregular immunojiyadeed iyo cadaadiska oksidheer, sida ku cad tusaalaha.
Cilmi-baadhayaasha ayaa sheegaya in dhaqdhaqaaqyo soo noqnoqday ay xaaladdoodu aad u xun tahay. Sannadkii 2012, waraaq muujinaysa shaqada mitochondrial iyo ME / CFS (Morris) ayaa ka hadlay waxyaabo badan oo aan caadi ahayn, oo ay ka mid yihiin:
- Wadooyinka loo yaqaan 'immuno-inflammatory pathways'
- Heerarka sare ee cyokokine pro- blaming ,
- Heerarka heerarka nukliyeerka-kB,
- Xakameynta shaqooyinka mitochondrial, oo ay ku jiraan wax soo saarka hooseeya ee ATP.
Cilmi-baadhayaashu waxa ay ku doodeen in arrimahan ay ugu yaraan qayb ahaan, ay u horseedi karaan diiqad mitirka ah, taas oo macnaheedu yahay marka jirku dalbanayo tamar (qaab ATP), tamarta si fudud maaha.
Daraasad kale oo 2015-ka ah ayaa la isticmaalay nooc ka mid ah baarista lagu magacaabo spectroscopy oo u dhow-wareega si loo cabbiro isticmaalka oksijiinta inta lagu jiro jimicsiga sahlan. Marka loo barbardhigo dadka caafimaadka qaba ee kooxda xakameynaya, kaqeybgalayaasha ME / CFS waxaa lagu ogaadey inay yeeshaan isbeddel aan caadi ahayn oo ku yimaada oxygenation of hemoglobin (borotiin ku jirta unugyada dhiigga cas (red oxygen) ee unugyadaada ka dib markaad jimicsanaysid.
Wax kasta oo isku dhafan oo ka mid ah arrimahan ayaa si macquul ah ugu biiri kara PEM. Weli, cilmi-baarayaashu waxay leeyihiin shaqo badan ka hor. Qaar ka mid ah cilmi-baarayaasha ayaa soo jeediyay in qaar ka mid ah cilladaha qaarkood loo isticmaali karo calaamad ujeedo qeexan oo loogu talagalay ME / CFS halka kuwa kale ay aaminsan yihiin in PEM ay noqon karto hab wax ku ool ah oo dhakhtaradu u cabbiraan darnaanta jirrada.
Muhiimad ahaan, wax badan oo aan ka ogaanno waxa socdaalka jirka ku jira inta lagu jiro PEM, waan ku dhawahay inaan fahamno sida loo daaweyn lahaa.
Wax dheeri ah baro
Ilaha:
Lengert N, Drossel B. Chemistry Biophysical. 2015 Jul 202: 21-31. Falanqaynta silico ee dulqaad la'aanta jimicsiga ee encephalomyelitis / dareen-daba-xannuun daba-dheeraaday.
Miller RR, et al. Wargeyska daawada tarjumaadda. 2015 May 20; 13: 159. Imtixaanka jimicsiga submaximal ah ee la socota fayruska kudhaca curiyaha korontada ee encephalomyelitis / bukaanka dareenka daba dheeraaday marka la barbardhigo kantaroolid caafimaad leh: daraasad kayska la xakameynayo.
Morris G, Maes M. Muuqaal Caafimaad. 2012 Nov; 79 (5): 607-13. Kobcinta nukliyeerka-kB iyo lumitaanka p53 waa farsamooyinka muhiimka ah ee encephalomyelitis / daal daba-dheeraaday (ME / CFS).
Morris G, Maes M. Cudurka maskaxda ee maskaxda. 2014 Mar; 29 (1): 19-36. Mitochondrial disorders in myalgic encephalomyelitis / ciladda dareenka daba dheeraadka ah ee lagu sharraxay habka firfircoon ee loo yaqaan 'immuno-inflammatory activated, oxidative and stroke pathways'.
Nijs J, Nees A, et al. Dib-u-eegis xagga jimicsiga. 2014; 20: 94-116. Jawaabta difaaca ee la beddelay ee jimicsiga bukaanka qaba dareen dufanka dabadheeraad ah / enalphalomyelitis myalgic: dib u eegis suugaan nidaamsan.