Rasuullada Molekular
Cytokines waxay u adeegaan sidii farriimo jajab ah oo u dhexeeya unugyada. Cytokines waa borotiino ay soo saaraan unugyo. Marka la eego arthritis-ka, cyokokines waxay nidaamiyaan jawaabaha kala duwan ee bararka . Cytokines waxay la macaamilaan unugyada habka difaaca jirka si loo xakameeyo jawaabaha jidhka ee cudurka iyo caabuqa, iyo sidoo kale dhexdhexaadinta hababka caadiga ah ee unugyada jidhka.
Noocyada Cytokines
Cytokines waa noocyo kala duwan, taas oo micnaheedu yahay dhammaantood ma ahan kuwo isku mid ah. Cytokines waxay qabtaan hawlaha kala duwan ee jirka:
- saameynta kicinta colony (kicinta wax soo saarka unugyada dhiiga)
- kobcinta iyo isdhaafsiyada kala duwan (waxqabadka ugu muhiimsan ee horumarinta, dayactirka unugyada, iyo dayactirka)
- cytokines (immunoregulatory and proinflammatory cytokines) (sida, interferons, interleukins, iyo TNF-alpha kuwaas oo shaqeynaya nidaamka difaaca jirka)
Iyadoo "cytokines" waa dallad ay ku jiraan dhammaan noocyada, waxaa jira magacyo cayiman oo la siiyo cyokokines iyada oo ku saleysan nooca unugyada iyaga ka dhigaya ama ficilka ay ku hayaan jirka:
- Lymphokines (oo ay sameeyeen lymphocytes)
- monokines (oo ay sameeyeen monocytes)
- chemokines (oo la xidhiidha ficilo chemotactic)
- interleukins (oo ay sameeyeen hal leukocyte laakiin waxay u dhaqmaan xajka kale ee leukocytes)
Sidee Cytokines u shaqeeyaan
Nidaamka difaaca ayaa ah mid adag - noocyada kala duwan ee unugyada difaaca jirka iyo borotiinku waxay qabtaan shaqooyin kala duwan. Cytokines waxay ka mid yihiin bakteeriyadaas.
Sharaxaadda sida ay u shaqeeyaan cytokines way adag tahay. Waa cashar ku saabsan jiridda unugyada. Laakiin, si aad u fahamtid caabuq, waa inaad fahamtaa doorka cytokines ciyaaraan.
Cytokines waxaa lagu sii daayaa unugyada wareegga wareegga ama si toos ah loogu soo saaro unug. Cytokines waxay helayaan unugyada difaaca jirka ee la beegsanayo waxayna la falgalaan kuwa soo dhaweeyaha ee unugyada difaaca jirka ee la beegsanayo iyaga oo ku xiraya iyaga.
Is-dhexgalka ayaa kiciya ama kiciya jawaabaha gaarka ah ee unugyada bartilmaameedka.
Kordhinta waxtarka Cytokines
Hoos-u-dhiska ama wax-soo-saarka aan habooneyn ee cytokines gaar ah oo jirka ah ayaa sababi kara cudur. Tusaale ahaan, waxaa la ogaadey in interleukin-1 (IL-1) iyo burqanimada necrosis factor-alpha (TNF-alpha) lagu soo saaro xad-dhaaf ah rheumatoid arthritis halkaasoo ay ku lug leeyihiin gubida iyo burburka unugyada.
Mukhaadaraadka Biyoolojiyadu waa Kansaroolayaasha Kansarka
Daawooyinka bayoolojiga ah ayaa loo sameeyay si loo xakameeyo IL-1 ama TNF-alpha. Kineret (anakinra) waxaa loo sameeyay sidii daaweyn loogu talagalay rheumatoid arthritis-ka waxayna ka shaqeyneysaa joojinta qasnadda IL-1 ee la qabtey. TNF-alpha inhibitors (sidoo kale loo yaqaanno TNF-blockers ) waxay isku xidhan yihiin TNF waxayna ka hortagayaan TNF in ay ku xirmaan dib-u-qabayaasha dusha sare. Enbrel (etanercept), Remicade (Infliximab), Humira (Adalimumab), Simponi (golimumab), iyo Cimzia (certolizumab pegol) waa TNF-blockers. Actemra (tocilizumab) waxay xireysaa IL-6.
Daawooyinka bayoolojiga oo badanaa waa horumar. Natiijooyinka ka soo bartay cilmi-baarista Wajiga 3aad ee sarilumab (oo lagu magacaabo SARIL-RA-TARGET), oo ah difaac bani'aadam ah oo ka dhan ah daaweeynta IL-6, ayaa shaaca ka qaaday in daroogadu ay la kulantay labadeeda asaas ee horukaca calaamadaha iyo astaamaha rheumatoid arthritis iyo hagaajinta jirka shaqo.
Sarilumab waxay ku xidhan tahay ilmo aad u sarreeya oo loo yaqaan 'IL-6 reseptor', oo xannibaya joojinta IL-6 iyo carqaladeeya calaamadda cyokokine dhexdhexaadinta. Si kastaba ha noqotee, Oktoobar 31, 2016, FDA waxay diidday sarilumab iyada oo ku saleysan cilladaha ay heleen intii lagu jiray kormeerka geedi socodka wax soo saarka. Marka dib loo saxo, Regeneron iyo Sanofi waxay doonayaan in dib loogu soo celiyo ogolaansho sannadka 2017. Isla xilligaas, Febraayo 1, 2017, Health Canada waxay ogolaatay daawada hoos timaada magaca Kevzara (sarilumab).
Ereyga
Inkastoo cytokines u muuqdaan sida mawduuc adag, waa lagama maarmaan in la fahmo geedi socodka bararka ee ku jira qaybaha noocyada xanuunka arthritis-ka.
Waan ognahay in ay jiraan cyokokyo proinflammatory iyo cytokines anti-bararka. Cytokine proinflammatory cytokines door ka ciyaarida horumarinta xanuunka infakshan iyo neuropathic. Cytokines anti-bararka waa dhab ahaan cytokine cytokine inflammatory. Waxaa jira caddayn muujinaya in kiimikooyinka ay ku lug leeyihiin xanuunka, iyo sidoo kale ku adkaysashada xanuun.
> Ilo:
> Waxyaabaha Kobaca iyo Cytokines. > Astar > ku saabsan Cudurrada Rheumatic. Daabac 12. Waxaa daabacay Arthritis Foundation.
> Regeneron iyo Sanofi Natiijooyinka Heerka Sare ee Barashada Wajiga 3aad ee Sarilumab ee Kuleejka American College of Rheumatology. Regeneron. Nofeembar 8, 2015.
> McInnes I. iyo Schett G. Cytokines ee kudhaca cudurkan rheumatoid arthritis. Immunology Nature. Juun 2007
> Cytokines. BioBasics. 4/24/2006.
> Zhang, JM et al. Cytokines, Inflammation > iyo > Xanuun. Rugaha Caafimaadka ee Caalamiga ah. Bisha 2007.