Cudurka Tumor Necrosis wuxuu keenaa infakshan
Tumor necrosis factor (TNF) waa walax ay soo saaraan unugyada nidaamka difaaca jirka ee leh saameyno badan oo lagu hormarinayo hannaanka bararka . Waxaa aasaas u ah makrophages, nooca unugyada dhiigga cad, laakiin waxaa laga soo saari karaa unugyo kale sidoo kale.
Cudurka Tumor Necrosis ee Jawaabta Immune
TNF waa qeyb dabiici ah oo ka mid ah jawaabta jirka ee unugyada burooyinka, bakteeriyada, iyo fayraska.
Waxay ka ciyaareysaa qayb ka mid ah labada fal-celin-deg-deg ah iyo barar nidaamsan. Unugyada ayaa sii daaya markii ay ogaadaan walax gaar ah (Antigen) taas oo ay dareemeen dareemid.
TNF waa cytokin , oo ah borotiinka calaamadaha. Cytokines waa walxo kiimiko ah oo gudbiya farriimaha u dhexeeya unugyada jirka. Waxay qayb ka ciyaaraan hababka nafleyda badan, oo ay ka mid yihiin:
- Kordhinta unugyada
- Apoptosis, nidaamka caadiga ah ee dhimashada unug
- Cudurka dabaysha (dufanka)
- Coagulation, ama sameynta xinjiro dhiig
Cudurka Tumor Necrosis ee Cudurka
TNF waxaa laga yaabaa in lagu soo saaro xad-dhaaf ama aan haboonayn hababka kala duwan ee cudurada. Tani waxay dhalin kartaa caabuq joogto ah iyo calaamado kale oo burbur ah. Cuduradaan waxaa ka mid ah:
- Cudurada maskaxda sida xanuunka 'rheumatoid arthritis'
- Cadaadiska Insulin
- Kansarka
Cudurka Tumor Necrosis iyo Rheumatoid Arthritis
Tumor necrosis factor-alpha waa mid ka mid ah cyokokineska ugu muhiimsan ee ku lug leh rheumatoid arthritis iyada oo loo marayo isku-dhafid ku dhacda dareen-celinta inflammatory.
Caadi ahaan, jidhku wuxuu xannibayaa TNF dabiici ah. Laakiin cudurka rheumatic, wuxuu joogaa firfircoon wuxuuna abuuraa infakshan badan. Daawooyinka TNF-ka ayaa loo sameeyay si loo xakameeyo jawaab-celinta.
TNF Maandooriyayaasha
Dadka qaba xaaladaha caafimaad sida rheumatoid arthritis-ka , cudurka "psoriasis arthritis" , iyo cudurka Crohn-ka waxaa lagu daaweyn karaa daawooyinka TNF daawooyinka.
Daawooyinkani waxay ku xidhan yihiin qanjirada necrosis factor-alpha, waxay keeneysaa in aysan firfircooneyn. Tani waxay saameyn ku yeelaneysaa firfircoonida baraarujinta waxayna xakameysaa habka difaaca jirka. Dadka qaba rheumatoid arthritis-ka, tani waxay yarayn kartaa dhaawaca wadajirka ah. Daroogada ugu horreysa ee la ansixiyay 1998 ayaa la sameeyay. Waxay ku jiraan fasalka daawooyinka bayoolajiga , kuwaas oo ah daawooyin lagu beegsanayo molecules on unugyada difaaca jirka.
Daawooyinka ka hortagga TNF waxaa ka mid ah:
- Gundhig
- Qaadashada (Infliximab)
- Humira (adalimumab)
- Simponi (golbalab)
- Cimzia (certolizumab pegol)
Isticmaalida TNF Kaarayaasha
Xannibaadayaasha TNF looma qaadin hadal ahaan. Halkii, waa inaad ku duraysaa maqaarkaaga ama xididkaaga, badiyaa bowdada ama calooshaada. Marka la eego warbixinta bukaanka, isbeddellada ku dhaca calaamadahaaga waxay bilaabaan inay dhacaan kadib laba ama seddex qiyaasood.
Haddii dhakhtarkaagu kuu qoro TNF-ga la isku duro, waxaa laguu barayaa sida loo isku duro si aanad u tagin xafiiska dhakhtarka waqti kasta.
Haddii dhakhtarkaagu kuu sheego inflshabaab ama dhejis, waa inaad tagtaa xarunta faleebo ama xafiiska dhakhtarka illaa seddex saacadood si aad u hesho daaweyntaada. Daawooyinkaan ma aha kuwo la isku duro.
Saameynnada Calaamadaha Cudurka Tumor Necrosis
Xannibaadayaasha TNF waxay sababi karaan waxyeelo.
Sida caadiga ah waa fal-celinta goobta cirridka, taas oo badanaa ah firiiric ku-meel-gaadhsiis ah oo ay weheliyaan dareen gubasho ama cuncun.
Halista sii kordheysa ee dhammaan noocyada infakshanka waa waxyeellada ugu weyn ee ka iman karta xannibaadayaasha TNF sababtoo ah waxay xakameynayaan nidaamka difaaca jirka. U hubso in dhakhtarkaagu kuu baaro qaaxada iyo cagaarshow B inta aadan bilaabin daaweynta.
> Ilo:
> Macluumaadka ku saabsan Tumor Necrosis Factor (TNF) Blockers (Suuqa sida Remicade, Enbrel, Humira, Cimzia, iyo Simponi). Maamulka Cuntada iyo Dawooyinka Mareykanka.
> Tifaftireyaasha TNF. Kulliyadda Maraykanka ee Rheumatology.
> TNF Tumor Necrosis Faa'idada Dadka. Xarunta Qaranka ee Macluumaadka Biotechnology.