Daawo bayoolaji ah oo loogu talagalay rheumatoid arthritis
Adalimumab, oo inta badan loo yaqaan Humira, waa daroogada bayoolojiga ah ee ka shaqeeya joojinta borotiin la yiraahdo TNF-alpha . Caadi ahaan, TNF-alpha waxay ka caawisaa infakshanka dagaalka, laakiin qadarka xad-dhaafka ah, waxay keeni kartaa barar xanuun iyo waxyeelo ba'an oo wadajir ah (calaamadaha caadiga ah ee rheumatoid arthritis iyo noocyada kale ee xanuunka inflammatory arthritis ). Daroogada sida Humira waxay ka caawisay bukaanno badan oo qaba xanuunada rheumatoid-ka ee xannuunada, iyaga oo hagaajiya xanuunka, hagaajinta shaqada wadajirka ah, iyo in la yareeyo horumarka cudurka.
Guudmarka
Humira waa mid si buuxda loola beegsanayo monoclonal . Tani waxay ka dhigan tahay, in kasta oo lagu sameeyo nidaamyada bani-aadanka aadanaha, dhirta dhabta ah ee daroogada ayaa la mid ah tan unugyada difaaca jirka. Hase yeeshee, Humira oo ka soo jeeda qallalka TNF ee horay loo soo doortay ee horay loo ansixiyay - waxa uu ka kooban yahay borotiinka waxa laga soo qaatay qayb ka mid ah antibio non-human (mouse).
Sanadkii 2002, Humira waxaa markii hore ansixiyay Maamulka Cuntada iyo Dawooyinka ee Mareykanka (FDA) sidii daaweyn loogu talagalay rheumatoid arthritis. Waa mid ka mid ah daawooyinka nafleyda ee dhowr ah oo joojiya TNF-alpha, oo ay ka mid yihiin:
- Enbrel (Etanercept) : Daawada ugu horeysa ee TNF ee ay ansixisay FDA ee loogu talagalay rheumatoid arthritis-ka iyo noocyada kala duwan ee xanuunka 'arthritis' ee 1998.
- Qaadashada (Infliximab) : TNF-ta labaad ee ka hortagga TNF in ay ansixiso FDA 1999.
- Simponi (Gollulab) : Waxaa ogolaaday FDA 24-ka April, 2009.
- Cimzia (Certolizumab Pegol) : Waxaa ogolaaday FDA May 14, 2009.
Goynta
Humira waxaa lagu siiyaa subcutaneous (maqaarka hoostiisa) ee is-mudista labadii usbuucba mar. Bukaanka ayaa laga yaabaa in ay kugula taliyaan takhtarkooda in ay isbuuc kasta isku duraan haddii 14-kii maalmoodba uusan ku filneyn.
Waxaa markii hore la heli karaa isticmaalka kaliya, sirinjiraha horay loo buuxiyey. Isticmaal hal mar ah, nidaamka dhalida la marin karo ayaa sidoo kale la sameeyay, oo loo yaqaan 'Humira Pen'.
Si kastaba ha ahaatee, qiyaasta lagu taliyey, waa 40mg oo ah cirbadeynta isdaba-marinta iyadoo la isticmaalayo sirinjiraha horay loo buuxiyey ama Humira qalab kasta toddobaad kasta. Methotrexate , DMARD -yada kale ee aan biimooniga ahayn, glucocorticoids , daawooyinka nonsteroidal anti-inflammatory (NSAIDs) , ama xanuunada (daawooyinka xanuunka) ayaa la sii wadi karaa inta lagu daaweynayo Humira. Si kastaba ha ahaatee, waa in aan loo isticmaalin DMON-yada kale.
Calaamadaha
Tilmaamo badan ayaa lagu daray Humira tan iyo markii markii hore ay ansixisay FDA. Waxaa laga yaabaa in loo qoro si loo daaweeyo:
- Rheumatoid Arthritis
- Ankylosing Spondylitis
- Cudurka Psoriatic Arthritis
- Cudurka 'Idiopathic Arthritis'
- Plaque Psoriasis
- Colitis Cagaarshow
- Cudurka Crohn ee Dadka Waaweyn iyo Cudurada
- Hidradenitis Suppurativa
Waxyaabaha kale ee saameynaya
Waxyeellooyinka caamka ah ee la xiriira Humira waxaa ka mid ah:
- Dareen-celin goobta bogsashada fudud
- Finan
- Madax xanuun
- Calool xanuunka ama lallabbo
- Pneumonia
Diidmada xun
Sababtoo ah waxay xakameyneysaa jawaab celinta difaaca jidhka kaas oo sida caadiga ah la dagaallama caabuqa, Humira waxa uu la xiriiray cudurro halis ah, sida qaaxada, sepsis, iyo fungal infekshinka. Waxay sidoo kale ka sii dari kartaa calaamadaha cudurrada nidaamka dareenka (tusaale ahaan, cudurada neefsashada). Xanuunnada bukaan socodka, bukaanjiifka qaar ayaa lahaa heerar sare oo kansar iyo lymfoma muddo 24 bilood ah.
Yaa qasban yahey in aysan qaadan Humira
Humira waa in aan loo isticmaalin bukaannada xasaasiyad leh oo loo yaqaanno daroogada ama qaybaheeda. Sidoo kale ma isticmaali karaan bukaanada uur leh ama kalkaalisada.
Daawada waa in aan loo qorin bukaanka qaba infakshan firfircoon ama bukaanno loo arko in ay qaadaan infekshin, oo ay ku jiraan bukaanka qaba sonkorowga aan kontoroolka lahayn ama bukaanka qaba taariikhda cudurro soo noqnoqda.
U sheeg dhakhtarkaaga
- Haddii aad qabto infakshan firfircoon
- Haddii aad qaadday Cagaarshow B ama aad tahay sidee (Humira ayaa la xiriirta dib u soo noqoshada cagaarshowga B)
- Haddii aad qabto kabuubyo, xannuun, ama calaamado badan oo maskaxda ah ama nidaam dhexdhexaad ah oo habdhiska dareenka ah
- Haddii lagaa daaweeyey wadnaha oo aan shaqeynin
- Ka hor intaadan helin wax tallaal ama qalliin
Si aad u soo sheegtid fal-celin xumo, waxaad la xiriiri kartaa AbbVie Inc. 1-800-633-9110 ama FDA oo ah 1-800-FDA-1088 ama www.fda.gov/medwatch.
Ilaha:
Zashin, MD, Scott J .. Arthritis oo aan Xanuun lahayn. Sarah Allison Publishing Company.
Humira . Shaybaarada Abbott. Macluumaadka Qorista. 2016.