Cimzia waa boogaha TNF loo isticmaalo xinjirowga bararka
Cimzia (certolizumab pegol) waa TNF (tumor necrosis factor) xayiraad - isku mid ah daroogada sida Enbrel (etanercept) , Remicade (Infliximab) , Humira (adalimumab) , iyo Simponi (golimumab). Cimzia waa daroogada kaliya ee fasalka TNF oo keena in uu sunta ku yaraado unugyada sababtoo ah sifooyinka kimikalka (tusaale ahaan, PEGylated, gobolka Fc free). Intaa waxaa dheer, marka la barbardhigo kuwa kale ee TNF-ta ah, Cimzia ayaa la sheegay inay leedahay jacayl ka sarreeya TNF.
Waa maxay TNF?
Waxay ka caawisaa inay ogaadaan waxa TNF yahay si aad si fiican u fahmi karto sababta Cimzia u shaqeyneyso si loo xakameeyo. TNF waa cytokin , asal ahaan waa farriin udub dhexaad u dhexeeya unugyada, kuwaas oo door ka ciyaara geedi socodka nabarrada . Wax-soosaarka TNF-alpha-ka ee jirka ayaa waxaa lala xiriiriyay cuduro iyo xaalado dhowr ah, oo ay ku jiraan rheumatoid arthritis .
Sidee Cimzia loo siiyaa?
Cimzia waxaa lagu duraa maqaarka hoostiisa. Waxaa loo soo qaataa budo ah in loo baahan yahay in la naqshadeeyo habka dareeraha si loo siiyo cirbadaynta subcutaneous.
Hantidhowrka, UCB, Inc., wuxuu sheegay in alaabada kiimikada ee Cimzia ay ka dhigi karto ikhtiyaar ka wanaagsan taakulada TNF ee loogu talagalay dadka qaba cudurka rheumatoid arthritis. Qalabkaas wuxuu yareyn karaa dareen-celinta dhibaatada ee la isku duro iyo daawooyinka mukhadaraadka si loo helo goobo bararro ah, ayaa laga yaabaa in la hagaajiyo, oo u baahan qiyaasta daaweyn inta badan ka badan kuwa kale.
Ka dib qiyaasta bilowga ah, waxaa jira jadwal qiyaas ah oo jajaban.
Cimzia waxaa la siin karaa laba ama afar toddobaad - mid kali ah ama leh daawada methotrexate.
Cimzia Waxqabadka Xanuunada Daaweynta
Natiijooyin tijaabo ah oo tijaabo ah ayaa laga soo sheegay Cimzia. Laba barood oo maaddo III ayaa muujiyay faa'iido weyn marka Cimzia loo isticmaalo kaligiis ama si wadajir ah loogu isticmaalo daawada methotrexate ee dadka qaangaarka leh rheumatoid arthritis firfircoon (ie, synovitis firfircoon ).
Gaar ahaan, 24-ka toddobaad ee Daraasada FAST4WARD waxay muujisay in 400 mg Cimzia, oo la siiyay 4-kii toddobaadba, oo si weyn loo yareeyey xanuunka iyo calaamadaha cudurka rheumatoid arthritis iyo ficil ahaan jireed oo kordhay marka la barbar dhigo kuwa ku jira xuubka.
Daraasadihii RAPID wuxuu shaaca ka qaaday faa'iidada isticmaalka Cimzia iyo daawada methotrexate. RAPID1 waxay muujisay faa'iido mudo dheer ah isticmaalka Cimzia marka la eego calaamadaha gargaarka, hagaajinta wax soosaarka iyo tayada nolosha, iyo daalinta daalinta. Daraasad labaad oo ah RAPID, oo loo yaqaano RAPID2, ayaa muujisay in Cimzia iyo daawada methotrexate ay si weyn u hagaajisay calaamadaha iyo astaamaha rheumatoid arthritis-ka, kor u qaadida horumarka cudurkan, iyo hawlaha jireed ee hagaajinta jirka ee bukaanka qaba rheumatoid arthritis-firfircoon.
Saameynta Cimzia
Saameyno daran oo ka yimaada dadka qaar ayaa qaadatay Cimzia. Macluumaadka qoritaanka ee la heli karo ee Cimzia wuxuu ka digayaa:
- Caabuqyo halis ah, oo ay ku jiraan qaaxada
- Kansarka, oo ay ku jiraan lymphoma
- Dhibaatooyinka habdhiska neerfaha , oo ay ku jiraan sclerosis multiple
- Dareen-celinta xasaasiyadda
- Dhibaatooyinka dhiigga
- Wadnaha cusub ee cusub ama sii xumaanaya wadnaha
- Dareen-celinta calaamadaha, oo ay ka mid yihiin lupus-like syndrome
Ciladaha ugu caansan ee la xiriira Cimzia waa infakshannada neefta sare, infakshanka kaadimareenka, xanuunka wadajirka, iyo fal-celinta goobta la isku duro.
Ma yahay Cimzia FDA-la ansixiyey?
Abriil 22, 2008, Cimzia wuxuu ahaa FDA-ansixiyay inuu daaweeyo cudurka Crohn ee dhexdhexaad ah ama mid aad u firfircoon ee dadka qaangaarka ah ee aan lagu caawinin daaweynta caadiga ah. Maajo 14, 2009, Cimzia waxaa ogolaaday FDA si loo daaweeyo bukaanno qaangaar ah kuwaas oo qaba xanuunka 'rheumatoid arthritis-ka' si firfircoon oo firfircoon. Tilmaamaha ayaa sidoo kale lagu daray cudurka psoriasis ee arthritis iyo ankylosing spondylitis .
Cimzia waxaa laga heli karaa siriinjo horay loo buuxiyey kaas oo qabanaya Arthritis Foundation ee Isticmaalka Isticmaalka Isticmaalka Arthritis. Naqshadeynta sirinjiga ayaa ah natiijada ka dhaxaysa UCB iyo OXO (waxaa ugu wanaagsan ee loo yaqaan khariidada wax lagu kariyo ee jimicsiga iyo qalabka kale ee isticmaala).
Ilaha:
Cimzia. Macluumaadka Dajinta Qorista. UCB. Dib loo saxay April 2016.
http://www.cimzia.com/assets/pdf/Prescribing_Information.pdf
Cimzia. Tilmaamaha Dawooyinka. UCB, Inc. Revised April 2016.
http://www.cimzia.com/assets/pdf/MedicationGuide.pdf