Tikidhkii ugu horreeyay ee TNF ee la ogolaaday ee loo yaqaan 'Rheumatoid Arthritis' 1998
Enbrel (etanercept) waa habdhaqameeyaha jawaab-celiyaha noolaha (oo ah dib-u-naqshadeenta necrosis ee necrosis factor protein-ka soo-saarka fiyuuska). Enbrel waxaa la isku dayey in uu noqdo sida kuwa soo dhaweeyaha ee jirka ku xiran naaquska necrosis (TNF-alpha). Enbrel wuxuu u shaqeeyaa isagoo qulqulaya TNF xad-dhaaf ah ka hor inta aaney ku xirneyn xayawaanka dabiiciga ah.
TNF-alpha waa cytokin ku lug leh geedi socodka nabarrada.
TNF-alpha oo dheeraad ah ayaa lala xiriiriyay rheumatoid arthritis-ka iyo noocyada kale ee xanuunka infekshanka .
Mukhaadaradaha la midka ah
Enbrel wuxuu ahaa daawada ugu horreysa ee TNF waxaana la ansixiyay sannadkii 1998-kii si loogu daaweeyo rheumatoid arthritis-ka iyo noocyada kala duwan ee xanuunka arthritis-ka. Remicade (infliximab) wuxuu ahaa tii labaad ee TNF-ka hortaagan oo ay ansaxiso Maamulka Cuntada iyo Dawooyinka ee Maraykanka 1999. Humira (Adalimumab) ayaa la ansixiyay 2002. Simponi (golimumab) waxaa ansixiyay FDA 24-ka Abriil, 2009. Cimzia (certolizumab pegol ) wuxuu ahaa FDA oo la ansaxiyay May 14, 2009.
Enbrel waxaa laga soo saaraa iyada oo loo soo bandhigo DNA-ga dadka ee loo yaqaano "hamster-ka" ugxansiisan uguna abuuraya borotiinka taranka. Qaadashada waxay isticmaashaa borotiinka bini'aadamka iyo mashiinka si loo abuuro antibio monoklonal monoklonal . Humira waxay isticmaashaa borotiinka bini-aadanka si buuxda iyo farsamada bandhig farsamo si loo soo saaro unugyada difaaca monoclonal.
Maamulka
Enbrel waxaa loo maamulaa cirbadeynta subcutanous mar ama laba jeer todobaadkiiba (3 ama 4 maalmood oo is barbar dhigo).
Qiyaasta daawada loo qoray waxay kuxirantahay xaalada daaweynta. Faafinta waa in uu kuu qoro takhtarkaaga wuxuuna u baahan yahay oggolaansho kahor caymiska. Dheecaan ayaa loo isticmaali karaa methotrexate oo loogu talagalay bukaanada aan ka jawaab celin methotrexate oo keliya.
Daawo qorista
Enbrel ayaa loo ogolaaday in lagu daaweeyo arthritis-ka dhexdhexaad ah iyo mid daran, xanuun dhexdhexaad ah oo daran oo loo yaqaan ' rheumatoid arthritis' , ' psoriatic arthritis' , ' spolitylitis anchylosing spondylitis ' , ' psoriasis' dhexdhexaad ah oo daran.
Miisaanka lagu taliyey
Dadka qaangaarka ah ee qaba rheumatoid arthritis-ka, cudurka psoriasis arthritis-ka, iyo daawada isdilosing spondylitis, qiyaasta caadiga ah ee Enbrel waa 50 mg toddobaadkii oo lagu qaato cirbadaynta subcutaneous iyadoo la isticmaalayo 50 mg / ml sirinjir la isticmaalo. Waxaa jira 25 mg oo ah qasacado Enbrel oo sidoo kale la heli karo.
Qiyaasta loo yaqaan 'Enbrel' ee loo yaqaan 'rheumatoid arthritis-ka' ayaa ku salaysan miisaanka ilmaha. Doorasho qiyaasta hal toddobaad ah ayaa jira oo loogu talagalay carruurta ku dhagan 138 rodol ama ka badan. Cudurka psoriasis-da , qiyaasta caadiga ah waa 50 mg laba jeer toddobaadkii muddo 3 bilood ah, oo ay hoos u dhacaan hal mar toddobaadkii.
Walaacyo gaar ah
Enbrel laguma talineynin dumarka uurka leh ama kuwa kalkaaliyaha ah. Bukaanka qaba cudurada halista ah waa in aan lagu daaweynin Enbrel. Dadku waxay u nugul yahiin infekshin ama kuwa qaba sokorowga aan kontoroolin waa inaysan isticmaalin Enbrel. Bukaanka qaba xaalado gaar ah ee nidaamka dhexe ee dareenka waa in laga fogaadaa Enbrel.
Saameynada Caadiga ah
Waxyeellooyinka caamka ah ee la xidhiidha Enbrel waxaa ka mid ah:
- dareen-celinta goobta
- infakshannada neefta sare, oo ay ku jiraan infekshannada sanbabada
- madax xanuun
- dawakhaad
- sanka oo dareema
- dhuun xanuunka
Dulleenta xun ee xun
Faafinta ayaa kordhin karta khatarta cudurada halista ah. Dadka lagu daaweeyo Enbrel, waxaa jira warbixino badan oo ah nabaro badan , mellitamiin (bararka xiidmaha), faafida indhaha (optic neuritis), iyo pancytopenia (tiro yar oo unugyada casaanka ah, unugyada cad, tarada).
Kaydinta
Dareemku waa in lagu keydiyaa heerkul ah 36 illaa 46 darajo Fahrenheit. Si kastaba ha ahaatee, Enbrel waxaa lagu hayn karaa heerkulka qolka illaa 14 maalmood. Dareemku marnaba laguma kaydin barafeeyaha.
Sida laga soo xigtey enbrel.com, haddii aad u safreyso wax ka badan saacado yar, waa inaad ku duubtaa Enbrel xayeysiisyada xumbada oo ku rid barafeeyaha socdaalka leh barafka. Isticmaal heerkulbeega si aad u qaboojiso oo u hubi saacado kasta. Waxaad heli kartaa qaboojiye bilaash ah iyo xirmo baraf ah ee Enbrel adigoo wacaya Taageerada Enbrel ee 1-888-4ENBREL. Haddii aad ku safreyso hawo, ka hubi shirkadda diyaaradaha shuruudaha.
Ilaha:
Arthritis Without A Pain, Scott J. Zashin, MD, waxaa daabacay Sarah Allison Publishing Company.
Enbrel - Buugga Kiniisiga, 10aad
Tilmaamaha Dawooyinka. Enbrel.com. Dib loo eegay 11/2013. http://pi.amgen.com/united_states/enbrel/derm/enbrel_mg.pdf
Macluumaadka Qorista. Enbrel.com. Dib loo eegay 03/2015. http://pi.amgen.com/united_states/enbrel/derm/enbrel_pi.pdf