Dhammaadkii 1990-maadkii, daroogada ugu horeysa ee bayoolojiga ah ayaa suuqa ka soo baxday si loo daweeyo xannuunka rheumatoidimada . Enbrel (etanercept) wuxuu ahaa kii ugu horreeyay, laakiin ma aysan qaadin muddo dheer daawooyinka kale ee bayoolojiga ah si loo horumariyo laguna iibiyo.
Sida laga soo xigtay UpToDate ( tixraac elektaroonik ah oo lagu kalsoon yahay oo loo adeegsado dhakhaatiir badan iyo bukaanno raadinaya macluumaad qoto dheer oo si faahfaahsan loo sharaxay):
"Beddelaha waxqabadka nafleyda, oo loo yaqaan biologics, ayaa ah daawooyin loo qorsheeyay inay ka hortagaan ama yareeyaan bararka waxyeelada u geysta xubnaha taranka Biologiska bartilmaameedka molecules ee unugyada difaaca jirka, wadajirka, iyo alaabooyinka lagu qarsado wadajirka, dhammaantood waxay u keeni kartaa gubasho iyo burbur wadajir ah. Waxaa jira noocyo kala duwan oo bayooloji ah, mid kasta oo ka mid ah bartilmaameed nooc gaar ah ee maadi ah ee ku lug leh geedi socodkan (burka (necrosis factor), interleukin-1, iyo molecules dusha sare ee unugyada T iyo B lymphocytes). "
Mukhaadaraadka Biyoolojiga iyo Bartilmaameedkooda
- Humphrey ( etliercept ), Remicade ( Infliximab ), Humira (adalimumab), Simponi (golligab), iyo Cimzia (certolizumab pegol) waa daroogo nooloole oo bartilmaameed u ah qanjirka 'tumor necrosis' (TNF). Waxaa badanaa loo yaqaannaa TNF-blockers iyo, sida caadiga ah, mid ka mid ah TNF-ta xirayaasha ayaa ah daroogada ugu horreysa ee lagu baaro.
- Kineret (anakinra) wuxuu joojiyaa interleukin-1. Waxaa guud ahaan loo tixgeliyaa sida nafleyda yaryar oo ka yar tan ka horjeeda TNF iyo inta badan lama qorin.
- Orencia (abatacept) ayaa joojisa waxqabadka unugyada T. Badanaa, Orencia waxaa loogu talagalay bukaanka qaba arthritis-ka dhexdhexaad ah ama daran ee aan awoodin inay maamulaan cudurkooda methotrexate iyo TNF blocker.
- Rituxan (rituximab) ayaa ka dhigta unugyada B. Mar labaad, daroogadaan waxaa caadi ahaan loogu talagalay bukaanada leh natiijo aan fiicneyn oo leh daawada methotrexate iyo TNF blocker.
- Actemra (tocilizumab) wuxuu u shaqeeyaa iyadoo la xakameynayo daawada interleukin-6, taas oo xannibaysa interleukin-6.
Yaa Lagu Xakameyn Karaa Biology?
Bukaan-jiifka ku dhacay jawaab-celin aan ku qancin DMARD (cudur-is-beddelidda dawooyinka antiromumatic), mid kali ahaan ah ama mid la mid ah daawooyinka kale ee arthritis-ka, ayaa badanaa ah musharaxiin wanaagsan oo loogu talagalay bayoolojiga. Marka loo barbardhigo DMARDs, bayoolojiga ayaa si dhakhso ah u shaqeeya. Waa inaad ogaataa haddii aad ka jawaabayso toddobaadyo gudahood marka aad bilaabayso daroogada bayoolojiga ah.
Yaa Yaa Lagu Xakameyn Karaa Biology?
Nasiib darro, waxaa jira bukaanno aan u qalmin inay daaweeyaan daawooyinka bayolojiga. Waxaa jira shuruudo gaar ah oo khatarta ay u badan tahay inay ka badan tahay faa'iidooyinka daaweynta daawooyinka bayoolojiga ah.
Tusaale ahaan, bukaanka qaba taariikhda hore ee cudurka sclerosis ama lymphoma ma noqon karto musharaxiin wanaagsan. Bukaan-socodka qaba cillad wadnaha oo aan cillad lahayn ayaa sidoo kale ah musharaxiin wanaagsan. Sidoo kale waa mid khatar ah in la isticmaalo mukhaadaraadka bayoolojiga ah marka bukaanku leeyahay taariikhda cudurro daran ama soo noqnoqda.
Waa kuwee Biologics Haddii aad Isticmaalaysid?
Dhakhtarkaagu wuxuu kaa caawin doonaa inaad doorato nafleyda ugu fiican. Kharashka dhab ahaantii waa tixgelin. Adiga iyo dhakhtarkaagu waa inay go'aamiyaan haddii caymiskaaga caafimaad uu dabooli doono daroogada aad doorato-ama waxa kharashka kaaga baxsani noqon doono.
U hubso in ay kugu haboon tahay.
Tixgelin kale waa feejignaan. Sidee baa daroogada loo maamulaa? Ma inaad u tagtaa xafiiska takhtarka si loo daaweeyo ama ma kugu fiicnaan lahayd inaad doorato mid ka mid ah daroogooyinka bayoolojiga ah ee loo maamulo sida isqorista? Intee jeer ayaa daroogada la maamulaa-mar toddobaadkii, laba jeer toddobaadkii, laba toddobaad kasta, ama bil kasta? Maxay tahay doorashadaada?
Sidoo kale, muxuu muhiim u yahay inaad doorato dawo leh rikoodh wanaagsan, si kale haddii loo dhigo, mid ka mid ah kuwa duqoobay, halkii laga noqon lahaa mid cusub, bayooloji? Kuwani waa wax walba oo ay tahay in la tixgeliyo maxaa yeelay haddii aad dooratid waxa adiga kugu haboon, waxaa laga yaabaa in aad u sii dheeraato adigoo raacaya daaweyntaada.
Xigasho:
Maini RN iyo Venles PJW. "Macluumaadka Bukaanka: Daaweynta Rheumatoid Arthritis" UpToDate.