Waa maxay Cilmi baadhista
Amitriptyline waa antidepressant caan ah kaas oo la heli karo oo kaliya foomka guud ee Maraykanka Waxaa loo isticmaalay in lagu iibiyo hoos magaca magaca calaamad Elavil.
Amitriptyline waxaa lagu qeexay sida tricyclic antidepressant. Muddo sanado ah, dhakhaatiirta qaarkood waxay u tixgeliyeen daaweynta hore ee loogu talagalay fibromyalgia iyo dareenka dareenka daba-dheer ( ME / CFS ). Hase yeeshee, arrintani waxay ka badan tahay isticmaalka tijaabo-iyo-khalad ka badan daraasadaha kiliinikada.
Sanadihii la soo dhaafay, gaar ahaan soo ifbaxa daaweynta FDA-da ee daaweynta fibromyalgia, isticmaalka amitriptyline ee cudurkan ayaa hoos u dhacay. Si kastaba ha ahaatee, Amitriptyline weli wali, waxay mararka qaar isticmaashaa daroogo tixraac ah oo ku saabsan daaweynta fibromyalgia, iyo dhakhaatiir badan oo wali ku qora xaaladahaas.
Sida ay u shaqeyneyso
Amitriptyline iyo daawooyinka tricyclic ee kale ayaa loo maleynayaa inay kordhinayaan qiyaasta serotonin neurotransmitters iyo norepinephrine in maskaxdaadu ay isticmaali karto. Waxay sidan ku sameeyaan iyagoo hoos u dhigaya habka loo yaqaan "reuptake", taas oo ah marka unugyada khaaska ah ay u neefsadaan nurotransmitters si ay dib ugu isticmaalaan meelo kale.
Daawooyinka kale ee niyadjabka, oo lagu magacaabo celiyeyaasha dib-u-qabashada, waxay isticmaalaan habab kala duwan si loo gaadho saameyn la mid ah.
Serotonin iyo norepinephrine ayaa la rumeeysan yahay in lagu kala saaro fibromyalgia iyo ME / CFS labadaba.
Sidoo kale fiiri:
- Fahmitaanka Dib-u-Celinta
- Serotonin ee Fibromyalgia & ME / CFS
- Norepinephrine ee Fibromyalgia & ME / CFS
Fibromyalgia
Dib u eegista 2012 ee amitriptyline ee fibromyalgia ayaa tan ku sheegtay in isticmaalka daroogada ee fibromyalgia:
Amitriptyline wuxuu ahaa daaweyn koowaad ah oo loogu talagalay xanuunka neuropathiska sanado badan. Xaqiiqada ah in aysan jirin wax caddayn ah oo taageeraya nacfiga waxtar u leh faa'iidada faa'iidada leh waa niyadjab, laakiin waa in lagu xisaabtamo mudo tobanaan sano ah oo daaweyn lagu guulaystay bukaanno badan oo qaba xanuunka neuropathic ama fibromyalgia. (Moore, et al, hoosta.)
Dib-u-eegisku wuxuu ku saabsanyahay in wax laga badiyo waxtarkeeda ay tahay walaac sababtoo ah daraasadihii dhowaa waxay muujinayaan oo kaliya dad tiro yar oo dad ah oo isku dayaya in ay u qalmaan gargaarka xanuunka.
Dib u eegid kale oo sannadkaas ah, oo sidoo kale ay ku jirto daawada antidepressants duloxetine iyo milnacipran, ayaa sheegay:
Tiro yar oo bukaanjiif ah ayaa la kulma cilad fara badan oo aan wax saameyn ah lahayn ama waxyeello xun. Si kastaba ha noqotee, tiro badan oo bukaanjiif ah ayaa hoos u dhac ku yimaada daaweynta sababtoo ah saameyn aan caqli-gal ahayn oo aan la daweyn karin ama la kulmo kaliya ciladaha yar-yar ee calaamadaha, taas oo aan ka badneyn waxyeellooyinka xun. (Hauser, Wolfe et al, hoosta.)
Dib-u-eegis 2011 (Clemons, et al, hoos) wuxuu soo gabagabeeyay in amitriptyline aan loo tixgelin karin sida dahabka-heerarka fibromyalgia sababtoo ah xanibaadaha daraasadihii la qabtay.
Si kastaba ha ahaatee, sidoo kale, 2011, dib u eegis ku saabsan fasallada daroogada ee fibromyalgia (Smith, et al, hoosta) ayaa sheegay in amitriptyline uu la mid yahay daawooyinka FDA-la ogolaaday - Lyrica (pregabalin), Cymbalta (duloxetine), iyo Savella (milnacipran) marka wuxuu u yimid xanuun iyo daal.
Dhakhaatiirta qaarkood waxay doorbidaan amitriptyline dhowr sababood:
- Taariikhda dheer ee isticmaalka, iyo
- Qiimaha hooseeya marka la barbar dhigo daawooyinka FDA-da ee daawada fibromyalgia.
Tusaale ahaan, hal bil gudaheed oo ah qalab amitriptyline ah ayaa ku kici kara inta u dhexeysa $ 15 iyo $ 65, taasoo ku xiran qiyaasta. Dhanka kale, hal bil oo ah qalabka Cymbalta (duloxetine), Lyrica (pregabalin), ama Savella (milnacipran) waxay ku bilaabataa qiyaastii $ 125 waxayna u dhexeysaa ilaa $ 180. (Tani waxay isbeddeli kartaa sida duloxetine guud oo ka imanaysa suuqa.)
Xanuunka Xanuunka Xanuunada Dabiiciga ah
Amitriptyline wuxuu leeyahay taariikh dheer oo la adeegsanayo ME / CFS, mar kasta inkastoo maqnaanshaha daraasaddaha caafimaad iyo sababtoo ah kormeerka dhabta ah ee horumarinta. Daraasad aad u yar ayaa la sameeyey.
Daraasada 2012, si kastaba ha ahaatee, waxay eegtay amitriptyline ee ME / CFS oo waxay ogaatay inay tahay midka kaliya ee ka mid ah dhawrka daawooyinka antidepressant-ka ee la tijaabiyay in la sii daayo cytokines -ka lakulmay cyokokine , kuwaas oo la aaminsan yahay inay kaalin ka qaataan ME / CFS.
Qiyaasta
Dadka qaangaarka ah, qiyaasta amitriptyline ee caadiga ah waxay u dhexeysaa 40 mg ilaa 150 mg maalintii. Badanaa waxaa loo qaybiyaa qiyaaso badan.
Waxay qaadan kartaa illaa bil gudaheed si aad u aragto isbeddel sababtoo ah daawadan.
U hubso inaad raacdo tilmaamaha dhakhtarkaaga ee ku saabsan qaadashada daawadan. Haddii aad rabto inaad joojiso qaadashada, ha joojin si deg-deg ah. Weydiiso dhakhtarkaaga habka ugu haboon ee looga saaro daroogada.
Waxyaabaha kale ee saameynaya
Sida dhammaan antidepressants, waxay digniin ka bixineysaa khatarta sii kordheysa ee fekerada isdilka ama isku dayida dadka da'doodu ka yar tahay 24 sano.
Amitriptyline wuxuu leeyahay liis dheer oo ah saameynaha suurtagalka ah. Saameynaha caadiga ah waxaa ka mid ah:
- Xasiloonida,
- Kabaha,
- Lalabbo ama matag,
- Dhibaato kaadida,
- Caloosha,
- Dhirashada xad-dhaafka ah,
- Isbedelka miisaanka ama cuntada,
- Isbedelada kudhaca jinsiga ama awoodda galmada,
- Xanuun, gubasho ama xoqan gacmaha ama lugaha.
Haddii aad leedahay mid ka mid ah dhibaatooyinka soo socda ee daran, waa inaad isla markiiba wacdaa dhakhtarkaaga:
- Hadalka qallafsan, hadalka adag,
- Suuxdin,
- Tabar daro ama kabuubis xoqan,
- Xanuun xanuun laabta,
- Qalbigal aan joogto ahayn,
- Finan daran ama finan,
- Barar wejiga iyo afka,
- Maqaarka ama indhahaaga huruudka ah,
- Murqaha muruqyada ee daanka, qoorta iyo dhabarka,
- Ruxin aan la kontorooli karin,
- Dhiig-bax aan caadi ahayn ama nabar,
- Qalabka,
- Maqalka.
Sababtoo ah daawadani waxay kordhinaysaa xaddi badan oo serotonin ah, waa inaad iska ilaalisaa daawooyinka kale ee kordhiya serotonin oo baro calaamadaha fal-celinta suuragalka ah ee dili kara: Serotonin Syndrome.
Sida daroogo kasta, waxaa muhiim u ah adiga iyo takhtarkaaga in ay miisaanka ku jiraan khatarta ka imaan karta faa'iidooyinka iyo go'aan ka gaadha daaweynta kugu haboon.
Ilaha:
Clemons A, et al. Joornaalka cilmi nafsiga ee cilmi nafsiga. 2011 Jun; 31 (3): 385-7. Amitriptyline iyo prochlorperazine naabiyadeeriya dhexdhexaadiye nacaybka oo ka sii daaya unugyada sifooyinka bini'aadamka: suurta galnimada suurtagalnimada cilladda dareenka daba dheeraatay.
Hauser W, Petzke F, iyo al. Rheumatology (Oxford.) 2011 Mar; 50 (3): 532-43. Waxtarka u dhigma iyo aqbalida amitriptyline, duloxetine iyo milnacipran ee fibromyalgia syndrome: dib u eegis nidaamsan oo lagu sameeyo falanqaynta maadada.
Hauser w, Wolfe F, iyo al. Dawooyinka CNS. 2012 Apr 1; 26 (4): 297-307. Doorka daawooyinka antidepressant ee maamulka ee fibromyalgia syndrome: dib-u-eegis nidaamsan iyo falanqayn-baaritaan.
Moore RA, et al. Macluumaadka Cochrane ee dib u eegista nidaamka. 2012 Dec 12; CD008242. Amitriptyline xanuunka neuropathic iyo fibromyalgia ee dadka waaweyn.
Okea, R. Dhakhtar qoys Maraykan ah. 2010 Oct 15; 82 (8): 901-904. Milnacipran (Savella) loogu talagalay fibromyalgia.
Smith B, iyo al. Baadhitaanada Daroogada. 2011 Apr. Dib u Eegista Noocyada Daroogada: Daroogooyinka Fibromyalgia: Warbixinta Ugu Danbeysa.
Maamulka Cuntada & Dawooyinka Mareykanka Wargalinta Amirrada Amitriptyline. Laga soo bilaabo September 2014.