Sidee cuntada dheeraadka ah ee berberine ay u bixiso rajo haweenka ay hayso PCOS.
Berberine waa kaalmadii qadiimiga ah ee lagu isticmaalo China muddo kumanaan sano ah sida daaweynta cudurka macaanka, shubanka, iyo dhalmo la'aanta. Hadda cilmi baaris ayaa bilawday in ay baaritaan ku samayso isticmaalkeeda haweenka qaba cudurka kansarka ugxanta ah ( PCOS ) illaa iyo hadda, natiijooyinka ayaa aad u dhiirigalinaya.
Maxay tahay Berberine?
Berberine waa alkaloid laga soocay geedo Shiine ah sida dahabshad jilicis ah (dahab ah), Berberis aquifolium (canab), berberis vulgaris (barberry), berberis aristata (rootedis geed), iyo nadiifinta nacasta (huanglian).
Waxaa loo qaadan karaa kaabsoom ama qaabab dareere ah.
Qaadashada berberine ayaa la muujiyey si ay u caawiso hagaajinta xaalado badan oo kala duwan, oo leh faa'iidooyin sida kuwa soo socda:
- Waxay hagaajisaa caabbinta insulin
- Waxay mamnuucaysaa testosterone
- Yaree finanka
- Wuxuu lumiyaa heerarka kolestaroolka
- Waxay hagaajisaa cudurka beerka dufanka aan khamriga lahayn
- Waxay hagaajisaa uurka iyo bacriminta
- Waxay bixisaa taageerada Immune
- Waxay bixisaa faa'iidooyinka anti-microbial
- Waxay hoos u dhigtaa cadaadiska dhiigga
- Qalabka luminta miisaanka iyo luminta jidhka
- Daaweynta ka hortagga kansarka
Berberine iyo PCOS
Berberine waxay bixin kartaa faa'iidooyin badan haweenka PCOS oo ay ka mid yihiin horumarinta bacriminta, ka caawinta miisaan lumis, iyo hoos u dhigida khatarta dhibaatooyinka dheef-shiid kiimikaadka ee la xiriira cilladda cudurka sida sonkorowga nooca 2, kolestaroolka sare, iyo cudurada beerka dufanka leh.
Naas-nuujiye Insulin ah
Waxaa laga yaabaa in kaalinta ugu weyn ee berberine ay tahay mid dareen xoog leh oo insulin ah. Haweenka qaba PCOS ayaa lagu muujiyay inay leeyihiin heerar sarreeya oo insulin marka la barbardhigo dumarka miisaan isku mid ah oo aan lahayn xaalad.
Metformin waa daawo insulin-dareen-siin ah oo inta badan loo qoro haweenka PCOS si ay u caawiyaan maareynta insulin iyo heerarka gulukoosta. Hase yeeshee, haween badan oo leh PCOS waxay dareemaan saameynaha caloosha iyo mindhicirka ee metformin sida shuban, lallabo, iyo calool xanuun. Isticmaalka metformin muddada dheer ayaa sidoo kale lagu muujiyey inay saameynayso nuugista vitamin B12 .
Berberine ayaa lagu muujiyay in uu hagaajiyo caabbinta insulinta si la mid ah sida metformin. Berberine wuxuu hagaajiyaa isbeddelka calaamadaha insulin by kicinta guluukoosta iyada oo loo marayo dhiirigelinta wadada kinase proteinineed AMP.
Faa'iidooyinka berberine ayaa la barbardhigay metformin haweenka qaba PCOS. Daraasad lagu daabacay Jariidadda Yurub ee Endocrinology , Wei iyo asxaabtu waxay si aan kala sooc lahayn u dooran 89 haween ah oo leh PCOS si ay u qaataan berberine (500 mg, saddex jeer maalintii), metformin (500 mg, saddex jeer maalintii), ama booska 3 bilood.
Dhamaan dumarka waxaa lagu baray nafaqeyn si loo yareeyo qaadashada karbohidraatka iyo dufanka. Qalabka kalooriga lama bixin. Dumarka waxaa sidoo kale lagu faray in ay jimicsi sameeyaan 30 daqiiqo maalin kasta oo leh jimicsi dhexdhexaad ah ilaa jimicsi xoog leh
Kadib 3 bilood oo daaweyn ah, haweenka qaba PCOS ee qaata berberine waxay arkeen yareyntooda yareynta dufanka jirka marka loo eego metformin ama placebo. Berberine wuxuu hoos u dhigay insulin iyo heerarka gulukoosta sida metformin.
Haweenka haysta PCOS ee qaata berberine waxay hoos u dhigeen hoos u dhaca guud ahaan kolestaroolka , LDL (heerarka kolesteroolka xun), iyo triglycerides iyo sidoo kale horumarin muhiim ah oo HDL ah (heerarka wanaagsan ee kolestaroolka), in ka badan marka la qaato metformin ama placebo.
Intaa waxaa dheer, qaadashada berberine oo hoos u dhigta wadajirta testosterone oo la mid ah tan metformin.
Hagaajinta Daahfurka
In kasta oo berberine uu muujiyo faa'iidooyinka hagaajinta dhibaatooyinka dheef-shiid kiimikaadka ee PCOS, waxa kale oo uu kor u qaadi karaa bacriminta . Daraasad tijaabo ah, 98 dumar ah oo haweenka qaba PCOS ayaa la siiyay berberine. Ovulation ayaa la hagaajiyay celcelis ahaan 25 boqolkiiba 4 bilood ka dib qaadashada berberine.
Daraasad lagu daabacay Endocrinology Clinical ayaa muujisay in haweenka qaba PCOS ee si aan kala sooc lahayn loo qaato inay qaadaan berberine, waxay lahaayeen heerar uur ka sareeya metformin ama placebo iyo waxyeellooyin yar marka la qaato 12 usbuuc ka hor daaweynta IVF.
Kaalmaynta Miisaanka Culayska
Keliya haween kasta oo leh PCOS ayaa kuu sheegi kara in culeyskaagu uu sii adkaanayo kuwa qaba xaaladdan. Iyo miisaan lumis ayaa aad ugu adag sababo badan oo ay ka mid yihiin caabbinta insulinta oo kordhay, jahwareer xoog leh oo loogu talagalay carbohidratka, iyo nidaamka cuntada oo liidata.
Berberine ayaa laga yaabaa inay rajo ka qabato haweenka qaba PCOS oo ku adkaa miisaankooda. Berberine ayaa la muujiyay si loo yareeyo qarsoodiga ah ee loo yaqaan ' leptin hormone stimulating hormone'. Berberine ayaa sidoo kale muujisay in ay waxtar u leedahay caawinta miisaanka iyo fataha jidhka by by la leexiyo lipoprotein lipase enzyme, kaas oo ka masuul ah kaydinta baruurta. Waxyeelada la arkay ee qaadashada berberine ee daraasadaha intooda badani waa miisaan lumis, gaar ahaan qaybta qaybta jirka, iyo hoos u dhaca heerka hoose ee jirka (BMI).
Hoos u Dhigista Caanaha Beerka
Dumarka qaba PCOS waxay ku jirtaa halis dheeraad ah inay ku dhacdo cudurka beerka dufanka leh oo ku xiran xiriirka heerarka insulin-ta sareeya. Berberine ayaa loo soo bandhigay inuu yahay doorasho wax ku ool ah si loo yareeyo beerka dufanka leh. Dib-u-eegis ah lix tijaabo oo la xakameynayo oo la xidhiidha 500 qof, ayaa la ogaaday in berberine uu hoos u dhigo beerka dufanka leh ee ku jira kuwa qaba calaamadaha aan beerka lahayn ee beerka ku dhaca (NAFLD). Berberine wuxuu hoos u dhigey TG iyo unugyada hawlaha beerka, iyo hagaajinta guud ahaan beerka. Waxaa la ogaadey in berberine uu hagaajinayo NAFLD-yada isaga oo ka hortagaya dufanka beerka si ay kor ugu qaadaan ayna kor u qaadaan oksidiidka dufanka leh ee muruqyada qalfoofka.
Waxyaabaha Laga Baahan Yahay Berberine
Guud ahaan, berberine ayaa si fiican u dulqaadan kara, laakiin mararka qaarkood waxay keeni karaan saameyno murugo leh oo ay ku jiraan lallabbo iyo calool-istaagga, gaar ahaan marka loo isticmaalo qadar sare.
Qiyaasta daaweynta ee berberine si loo wanaajiyo insulinta iyo faa'iidooyinka kale ee la xaqiijiyay ee caafimaadku waa 500 mg, seddex jeer maalintii (oo la mid ah daawada metformin). Si looga fogaado xanuunka GI, waxa laga yaabaa inay ugu wacan tahay in si tartiib tartiib ah loogu qiyaaso 1,500mg maalin kasta adigoo qaadanaya 500 mg toddobaadkii ugu horreeyay, adoo ku daray 500 mg toddobaadkii labaad, illaa iyo intaad gaadhayso 1,500mg usbuuca saddexaad.
Berberine looma jeedin isticmaalka muddada dheer. Wax macluumaad ah lama heli karo oo ku saabsan nabadgelyada berberine ee haweenka dhallinyarada ah ama horay uurka. Berberine laguma talinayo xilliga uurka ama nuujinta.
Berberine ayaa laga yaabaa inuu wax ka beddelo beerka daawooyinka qaarkood. Digniinta waxaa lagula talinayaa haddii aad qaadato daawooyinka kale ee daawada sida daawada lidka ku ah (antidepressants) , xanuunka MAO, daawada dhiiga, iyo beta-blockers. Kormeer joogto ah oo ku saabsan baaritaanka shaqada beerka ayaa lagula talinayaa kuwa qaata berberine. Tan iyo berberine waa insulin-dareenka, waxay keeni kartaa sonkorta dhiigga oo hoos u dhacda, gaar ahaan marka lagu daro daawooyinka insulin-hoos u dhigta sida metformin ama dheellitiraad sida inositol ama n-acetylcysteine. La tasho dhakhtarkaaga kahor intaadan qaadin berberine.
> Ilo:
> Y, Sun Z, Zhang Y, Liu B, Guan Y, Lu M. Isticmaalka berberini ee loogu talagalay haweenka qaba cudurrada ugxan-yare ee ugxan-sidaha ah ee qaata daaweynta IVF. Clin Endocrinol (Oxf). 2014 Mar; 80 (3): 425-31.
> Chang X et al. Dareeraha Lipid oo ka hadlaya saameynta daaweynta ee berberine ee bukaanka qaba cudurada beerka dufanku ku badan yahay .J Transl. 2016 Sep 15; 14: 266.
> Lin L et al. Daraasad Tijaabo ah oo Tababarka Hubka ah ee Saamaynta Berberine ku saabsan Xiddiga Xiddiga, Qiimaha Koritaanka, Hormonal iyo Metabolic Qaamuusyada ee Haweenka Shooga ah ee leh Xanuunka Xanuunada ah ee Polycystic Ovarian. QAADO 2015; 10 (12): e0144072.
> Wei W, iyo al. Daraasad cilmi-baaris ah oo ku saabsan saameynta gaaban ee berberine marka la barbardhigo metformin oo ku saabsan sifooyinka jirka ee haweenka qaba cudurka kansarka ugxanta. Eur J Endocrinol. 2012 Jan: 166 (1): 99-105.
> Yang J et al. Berberine wuxuu hagaajiyaa dareenka insulin isaga oo ka ilaaliya dukaanka dufanka iyo hagaajinta astaanta adipokines ee bini'aadamka aadanaha iyo kuwa bukaanka ah ee metabolic. Isku-darka Aasaasiga ah ee Kale Iskuduwaha Med. 2012: 363845.