Alpha-ketoglutaric acid waa walax laga helo jidh ahaan. Waxaa sidoo kale laga heli karaa foomka dheeraadka ah ee dheellitirka cuntada, alfa-ketoglutaric acid door muhiim ah ka ah wareegga wareegga Krebs (taxane kiimikooyin taxane ah oo ku lug leh soo saarida tamarta jirka). Tijaabooyinka Alpha-ketoglutaric waxaa lagu faahfaahiyaa inay bixiyaan faa'iidooyin caafimaad oo kala duwan.
Alpha-ketoglutaric acid sidoo kale waxay ku dhacdaa foomka cusbada, sida walaxda loo yaqaan alpha-ketoglutarate.
Alpha-ketoglutarate waxay ku lug leedahay sameynta glutamine, amin amino ah oo loo baahan yahay soosaarista borotiinka iyo si haboon ee habka difaaca jirka.
Isticmaala
Alfa-ketoglutaric acid badanaa ayaa lagu sheegay in kor loo qaado waxqabadka ciyaaraha fudud. Caawiyayaasha dawooyinka ee badiilka ah ayaa sheeganaya in isticmaalka alfa-ketoglutaric acid ay ka caawin karto kicinta wax soo saarka jirka ee borotiinka, dejinta heerka sonkorta dhiigga inta lagu jiro jimicsiga, iyo wanaajinta adkeysiga jimicsiga.
Daawada kale, Alfa-ketoglutaric acid ayaa sidoo kale lagu sheegay in ay ka caawiso dhibaatooyinka caafimaad ee soo socda:
- caabuqa bakteeriyada
- cataracts
- cudurka kalyaha
- infekshanka khamriga
Faa'iidooyinka
Inkasta oo cilmi baaris lagu sameeyo saameynta caafimaad ee alfa-ketoglutaric acid aad u kooban tahay, baaritaano horudhac ah ayaa soo jeedinaya in alfa-ketoglutarate ay bixin karto faa'iidooyin caafimaad. Halkan fiiri natiijooyinka muhiimka ah ee laga helay daraasaddaha la heli karo:
1) Hemodialysis
Alpha-ketoglutarate waxaa laga yaabaa in ay faa'iido u tahay dadka qaada cudurka dhiigbaxa.
Daraasad lagu daabacay wargeyska Nephron ee sannadkii 1996, cilmi-baarayaashu waxay ogaadeen in la isku daro alfa-ketoglutarate iyo kalsiyum carbonate si ay bukaannada hemodialysis u caawiyaan kor u qaadista dheef-shiid kiimikaadiyaha ah iyo hoos udhaca hyperfosphatemia (xaalad calaamad u ah heerarka aan caadiga ahayn ee phosphate ee dhiiga).
2) Qalliinka Wadnaha
Alpha-ketoglutarate ayaa laga yaabaa in ay gacan ka geysato horumarinta kalyaha shaqada ee bukaannada qalliinka wadnaha, sida laga soo xigtay cilmi baaris 1998-kii oo ka yimid Annals of Thoracic Thoracic . Daraasadu waxay ku lug lahayd 22 qof oo leh hawl kelyo caadi ah ka hor inta aan la qaadin qalliinka wadnaha. Bukaannadaas, 11 qof ayaa helay faleebo faleebo ah oo ah alpha-ketoglutarate saacad ka dib qalliinkooda. Natiijooyinka daraasaddu waxay soo jeedinayaan in alfa-ketoglutarate ay kor u qaadi karto socodka dhiigga ee kelyaha.
3) Muddo dheer
Daraasad 2014-ka lagu daabacay Xog-u-sheegistu waxay soo jeedinaysaa in alfa-ketoglutarate ay muujin karto ballanqaad ku ah kordhinta muddada dheer. Baaritaannada ku saabsan duufaanka Nematode dufanka Caenorhabditis elegans , qorayaasha cilmi-baaristu waxay go'aamiyeen in alfa-ketoglutarate ay soo faragelisay wax soo saarka korontada iyo saameeya saamaynta cuntooyinka aadka u hooseeya ee kalooriyeyaasha, oo lagu muujiyey in ay kordhiyaan nolosha noolaha qaarkood. Sida laga soo xigtay qorayaasha cilmi-baarista, alfa-ketoglutarate waxay kor u qaadday heerka nolosha qiyaasaha 50% ee kontoroolka aan la daaweynin. Daraasad dheeraad ah ayaa loo baahan yahay si loo arko saamaynta ay ku yeelan karto bani'aadamka.
Qabashada
Sababtoo ah cilmi-baaris la'aanta, wax yar ayaa laga ogyahay ammaanka ammaanka muddada dheer ama isticmaalka joogtada ah ee dheeraadka ah ee ku jira kiimiko alfa-ketoglutaric.
Si kastaba ha noqotee, waxaa jira walaac ah in isticmaalka alfa-ketoglutaric acid ay ka xanaajin karto hunguriga iyo / ama caloosha caloosha.
Waa muhiim inaad maskaxda ku hayso in dheeraadka aan la tijaabin amniga iyo dheellitirka cuntada ee inta badan aan la xakamayn. Xaaladaha qaarkood, alaabtu waxay keeni kartaa qiyaaso kala duwan oo ka duwan qadarka cayiman ee geed kasta. Xaaladaha kale, sheyga waxaa laga yaabaa inuu ku sumoobo walxo kale sida birta. Sidoo kale, amniga dheeraadka ah ee haweenka uurka leh, hooyooyinka kalkaalisada, carruurta, iyo kuwa leh xaalado caafimaad ama kuwa qaadanaya daawooyinka lama dhicin.
Waxaad ka heli kartaa talooyin dheeraad ah oo ku saabsan isticmaalka dheeraadka halkan .
Bedelka
Qaar ka mid ah hababka kale ee dabiiciga ah ayaa laga yaabaa inay isticmaalaan isticmaalka ciyaaraha fudud. Tusaale ahaan, cilmi-baarisyada qaarkood waxay muujinayaan in kiimikada qatarta ah ee silsiladaha ah ay ka caawin karto hagaajinta muuqaalka jirka iyo ka hortagga daal inta mudada dheer ee jimicsiga.
Intaa waxaa dheer, dheellitirka fosfatidylserine ayaa la ogaaday in kor loo qaado awoodda jimicsiga, iyo sidoo kale hoos u dhigista xanuunka murqaha waxayna ka ilaalinayaan heerarka kororka cortisol (hormoon la sii daayay inta lagu jiro walaaca) taas oo badanaa keenta in laga hortago.
Waxaa sidoo kale jira caddaymo muujinaya in abuuruhu uu kor u qaadi karo waxqabadka xoogga badan, hawlaha mudada gaaban (sida miisaanka kor u qaadista iyo foorida).
Xaggee Laga Helaa
Waxaa laga helaa iibsashada internetka, alfa-ketoglutaric acid waxaa lagu iibiyaa dukaamo badan oo dabiici ah, dukaamada dawooyinka, iyo dukaamada ku takhasusay raashinka cuntada.
Ereyga
Iyada oo ay sabab u tahay cilmi-baaris xaddidan, waa mid aad u dhakhso badan oo lagu talinayo in lagu daro alfa-ketoglutaric acid xaalad kasta. Waxaa muhiim ah in la ogaado in is-daaweynta xaalad caafimaad leh alfa-ketoglutaric acid iyo ka fogaanshaha ama dib u dhigista daryeelka caadiga ah waxay yeelan kartaa cawaaqib xun. Haddii aad ka fikireyso inaad isticmaasho, hubso inaad la tashato dhakhtarkaaga.
Ilaha
Chin RM., Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nile M, Boq AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Re K, Jung ME, Frand AR, Huang J. "Qalabka metaboliti ee α-ketoglutarate wuxuu ku fidaa noloshii isaga oo joojinaya dabagalka ATP iyo TOR." Dabeecadda. 2014; 509 (7500). dx.doi.org/10.1038/nature13264
Jeppsson A, Ekroth R, Friberg P, Kirnö K, Milocco I, Nilsson FN, Svensson S, Wernerman J. "Dhibaatooyinka dambe ee cudurka alpha-ketoglutarate ka dib markii hawlgallada qalliinka." Ann Thorac Surg. 1998 Mar; 65 (3): 684-90.
Riedel E, Nundel M, Hampl H. "Codsiga Alpha-Ketoglutarate ee bukaannada dhiigga" hemodialysis waxay hagaajinaysaa dheef-shiid kiimikaadiyaha amino acid. " Nephron. 1996; 74 (2): 261-5.
Diidmada: Macluumaadka ku jira boggan waxaa loogu talagalay ulajeedooyinka waxbarashada oo kaliya maahan beddel talobixin, ogeysiin ama daaweyn dhakhtarka ruqsada leh. Loogama jeedo inuu daboolo dhammaan taxaddarrada suurtagalka ah, isdhexgalka daroogada, duruufaha ama saameynta xun. Waa inaad raadisaa daryeel caafimaad oo degdeg ah wixii arrimo caafimaad ah oo la tasho dhakhtarkaaga ka hor intaanad isticmaalin daawo kale ama isbeddel ku yimaada habkaada.