Rummaan , mar horeba la tixgeliyo qalaad, hadda waa mid caan ah. Casiirka roodhida waxaa laga helaa dukaanka cuntada ee ku yaala Waqooyiga Ameerika.
Laakiin warbixinta kiisaska la daabacay ee Sebtembar 1, 2006, arrinta daabacaadda 'Journal of American Cardiology' waxay soo jeedinaysaa in rummaanka uu dhexgalo daawooyinka caadiga ah.
Nin 48 jir ah ayaa qaatay Ezetimibe (Zetia®) 10 mg maalintii iyo rosuvastatin (Crestor®) 5 mg maalin kasta oo kale 17 bilood.
Labada daawo ayaa loo isticmaalaa kolestaroolka sare.
Wuxuu bilaabay inuu cabo cabitaanka rummaanka (200 ml laba jeer todobaadkii) iyo seddex isbuuc ka dib, ayaa la dhigey xaalad degdeg ah xanuun muruqa ah iyo heerka kiniinada kiniiniga ah ee sareeya (138,030 U / L, caadi ah 200 200 U / L). Labadaba waa calaamadaha rhabdomyolysis, xaalad halis ah oo sababa burburka muruqyada muruqyada waxayna keeni kartaa kalyo-xumada.
Rosuvastatin waxaa iska leh koox daawooyin loo yaqaan 'HMG-CoA reductase inhibitors', ama 'statins'. Khudaarta cagaaran ee loo yaqaan 'Grapefruit juice' ayaa loo yaqaanaa inay kordhiso khatarta miyir-beelka loo yaqaan 'statin-caused', laakiin illaa iyo hadda, waxaa jiray macluumaad yar oo ku saabsan in cabitaanka rummaanka laga yaabo inay kordhiso halista.
Casiirka roodhida iyo casiirka sharaabka, labadaba waa la og yahay in lagu xakameeyo nidaamka cytochrome P450 3A4 enzyme ee mindhicirka. Iyada oo la xakameynayo enzymes-ka, casiirku wuxuu kordhin karaa heerarka dhiigga ee daawooyinka badan.
Isdhexgalka Mukhaadaraadka-Mukhaadaraadka
- Antiarrhythmics - Amiodarone (Cordarone®), Disopyramide (Norpace®), quinidine
- Calcium channel blockers - Felodipine (Plendil®), nicardipine (Cardene®), nifedipine (Procardia®), nimodipine (Nimotop®), nisoldipine (Sular®)
- Statins - Atorvastatin (Lipitor®), lovastatin (Mevacor®), simvastatin (Zocor®)
- Immunosuppressants - Cyclosporine (Sandimmune®, Neoral®), takrolimus (Prograf®)
- Kaadi-saareyaasha Protease - Saquinavir (Fortovase®)
Si kastaba ha ahaatee, cabitaanka rummaanka ayaa sidoo kale la macaamili kara daawooyinka aan ku jirin liistadaan.
Daawooyinka ezetimibe iyo rosuvastatin looma maleeynayo in la jabiyo cytochrome P450 3A4.
Iyada oo ku saleysan caddayn xadidan oo ku saabsan isdhexgalka daroogada, waxaa lagama maarmaan ah in aad la hadasho dhakhtarkaaga haddii aad qaadato daawo oo aad ka fekereyso inaad cabto cabitaanka rummaanka.
Ilaha:
Waxyaabaha Macaamiisha ah ee Cytochrome P450 3A (CYP3A) iyo farmashokinikada carbamazepine ee jiirka. Dheef-shiid kiimikaad iyo qashqashaad. 33.5 (2005): 644-8.
Kim H, Yoon YJ, Shon JH, Cha IJ, Shin JG, Liu KH. Dhibaatooyinka xaddidan ee miro khudradda on hawlaha CYP3A. Dheef-shiid kiimikaad iyo qashqashaad. 34.4 (2006): 521-3.
Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis oo la xiriira isticmaalka cabitaanka rummaanka. Somali Journal of Cardiology. 98.5 (2006): 705-6.
Diidmada: Macluumaadka ku jira boggan waxaa loogu talagalay ulajeedooyinka waxbarashada oo kaliya maahan beddel talobixin, ogeysiin ama daaweyn dhakhtarka ruqsada leh. Loogama jeedo inuu daboolo dhammaan taxaddarrada suurtagalka ah, isdhexgalka daroogada, duruufaha ama saameynta xun. Waa inaad raadisaa daryeel caafimaad oo degdeg ah wixii arrimo caafimaad ah oo la tasho dhakhtarkaaga ka hor intaanad isticmaalin daawo kale ama isbeddel ku yimaada habkaada.