Cudurka khudradda ah ee loo yaqaan "Cruciferous-Vegetable Compound" ka ayaa ka caawiya Kansarka Kansarka?
Diindolylmethane waa walxo dabiici ah oo soo baxa marka jirku jebiyo indole-3-carbinol, oo ah unug laga helo khudaarta cagaaran sida broccoli iyo kale. Waxaa lagu heli karaa foomka dheeraadka ah, diindolylmethane waxaa la yiraahdaa inuu bixiyo noocyo badan oo faa'iidooyin caafimaad ah.
Waa maxay sababta ay dadku u qaadanayaan
Diindolylmethane waxaa loo kala saaraa inuu soo saaro isbeddel ku yimaadda dheef-shiid kiimikaad (estrogens metabolism), geedi socodka bayoolajiga oo loo maleynayo in uu saameyn ku yeelanayo kansarrada hormoon-ka-guurka ah sida kansarka naasaha.
Bixiyeyaashu waxay ku andacoodaan in diindolylmethane ay ka caawin karto inuu kordhiyo difaacaada ka hortaga dhawr nooc oo kansar ah, iyo sidoo kale kor u qaadista xasaasiyadda iyo taageeridda miisaanka.
Faa'iidooyinka
Ilaa hadda, baaritaan ku saabsan saameynta caafimaad ee diindolylmethane waa mid xadidan. Daraasad horudhac ah, aqoonyahanno badan ayaa ogaaday in diinolylmethane ay saameyn karto dheef-shiid kiimikaad ee estrogen.
Inkasta oo loo maleynayo in wax laga beddelo shucaaca estrogen ay ka caawin karto ka ilaalinta kansarrada hormoonka ku ah (sida kansarka naasaha), ma jirto baadhitaan ku filan oo lagu ogaanayo in diindolylmethane uu ka caawin karo ka hortagga kansarka.
Halkan fiiri qaar ka mid ah natiijooyinka muhiimka ah ee daraasaddan la heli karo:
1) Kansarka Naasaha
Inkastoo baaritaannada shaybaarka qaarkood ay soo jeedinayaan in diindolylmethane ay ka hortagi karto kobaca unugyada kansarka naasaha, waxaa jira daraasado kiliinikaro ah oo yar.
Daraasad tijaabo yar oo 2004 ah oo lagu daabacay Nafaqada iyo Kansarka , cilmi baarayaashu waxay ogaadeen in qaadashada daawada diindolylmethane ay keentay isbedelka dheef-shiid kiimikaad ee estrogen.
Daraasadu waxay ku hawlanayd 19 haween ah oo haweenka uurka ku jira oo leh taariikh hore ee kansarka naasaha.
Daraasad cilmi baaris ah oo lagu daabacay Kansarka Qoyska 2015 ayaa baaray isticmaalka 300 mg maalintii diindolylmethane muddo afar illaa lix toddobaad ah oo ah shan iyo toban haween ah oo leh mutacal BRCA1. Isbedelka estrogen ee kaadida (biomarker oo ku xiran kobaca kansarka naasaha) ma si weyn u badalin ka dib marka la dheereeyo.
2) Kansarka ku dhaca ilmagaleenka
Inkasta oo xogta qaarkood ay soo jeedisay in qaadashada dheereeya diindolylmethane ay hoos u dhigi karto horumarka kansarka ilma-mareenka, cilmi-baaris 2012 ah oo lagu daabacay Wargeyska Ingiriiska ee Kansarka ayaa ku fashilmay inuu muujiyo wax faa'iido ah. Daraasadu waxay ku lug lahayd 551 haween ah oo leh cudurka cusub ee la ogaado, heerka cilladda-hoose ee unugyada ilmo-galeenka. Muddo lix bilood ah, kaqeybgalayaashu waxay qaateen qaybo kale oo diindolylmethane ah ama maalin kasta. Daawooyinka diindolylmethane ayaa ku fashilmay inay yeeshaan saameyn faa'iido leh oo ku-ool ah isbeddelada unugyada xubinta taranka ama joogitaanka HPV.
3) Noocyada kale ee Kansarka
Natiijooyinka hordhaca ah ee ka soo baxa baaritaanada tubaakada iyo baarista xayawaanka ku salaysan ayaa muujinaya in diindolylmethane laga yaabo inay bixiso qaar ka hortag ah kansarka qanjirada , kansarka ugxanta, iyo kansarka mindhicirka . Si kastaba ha noqotee, baaritaan la'aan la'aanta, waa wax aad u yar in la sheego in diindolylmethane uu ka caawin karo in uu la dagaallamo noocyada kansarka ee aadanaha.
4) Dhimashada Miisaanka
Inkastoo diindolylmethane supplements waxaa mararka qaarkood lagu tiriyaa sida qalabka luminta lumista, ma jirto caddayn cilmi ah oo lagu taageerayo sheegashada qaadashada diindolylmethane kor u qaadista miisaanka.
Ilaha
Diindolylmethane waxaa la soo saaraa marka jirku khafiifiyo indole-3-carbinol, kaas oo laga helay khudaarta soo socota:
- Brokoli
- Sprouts
- Kaabashka
- Gawsoorka
- Cagaarka Collard
- Kale
- Cagaarka qasabka ah
- Biyaha Biyaha
Diindolylmethane ayaa sidoo kale laga heli karaa foomka dheeraadka ah, oo lagu iibiyo dukaamada cuntada lagu iibiyo iyo dukaamada ku takhasusay raashinka cuntada.
Waxyeelooyinka Laga Helo
Ilaa imminka, wax aad u yaryar ayaa lagu yaqaanaa amaanka isticmaalka diindolylmethane si joogta ah ama muddo dheer.
Sababtoo ah diindolylmethane ee awoodda u leh saameynta dheef-shiid kiimikaad (estrogen), waxaa jira walaac ah in qaadashada diindolylmethane supplements ay sii xumayn karto xaaladaha hormoonka-xasaasiga ah (oo ay ka mid yihiin kansarrada hormoon-ku-tiirsan, endometriosis , iyo fareebaha uterineine ).
Sida laga soo xigtay mid ka mid ah warbixinta, haweeney caafimaad oo kale ayaa ka warramey xariga dhexe ee chorioretinopathy (xaalad keentay aragti la'aan) ka dib markii ay qaadatay maalintii oo dhan maalin diindolylmethane muddo laba bilood ah.
Ka dib markii la joojiyo waxtarrada, astaamaheeda ayaa la xaliyay sideed todobaad. Maqaarka finanka leh eosinophilia (heerarka kor loo qaado ee eosinophils oo inta badan ku dhaco jawaab celinta noocyada fal-celinta xasaasiyadda ama fal-celinta daroogada) ayaa la soo sheegay ka dib isticmaalka diindolylmethane. Murqaha iyo xanuunka wadajirka ah, gaar ahaan miskaha iyo jilbaha, ayaa la soo sheegay.
Marka la eego welwelka amniga, waxaa muhiim ah in la raadsado talo caafimaad kahor intaan la isticmaalin daawooyinka diindolylmethane. Dumarka uurka leh ama kalkaalisada waa in aysan qaadan daawooyinka diindolylmethane. Sidoo kale, dadka loo daaweeyo kansarka waa inaysan qaadanin.
Waxaad heli kartaa talooyin dheeraad ah oo ku saabsan isticmaalka dheeraadka halkan , laakiin waxaa muhiim ah in la ogaado in is-daaweynta xaalad joogta ah oo leh diindolylmethane iyo ka fogaanshaha ama dib u dhigista daryeelka caadiga ah waxay yeelan kartaa cawaaqib culus.
Qaadashada
Sababtoo ah la'aanta taageero cilmi ah, waa mid aad u dhakhso badan oo kugula talineysa daawooyinka diindolylmethane sida daaweyn caadi ah xaalad kasta oo caafimaad.
Hase yeeshee, kordhinta heerarka diindolylmethane adiga oo ku jiro indole-3-carbinol-ku jira khudaarta cagaaran ee ku jirta cuntadaada ayaa kaa caawin karta hagaajinta caafimaadka guud. Khudaarta cagaaran waxay hodan ku yihiin tiro badan oo ah walxaha kor u qaadaya caafimaadka, oo ay ku jiraan antioxidants.
Ilaha
Castañon A, Tristram A, Mesher D, iyo al. Saameynta dib-u-cadeeynta diindolylmethane ee ku-ooloodka-hoose ee ilmo-galeenka ee afka ilmagaleenka: laba-indho la ' Br J Cancer. 2012 Jan 3; 106 (1): 45-52. doi: 10.1038 / bjc.2011.496.
Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF. Daraasada Pilot: Saamaynta 3,3'-diindolylmethane ee dheecaanka metaboleedyada kaadimareenka ee dumarka postmenopausal oo leh taariikh hore ee kansarka naasaha. Kansarka Naas. 2004; 50 (2): 161-7.
Nikitina D, Llacuachaqui M, Sepkovic D, iyo al. Saameynta kaabayaasha 3,3'-diindolylmethane ee kudhowaad 2: 16a-OHE ee xayawaanka mutaweel-ka BRCA1. Cancer Fam 2015 Jun; 14 (2): 281-6. doi: 10.1007 / s10689-015-9783-2.
Smith S, Sepkovic D, Bradlow HL, Auborn KJ. 3,3'-Diindolylmethane iyo genistein waxay hoos u dhigtaa saameynta xun ee estrogen ee LNCaP iyo unugyada kansarka qanjirka 'PC-3'. J Nutr. 2008 Dec; 138 (12): 2379-85.
Staub RE, Onisko B, Bjeldanes LF. Qeybta 3,3'-diindolylmethane ee ku jirta unugyada kansarka naasaha MCF-7 Chem Res Toxicol. 2006 Mar; 19 (3): 436-42.
Diidmada: Macluumaadka ku jira boggan waxaa loogu talagalay ulajeedooyinka waxbarashada oo kaliya maahan beddel talobixin, ogeysiin ama daaweyn dhakhtarka ruqsada leh. Loogama jeedo inuu daboolo dhammaan taxaddarrada suurtagalka ah, isdhexgalka daroogada, duruufaha ama saameynta xun. Waa inaad raadisaa daryeel caafimaad oo degdeg ah wixii arrimo caafimaad ah oo la tasho dhakhtarkaaga ka hor intaanad isticmaalin daawo kale ama isbeddel ku yimaada habkaada.