Waa maxay Cilmi-baadhista
Marijuana caafimaadku waa arrin muran ah-bulsho ahaan, sharci ahaan, iyo siyaasad ahaanba. Si kastaba ha ahaatee, caddaynta cilmi-baarista waxay sii wadaysaa faahfaahin ku saabsan in ay noqon karto daaweyn sugan oo wax ku ool ah xaalado badan oo xanuun ah, oo ay ku jiraan fibromyalgia .
Waxaanu leenahay qaababka qoraalka ah ee tetrahydrocannabinol (THC) ee suuqa, taas oo ah walax la xidhiidha "sare" marijuana.
Daraasaduhu waxay soo jeedinayaan, inkastoo, xeryaha kale ee dhirta laga yaabo in ay leeyihiin qiime daaweyn.
Ka hor inta aan laga hadlin saamaynta gaarka ah ee marijuuca daawada fibromyalgia, waxay ka caawineysaa in wax yar laga ogaado wax la yiraahdo cannabinoid endogen, ama endocannabinoid, nidaamka.
Waa maxay nidaamka Endocannabinoid?
"Dhibaato" waxaa loola jeedaa wax ka soo baxa jidhkaaga - wax caadi ah halkaas.
"Cannabinoid" waxay ka timaaddaa ereyga cannabis, taas oo ah magaca farsamada ah ee warshadda marijuana, waxayna loola jeedaa qaybo ka mid ah jidhkaaga oo ka soo horjeeda xashiishka. Dhammaanteen waxaan leenahay jidhkeena dabiiciga ah ee jidhkeena, iyo in badan oo sigaar ah lagu soo bandhigi karo ama la cuni karo marijuana ama noocyada synthetic ee.
Nidaamka endocannabinoid wuxuu ku lug yeeshaa geeddi-socod badan, kuwaas oo intooda badan la yaqaan ama loo aqoonsan yahay in ay waxyeelleynayaan fibromyalgia. Kuwaas waxaa ka mid ah:
- Dheef-shiid kiimikaadka
- Waxqabadka difaaca
- Xusuusin
- Hawlaha xanuunka
- Hurdada
- Jawaabta kadeedka ah
- Xeer-dejinta heerkulka
- Nidaamka dareenka madaxbannaan
Qoraal 2004 ah oo ku saabsan nidaamka endocannabinoid ayaa soo jeediyay in fibromyalgia, cilladda mindhicirrada xanuunka, iyo xaaladaha la xidhiidha loo yaqaan "calaamadaha endocannabinoid la'aanta '. Waxay sidoo kale qeexaysaa cilmi-baarisyo ku saabsan dhibaatooyinka caqabadaha ku ah shisoofrani, calaamado badan oo maskaxda ah, cudurka Huntington, xaaladaha qaarkood ee cudurka Parkinson, xaaladaha qaarkood ee anorexia, iyo jirro joogto ah.
Qaybta koreysa ee cilmi-baarista oo muujinaysa in fibromyalgia ay ku lug leedahay khalkhalka ku jira endocannabinoids waxay keentaa su'aallo cad: kor u qaada xaddiga cannabinoids ee jirka ka caawiya inuu hagaajiyo shaqada oo uu yareeyo astaamaha? Hadday sidaas tahay, astaamaha cagaarshowga (ama kuwa isku dhafan) ayaa yareeya miisaanka?
Cilmi-baaris ku saabsan Caafimaadka Marijuana & Fibromyalgia
Dib-u-eegis 2014 ah oo cilmi baaris ah oo ku saabsan marijuana loogu talagalay daawaynta fibromyalgia, iyo sidoo kale xaaladaha la xiriira xaaladaha mindhicirka mindhicirka iyo xannuunjafka, waxay soo jeediyeen:
- Dhibaatooyinka Endocannabinoid waxay door ka ciyaaraan xaaladahaas
- Marijuana waxay awood u leedahay in ay xakameeyso qaababka xanuunka lafdhabarta, xannuunka iyo caloosha
- Waayo-aragnimada bukaan-socodka ayaa xaqiijinaysa natiijooyinkan
Daraasaduhu waxay soo jeedinayaan in marijuana si weyn u awood u yeelan karo:
- Yaree xanuunka (oo ay ku jiraan xanuunka nociceptive, oo ah qayb ka mid ah fibromyalgia)
- Iska yaree adkaanshaha
- Bararka hooseeya (oo ay ku jiraan infakshan macaan, oo laga yaabo inuu door ka ciyaaro fibromyalgia)
- Horumarinta nasashada
- Kordhi hurdo la'aanta
- Kordhinta dareenka wanaaga
Mid ka mid ah daraasaddan ayaa sidoo kale aragtay in dadka isticmaala cannabis ay leeyihiin dhibco caafimaad oo aad u sarreeya marka loo eego dadka aan isticmaalin. Mid kale, oo eegay saameynta bir cannabinoid loo yaqaan 'cannabinoid' oo la yiraahdo nabilone, ayaa muujinaysa in qiyaas yar oo habeenkii ah ay kor u qaadi karto hurdada fibromyalgia waxaana loo tixgelin karaa beddelka daawada amitriptyant ee caanka ah.
Daraasada 2012 ayaa waxay eegtey in baahida loo qabo marijuana isticmaalka fibromyalgia. Cilmi baadhayaashu waxay ogaadeen in qiyaastii boqolkiiba 13 ka mid ah kaqeybgaleyaashu ay isticmaalayeen daroogada si ay uga caawiyaan ciribtirka calaamadaha Kuwaasi, in ka badan 80 boqolkiiba ayaa si sharci ah u isticmaala.
Cilmi baadhayaashu waxay sidoo kale ogaadeen in isticmaalka marijuuca uu aad ugu dhow yahay bukaanada fibromyalgia oo leh jirro maskaxeed oo aan degganeyn. Xidhiidhka u dhexeeya marijuana iyo cudurka maskaxda ee kooxdan lama yaqaan.
Marijuana waxay sidoo kale isticmaali jirtay ragga, dadka shaqo la'aanta ah, iyo kuwa qaata lacagaha naafada.
Waxyaabaha kale ee saameynaya
Dib-u-eegista 2011-ka ayaa sheegay in cannabinoids ay u muuqdaan kuwo nabdoon oo ay la xiriiraan waxyeelo fudud ama dhexdhexaad ah kuwaas oo guud ahaan si wanaagsan loo dulqaatay, iyo in heerarka hoos-u-dhaca ay sabab u tahay dhibaatooyinka soo raaca.
Dhibaatooyinka la soo sheegey waxaa ka mid ah:
- Dawakhaad
- Lalabbo
- Afka qalalan
- Ataxia (yaraynta xakameynta dhaqdhaqaaqa jirka)
Si kastaba ha ahaatee, daraasadda 2014 ayaa tilmaameysa in aan u baahannahay daraasado wakhti dheer ah si aan u ogaano waxa saameynaha wakhti dheer ku iman kara, iyo sidoo kale halisaha iman kara si xun u isticmaalka iyo takoorka.
Dawooyinka Marijuana-ku-saleysan
Qaar ka mid ah foomamka caanoodka ee marijuana waxay ku yaalaan suuqa Maraykanka ee daroogooyinkaas waxaa ka mid ah:
- Marinol (dronabinol)
- Cesamet (nabilone)
Mashiinka caafimaadku waa mid sharci ah oo ku yaal dhowr gobol. Noockan daroogada ah waa la cabi karaa, cuno (sida alaab la dubay), ama uumiga. Cunnooyinka ama qaababka la googooyey ayaa laga yaabaa inay ammaanaan oo ay u sahlanaadaan dadka qaarkood inay u dulqaataan.
Sababtoo ah helitaankeeda daroogada madadaalada ah, dadka qaarkood waxay doortaan inay si sharci darro ah ula dhaqmaan marijuana. Tani waxay la timaaddaa khataraheeda, oo ay ka mid yihiin:
- In la xiro, lagu soo oogo oo lagu helo dambi
- Helitaanka marijanaada leh walxo halis ah oo ay ku jiraan
- Qaadashada alaab aan rasmi ahayn
Dadka isticmaala marijuana si sharci-darro ah ayaa sidoo kale u diidaya inay u sheegaan bixiyeyaashooda caafimaadka. Tani waxay keeni kartaa dhibaatooyin la xiriira isdhexgalka daroogada ama, haddii ay dhacdo fal-celin xun oo daran, waxay sababi kartaa dhakhtarrada inay khaldan yihiin arrinta. Badbaadadaada, waa inaad mar walba u sheegtaa dhakhtarkaaga iyo farmashiistaha dhamaan daroogooyinka aad qaadatid.
Noocyada kale ee daaweynta Endocannabinoid
Cilmi-baaris ayaa soo jeedinaysa in dawooyin badan, labadaba rijeeto iyo rikoodhka labadaba, ay saameeyaan habka dhameystiran ee loo yaqaan endocannabinoid. Kuwaas waxaa ka mid ah:
- Painkillers ( acetaminophen , NSAIDs , opioids , glucocorticoids)
- Dawooyinka liddi ku ah antidepressants ( amitriptyline , duloxetine )
- Ciladaha dhimirka
- Daawooyinka welwelka
- Daawooyinka la-qabqabashada ( pregabalin , gabapentin)
Daawooyinka aan dawooyinka ahayn ee laga yaabo inay waxtar yeeshaan waxaa ka mid ah:
- Massage
- Isku-dhafashada miyir-qabka
- Acupuncture
- Kombiyuutarada
- Dawooyinka dhirta
Qodobada hab-nololeedka oo ay ku jiraan cunto iyo jimicsi ayaa sidoo kale keeni kara isbeddelka nidaamka endocannabinoid. Sida hab daaweyn ama hab maamul, waa inaad la hadashaa dhakhtarkaaga wixii ku saabsan sida ugu fiican ee adiga kugu habboon.
Ilaha:
Benyamina A, Reynaud M. La soo dhaweynta. 2014 Feb; 64 (2): 165-8. (Qodobka Faransiiska ah ee loo yaqaan "Abstract referenced.") Isticmaalida daaweynta xashiishadda cannabis.
Fiz J, iyo al. QAADO 2011 Apr 21; 6 (4): e18440. Cannabis ayaa isticmaala bukaanada qaba fibromyalgia: waxay saameyn ku leedahay calaamadaha gargaarka iyo tayada caafimaad ee la xiriirta nolosha.
Lynch ME, Campbell F. British Journal of pharmacology. 2011 Nov; 72 (5): 735-44. Cannabinoids oo loogu talagalay daaweynta xanuunka aan joogtada ahayn ee kansarka; dib-u-eegis nidaamsan ee tijaabooyin la kala doortay.
McPartland JM. Wargeyska shaqada jirka iyo dhaqdhaqaaqa dhaqdhaqaaqa. 2008 Apr; 12 (2): 169-82. Muujinta habka endocannabinoid ee fibroblasts iyo unugyada makaanka.
McPartland JM, Guy GW, Di Marzo V. 2014 Mar 12; 9 (3): e89566. Daryeelka iyo quudinta nidaamka endocannabinoid: dib-u-eegis nidaamsan ee waxqabadyada daaweyneed ee suurtagalka ah ee xakameynaya nidaamka endocannabinoid.
Russo EB. Waraaqaha qanjirada neuro. 2004 Feb-Apr; 25 (1-2): 31-9. CECD: Fikradani ma sharxi kartaa faa'iidooyinka daaweynta ee cannabis ee migreebka, fibromyalgia, cilladda mindhicirrada xanuunka iyo xaalado kale oo daaweyn u adkeysi leh?
Smith Smith, Wagner MS. Waraaqaha 'Neuor Endocrinology'. 2014; 35 (3): 198-201. Dib u soo noqoshada kiliinikada caafimaad (CEC D) dib u soo noqoshada: fikradani ma sharxi kartaa faa'iidooyinka daaweynta ee cannabis ee ku saabsan xannuunnada maskaxda, fibromyalgia, xanuunka mindhicirka ee xanuunka iyo xaalado kale oo daaweyn u adkeysi leh?
Ste-Marie PA, iyo al. Daryeelka xinjirta iyo cilmi baarista. 2012 Aug; 64 (8): 1202-8. Ururka xashiishada cannabis ayaa adeegsanaya xuduudaha nafsaaniga ah ee dadka qaba fibromyalgia.
Ware MA, iyo al. Suuxdinta iyo xanuunada. 2010 Feb 1; 110 (2): 604-10. Saameynta nibbada oo ku seexanaysa fibromyalgia: natiijooyinka tijaabada kontoroolka la xaddiday.