Qaar ka mid ah daawooyinka aad u qaadato xaalado caafimaad oo kale, sida cadaadiska dhiigga sareeya ama daaweynta hoormoonka - waxay si xun u saamayn kartaa heerarka lipid. Tani waxaa ka mid noqon kara kordhinta heerarka LDL iyo triglyceride ama hoos u dhigidda kolestaroolkaaga HDL. Tani waxay noqon kartaa mid dhib badan haddii aanad marnaba ka walwalin kolestaroolka ka hor. Intaa waxaa dheer, haddii aad hadda daawooyinka u leedahay si loo yareeyo kolestaroolkaaga, waxaad ogaan kartaa in daweyntaada ay ubaahantahay in la hagaajiyo.
Inkastoo tani aysan ahayn liis loo dhan yahay, daawooyinka hoos ku taxan ayaa ah daawooyinka aadka loo isticmaalo ee laga yaabo inay saameyn karaan heerarka lipid-kaaga. Waa inaad mar walba u sheegtaa bixiyahaaga daryeelka caafimaadka daawooyinka aad qaadatid, sidaa darteed isaga ama iyada ayaa ka hadli kara haddii daawooyinka ama alaabooyinka dabiiciga ahi ay saameyn xun ku yeelanayaan caafimaadkaaga:
Prednisone
Prednisone waa glucocorticoid oo loo isticmaalo in lagu yareeyo bararka, diirimaadka, iyo jilicsanaanta la xidhiidha xaalado fara badan. In kasta oo gargaarka laga yaabo inay ku siiyaan, waxay kor u qaadi karaan triglycerides, heerarka LDL ee kolesteroolka, iyo heerarka HDL ee kolestaroolka. Ma qaadanayso waqti dheer si aad u aragto kor u kaca heerarka kolestaroolka: Daraasadaha qaarkood waxay muujiyeen in bukaanku uu leeyahay heerar barar sare oo ka sareeya laba toddobaad oo daaweyn ah.
Beta Blockers
Beta blockers waa daawooyin sida caadiga ah loo qoro si loo daweeyo cadaadiska dhiig karka. In kasta oo faa'iidooyinka muhiimka ah, ay bixiyaan daaweynta noocyo badan oo cudur wadne ah, beta blockers ayaa sidoo kale loo arkay in la yareeyo heerarka HDL iyo heerarka triglyceride sare.
Xaaladaha badankood, hase yeeshee, isbeddelladaas lipid waxay ahaayeen kuwo aad u yar. Waxaa muhiim ah in la xusuusto in dhammaan beta-blockers-ka aysan saameyn ku yeelan. Beta-blocker soo socda ayaa loo arkay in waxoogaa isbeddelaan hababka lipid:
- Atenolol (Tenormin®)
- Bisoprolol (Zebeta®)
- Metoprolol (Toprol®, Lopressor®)
- Nadolol (Corgard ®)
- Propanolol (Inderal ®)
Beta-blockers ma aha oo kaliya inay caawiso hoos u dhigidda cadaadiska dhiigga, waxay sidoo kale yihiin qalab loogu talagalay in la sii wado badbaadinta dadka qaba cudurka wadnaha oo firfircoon (sida wadnaha wadnaha oo shaqaynaya iyo wadna xanuun). Sidaa daraadeed, xitaa haddii waxoogaa isbeddel ah ee lipids-ka lagu arkay, waxaa muhiim ah in beta-blockers-ka aan la joojin.
Amiodarone
Amiodarone waa daawo loo isticmaalo in lagu daweeyo noocyo kaladuwan oo wadnaha ah waxaana lala xiriiriyaa waxyeelo badan oo soo raaca. Mid ka mid ah saameynada yaryar ee yar waxay la xiriirtaa kolestaroolka sare . Amiodarone ayaa inta badan kor u qaaday heerarka LDL ee kolesteroolka laakiin ma muuqanayso inay saameyn ku yeelaneyso heerarka HDL ee kolestaroolka ama triglyceride.
Estrogen
Estrogen waa hormoon dumar ah oo laga helo xakameynta dhalmada hormoonka haweenka iyo hababka kale ee daaweynta hormoonka bedelida. Sannado badan, estrogen ayaa loo tixgeliyey "wadnaha wadnaha," sidaas darteed kor u qaadida wadnaha caafimaadka leh . Tani waxay badanaa sabab u tahay awoodda ay u leeyihiin inay kor u qaadaan heerka HDL. Tani waxay keentay in haween badan oo haweenka uurka ku jira ay qaataan daaweynta hoormoonka si loo caawiyo qalbigooda. Hase yeeshee, daraasadihii ugu dambeeyay ayaa lagu ogaaday in aysan ka difaacin cudurrada wadnaha ka dib markii caado wadata. Farsamada ay keento weerarrada wadnaha lama garanayo.
Intaa waxaa dheer, estrogens waxay sidoo kale kordhin kartaa heerarka triglyceride.
Progestin
Progestin waa nooc ka mid ah progesterone, hormoon kale oo dumar ah, oo loo isticmaalo ka hortagga uur-qaadidda afka iyo daaweynta hoormoonka beddelida kali ama keligood oo lagu daro estrogen. Heerarka sare ee progestin ayaa lala xiriiriyay heerka HDL hooseysa. Iyadoo lagu daro estrogen, progestin ayaa joojin karta saameynta caafimaadka ootrogen ee kor u qaadeysa heerarka HDL.
Cudurka Anabolic
Cudurka anabolic waxaa ka mid ah testosterone, hormoonka galmada ee loo isticmaalo in lagu daaweeyo qaangaarnimada da 'yar ee wiilasha iyo qaababka aan awoodin. Waxaa sidoo kale loo isticmaalaa si sharci daro ah si loo dhiso qulqulka murqaha.
Daroogooyinkaasi waxay sare u qaadaan heerarka LDL iyo heerka HDL hoos udhaca. Saameynaha waxyeelada leh ee daroogadaasi ku aaddan heerarka kolestaroolka ayaa ah kuwo badan oo laga ogaado daawooyinka afka laga qaato marka la barbardhigo daawooyinka laysku duro.
Cyclosporine
Cyclosporine (Sandimmune®, Neoral®, Gengraf®) waa daroogo loo isticmaalo in lagu xakameeyo habka difaaca jirka. Waxaa badanaa la isticmaalaa ka dib marka xubin jirka laga bedelo si looga hortago diidmada. Si kastaba ha ahaatee, waxaa sidoo kale loo isticmaali karaa in lagu daweeyo rheumatoid arthritis iyo psoriasis. Daraasaduhu waxay muujiyeen in salka loo yaqaan "cyclosporine" kor u qaada heerarka "kolesterol" LDL.
Cadaadiska Protease
Kaadi-saareyaasha xaddidan ayaa loo isticmaalaa in lagu daaweeyo fayraska jirka ee difaaca jirka (HIV). In kastoo habka ay dawooyinkani kor u qaadaan heerka kolestaroolka, haddana waxay u muuqdaan inay gaaraan heerarka triglyceride iyo heerarka HDL ee hoos u dhacsan. Fibrates iyo statins ayaa mararka qaarkood loo adeegsadaa si loo yareeyo triglycerides oo kordhiya heerka HDL ee shakhsiyaadka qaadaya daawooyinkan.
Diuretics
Diuretics waxaa loo isticmaalaa in lagu daaweeyo cadaadiska dhiigga sare iyo haynta biyaha. Waxaa jira laba nooc oo ah dheecaan (diuretics) oo keena heerarka kolesteroolka kordhiya:
- Diyuritiyada Thiazide (oo ay ku jiraan hydrochlorothiazide, chlorothiazide, metolazone)
- Cirbadaha sambabada (oo ay ku jiraan furosemide, torsemide, bumetanide)
Cudurka diidmadda Thiazide wuxuu sababaa koror ku meel gaar ah oo ah wadarta guud ee kolestaroolka, heerarka triglyceride, iyo heerarka kolestaroolka LDL. Heerarka baruurta ee HDL ma aha kuwo sida caadiga ah waxyeello u geysta. Korodhkaasi wuxuu u dhexeeyaa inta u dhaxaysa 5 ilaa 10 milligrams per deciliter. Waqtigaan, indapamide waa dhuriga xuubka ee kaliya ee aan la muujin in si xun u saameeyo heerarka lipid. Cirbadeynta sambabada ayaa la wadaagaya qaab isku mid ah oo loo yaqaan 'thiazide diuretics'; hase yeeshee, qaar ka mid ah daawooyinkaas ayaa muujiyay hoos u dhac ku yimid kolestaroolka HDL. Maadaama bacruriyaddu ay aad muhiim ugu tahay daaweynta hoos u dhigista cadaadiska dhiigga, bixiyahaaga daryeelka caafimaad ayaa sidoo kale ku siin kara cunto yar oo dufan ah inta aad dawadan qaadato.
Haddii aad qabtid heerar sare oo kolestaroole ah oo aad qaadanayso daawo taas oo suurtogal ah in aad sare u qaaddo heerarka dhiiggaaga, waxaa laga yaabaa in bixiyahaaga daryeelka caafimaad uu rabo in uu si joogto ah ula socdo dhiigaaga si loo hubiyo in heerkaagu uu aad u sarreeyo. Xaaladaha qaarkood, saameynta xun ee lipids waxay noqon kartaa mid ku meel gaar ah. Si kastaba ha noqotee, haddii ay sii wadaan inay sare u kacaan kadib marka daaweyntu bilowdo, bixiyahaaga daryeelka caafimaad ayaa laga yaabaa inuu go'aansado inuu ku daro ama wax ka beddelo daaweyntaada baruurta yar-yar.
Ilaha:
Dipiro JT, Talbert RL. Farmashoterapi: Habka Pathophysiological, 9th ed 2014.
> Warbixinta Saddexaad ee Barnaamijka Waxbarashada Xoolaha ee Qaranka (NCEP) Guddi Khabiir ah oo lagu ogaanayo Qiimeynta, Qiimeynta, iyo Daaweynta Dhiiga Dhiigga Dhiig badan ee Dadka waawayn (PDF), Julaay 2004, Machadyada Qaranka ee Caafimaadka: Machadka Wadnaha, Sambabka, iyo Dhiigga Qaranka.
Micromedex 2.0. Truven Health Analytics, Inc Greenwood Village, CO. Http://www.micromedexsolutions.com.