Sidee ufudud ufudud oo sahlan u keeni kartaa daaweyntaada HIV?
Mindhicirku wuxuu u eg yahay dadka caadiga ah ee qaba HIV maxaa yeelay waa dadweynaha guud. Inkastoo ay jiraan tiro badan oo rijeeto leh iyo daawooyinka ka soo horjeeda miyir-qoyseedka si loo daaweeyo xummad, qaar ayaa la yaqaan in ay la macaamilaan daawooyinka HIV , inta badan waxay yareeyaan bioavailability (helitaanka dhiigga).
Saameyntani waxay dhici kartaa marka daawooyinka la qaato waqti isku mid ah.
Tani waa sababta oo ah saamiyo kasta oo la mid ah waddooyinka kale ee loo qaybiyo jirka. Tartankan ayaa mararka qaar hoos u dhigi kara heerka daroogada HIV ee dhiigga, taas oo macnaheedu yahay in ay jirto daroogo yar oo la heli karo si loo xakameeyo fayruuska xorta ah ee wareegaya.
Xaaladaha qaarkood, soo-horjeedka ayaa dhici kara, taasoo keenaysa kororka bioavailability iyo sidoo kale kordhinta sunta iyo saameynta daawada.
Fahmidda Jidhka
Xanuun-xummad-calaamad muujinaysa xaaladda caafimaad ee loo yaqaan 'gastroesophageal reflux disease' (GERD) - sababtoo ah marka asaasiga caloosha (dib -u-celinta) dib ugu laabto hunguriga. Xagga ka baxsan xiniinyaha, calaamadaha GERD waxay ku jiri karaan:
- Cune xanuun
- Dib u dhac
- Afar dhadhanka afka ah
- Dareemid barar ku dhaca cunaha
- Qufac aan caadi ahayn, oo aan waxtar lahayn
- Hoos-u-dhac ama laryngitis
Haddii qofku qabo miyir-beel sababtoo ah GERD, noocyada daawooyinka qaarkood ayaa laga yaabaa in loo qoro, oo ay ku jiraan mashiinka proton-ka iyo H2-da kuwaas oo yareeya geedka gastric, iyo antacids afka kaas oo gacan ka geysanaya in laga takhaluso aashito.
Isdhexgalka Proton Pump Inhibitor
Kontoroolayaasha Bustayaasha (PPIs) ayaa ah kuwa ugu muhiimsan ee daaweynta qumanka iyo in ay ku jiraan wakiilada caan ah sida:
- Aciphex (rabeprazole)
- Nexium (esomeprazole)
- Ka hortagga (lansoprazole)
- Protonix (pantoprazole)
- Prilosec (omeprazole)
Dhamaan waxyaalaha korontada ku shaqeeya ee proton-ka ayaa lagu yaqaanaa in la yareeyo heerarka Reyataz (atazanavir), Edurant (rilpivirine), iyo Crixivan (indinavir).
Taas bedelkeeda, waxay kordhin karaan heerarka Isentress (raltegravir).
Intaa waxaa dheer, Prilosec waxay hoos u dhigi kartaa heerarka Viracept (nelfinavir), Intelence (etravirine), iyo Invirase (saquinavir).
Isdhexgalka H2 Blocker
Xinjirta 2aad (H2) maaha kuwo waxtar leh sida PPI laakiin waxaa laga yaabaa inay dadka qaar siiyaan gargaar ku filan. Fursadaha caanka ah waxaa kamid ah:
- Axid (nizatidine)
- Pepcid (famotidine)
- Tagamet (cimetidiin)
- Zantac (ranitidine)
Dhamaan xannibaadayaasha H2 waxaa lagu yaqaan heerka hoose ee Reyataz (atazanavir) iyo Edurant (rilpivirine). H2-blockers sidoo kale waxay kordhin karaan heerarka Isentress (raltegravir).
Tagamet, ayaa sidoo kale, hoos u dhigi kara heerarka Viramune (nevirapine) iyo suurtagal ahaanta Prezista (darunavir) iyadoo la kordhinayo heerarka Lexiva (fosamprenavir).
Sidoo kale, Zantac ayaa hoos u dhigi karta Prezista (fosamprenavir) iyo Kaletra (lopinavir / ritonavir).
Isdhexgalka Antacid
Antibiotika waxaa mararka qaarkood loo isticmaalaa PPIs si loo siiyo nasaarooyin dheeraad ah. Daawooyinka bukaanka laga soo iibsado waxaa badanaa lagu qaataa qaabka kiniiniga ee dareeraha ah ama la kariyo. Waxay noqon kartaa mid ama mid kalsiyum ku salaysan ama magnesium-ku salaysan oo ay ku jiraan:
- Maalox
- Mylanta
- Tums
- Rolaids
Dhamaan antacids waxay hoos u dhigi karaan heerarka Edurant (rilpivirine). Waxaa sidoo kale dhici karta inay hoos u dhigto heerarka Reyataz (atazanavir), Lexiva (fosamprenavir), iyo Aptivus (tipranavir).
Kiniiniyada Calcium sida Tums ayaa sidoo kale xoojin kara isdhexgalayaasha iyo in ay faragalinayaan sida ay u shaqeeyaan.
Iska ilaalinta isdhexgalka mukhadaraadka
Xaaladaha badankood, isdhexgalka ka dhexeeya mantarro iyo daawooyinka HIV-ga ayaa looga fogaan karaa iyada oo la kala soocayo qiyaasaha ugu yaraan afar saacadood. Xaaladaha qaarkood, qiyaasaha daaweynta ayaa laga yaabaa inay u baahan yihiin inay kala tagaan lix saacadood ama ka badan oo ku salaysan noocyada kale ee daroogooyinka aad qaadan karto.
Haddii aad qaadatid daawo wadnaha ah, ha noqoto mid laguu qoro, waa inaad u sheegtaa dhakhtarkaaga HIV-ga si aad u hesho tilmaamo cad oo ku salaysan isku-darka daawooyinka aad qaadato.
> Ilo:
> Lewis, J .; Stott, K.; Monnery, D. et al. "Iskaashatada daroogada iyo daaweynta daroogada ee Faroolojinikada ah iyo saameynta ay ku leeyihiin maareynta kiliinikada." Cudurka AIDS-ka ee STD. 2016; 27 (2): 105-9. DOI: 10.1177 / 0956462415574632.
> Thompson, T .; Lee, M .; Clarke, T. et al. "Ka hortagga calaamadaha caloosha oo ka dhexjirta bukaanada HIV-ga ee bukaan-socodka iyo xakamaynta dadweynaha." Ann Gastroenterol . 2012; 25 (3): 243-8.