Macluumaadka Muhiimka ah ee Daawooyinka Maahan
Stribild (oo sidoo kale loo yaqaan 'Quad pill') waa hal kiniin, daawo isku dhafan oo go'an oo ka kooban afar wakiil oo daawada antiretroviral ee loo isticmaalo daaweynta HIV:
- Tenofovir , nucleotide oo lakala qaado daawada transcriptase
- emtricitabine, nucleotide naqleotide celinta transcriptase celin labaad
- Elvitegravir , isdhexgaliye isdhexgalka
- cobicistat , xoojiye HIV
Stribild waxaa ansixiyay Maamulka Maraykanka ee Cuntada iyo Maandooriyaha (FDA) bishii Agoosto 2012 si loogu isticmaalo dadka waaweyn 18 iyo ka weyn ee bilaabaya daawooyinka dabiiciga ah markii ugu horeysay, ama kuwa ku jira daaweynta HIV ee si buuxda u xakameynaya (aan la garan karin) fayrasta fayraska .
Amniga iyo waxtarka xoogga leh ee Stribild ayaa lagu qiimeeyay 1,408 bukaanno qaan-gaar ah oo aan la daaweyn labadii siman ee laba-indhoole, taas oo go'aamisay in Stribild uu ahaa mid waxtar leh oo loo dulqaadan karo sida Atripla , daroogo kale oo xadidan oo qadarin ah oo ka kooban tobanofovir, emtricitabine, iyo efavirenz .
Sannadka 2016-ka, daroogada cusub ee daroogada loo yaqaan Genvoya ayaa shati u siiyey FDA, oo beddeshay tenofovir laakin daroogada cusub ee daroogada loo yaqaan Tenofovir alafenamide (TAF), oo loo yaqaano waxyeellooyin yar iyo daroogada hooseeya.
Dejinta
Stribild waa kiniin cagaaran, qallafsan, oo kiniin ah, oo ka kooban 150mg of elvitegravir, 150mg of cobicistat, 200mg of emtricitabine iyo 300mg of tenofovir. Waxaa ku xeeldheer "GSI" hal dhinac isla markaana leh "1" oo ku yaal hal dhinac oo kale.
Qiyaasta
Hal kiniin maalinle ah oo la qaato cunto. Stribild waa in aan lagu qaadin dawooyinka kale ee daawada antiretroviral ee loo isticmaalo daaweynta HIV.
Waxyaabaha kale ee saameynaya
Dhibaatooyin dhinaca daroogada ah ayaa lagu xusay bukaanada qaata Stribild. Dhacdooyinka ugu caansan, ee lagu soo warramey 7% ama bukaano badan, waxay ahaayeen:
- Lalabbo
- Shuban
- Madax xanuun
- Riyada aan caadi ahayn
Isdhexgalka Daroogada ama La'aanta
Xakamaynta waa in aan lagu qaadin daawooyinka soo socda ama dheeraadka ah:
- Daawooyinka ka hortagga migreebka: Cafergot, Migergot, Ergostat, Dhexdhexaadiye Ergotamiin, Wigren, Wigreles, Ergotrate, Methergine, DHE 45
- Daawada anti-psikotikada: Orap
- Daawooyinka xasaasiyadeed ee kolesteroolka: Zocor, Simcor, Vytorin, Mevacor, Advicor, Altoprev, Mevacor
- Dawada cagaarshowga B: Hepsera, Preveon
- Wakiilada Daawada: Daacad, Quicksolv Propulsid
- Daawooyinka Prostate: Uroxatral
- Daawooyinka dhiig-yari ee soodhoweyn: Revatio
- Dawooyinka anti-tuberculosis ku salaysan Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Sedatives: Calaamadaha, Halcion
- St. John Wort
Tixgelinno
Stribild waxaa laga yaabaa inay dhibaato ku tahay dadka qaba taariikhda dhibaatooyinka kelyaha. Fadlan kugula tali dhakhtarkaaga in aad qabtid arin noocaas ah ka hor inta aadan qaadan Stribild. Hawlgabka kelyaha waa in si joogto ah loogu baaro bukaanada ku jira Stribild. Jooji daaweynta bukaanada leh qiyaasta wax lagu qiyaaso ee ka hooseeya 50mL / daqiiqo. Dawooyinka nephrotoxic waa inaan marnaba loo gacan qaadin Stribild.
Labo ka mid ah maaddooyinka firfircoon ee Stribild (tenofovir, emtricitabine) ayaa sidoo kale firfircoon ka soo horjeeda cudurka hepatitis B (HBV) . Haddii aad qabtid HBV oo aad joojisid qaadashada Stribild, waxaad u baahan doontaa inaad kantaroosho asxaabta beerkaaga dhawr bilood sababtoo ah joojinta waxay marmarka qaarkood keeni kartaa HBV inuu ku faafo.
Sida kiiskoo dhan ee isku-dhafan ee isku-dhafan ee antiretroviral, NRTIs ee Stribild waxay la xiriiraan halis yar oo ah lactic acidosis, iyo sidoo kale dhibaatooyinka beerka.
Haddii aad la kulanto neefta oo gaaban; lallabbo iyo matag; xanuun ama calool xanuun aan la filayn; murqaha iyo daalka; tabardarnaanta gacmaha iyo lugaha; ama maqaarka maqaarka iyo / ama indhaha, isla markiiba wac dhakhtarkaaga. Cudurka lactic acid, gaar ahaan, wuxuu noqon karaa mid dilaa haddii aan la daaweyn.
Ilaha:
Maamulka Cuntada iyo Dawooyinka Mareykanka. "FDA waxay ansixisay kiniin cusub oo kiniin ah oo loogu talagalay daaweynta HIV ee bukaannada qaarkood." Silver Spring, Maryland; saxaafadeed la soo saaray 27-kii Agoosto, 2012.
Wohl, D .; Cohen, C .; Gallant, J .; et al. "Elvitegravir / cobicistat / emtricitabine / tenofovir DF (STB) ayaa leh wax-qabad joogto ah iyo kala duwanaansho la'aanta iyo dulqaad la'aanta muddada dheer efavirenz / emtricitabine / tenofovir DF (Week) 144 ee daaweynta-bukaanka HIV." Shirka 53aad ee Qayb-galka ah ee Aaladaha Antimicrobial iyo Chemotherapy (ICAAC). Denver, Colorado, Sebtembar 11, 1013; abstract H-672a.
Shalit, P .; Gallant, J .; Mills, A .; et al. "Cadaadiska muddada-dheer ee elvitegravir / cobicistat / emtricitabine / tenofovir DF marka la barbar dhigo efavirenz / emtricitabine / tenofovir DF ama ritonavir-kor u qaadaya atazanavir iyo emtricitabine / tenofovir DF ee maadooyinka lagu daaweeyo HIV-1. Shirka 53aad ee Qayb-galka ah ee Aaladaha Antimicrobial iyo Chemotherapy (ICAAC). Denver, Colorado; Sebtember 11, 2013; abstract H-671.