Isticmaalka, Tixgelinno, iyo Contraindications
Sustiva (efavirenz) waa daawo antiretrovoviral ah oo loo isticmaalo daaweynta HIV ee dadka waaweyn iyo carruurta.
Sustiva waxaa lagu qeexay sida non-nucleoside transcriptase inhibitor (NNRTI) sidoo kale waa qayb ka mid ah daawada loo isticmaalo daawada qiyaasta daawada loo yaqaan ' Atripla' (tenofovir + emtricitabine + efavirenz) oo badanaa loo isticmaalo daaweynta koowaad ee daweynta Maraykanka
Sustiva ayaa loo ansixiyay isticmaalka Maamulka Cuntada iyo Dawooyinka ee Maraykanka (FDA) 21-kii Sebtembar, 1998.
Yurub iyo qaybo kale oo adduunka ka mid ah, daroogada ayaa lagu suuq-gareeyay magac ganacsi oo kala duwan, Stocrin.
Nidaamka Daroogada
Sustiva waxaa laga helaa kaniiniga 600mg. Kiniiniga jaalaha ah, kiniiniga qafiifka ah waa filim duuban oo daabacan "SUSTIVA" oo labada dhinac ah.
Sustiva waxaa sidoo kale laga heli karaa 200mg iyo 50mg oo ah foomka kaabsarka. Kaabayaasha 200mg waa dahab dahab ah, waxaa lagu daabacay "SUSTIVA" oo ku jirta jidhka kaabsaar ah iyo "200 mg" oo ku yaal daboolka. Kaabayaasha 50mg waxay leeyihiin dabool dahab ah oo lagu daabacay "SUSTIVA" iyo jir cad oo lagu daabacay "t0 mg."
Sustiva waa inaan waligaa loo isticmaalin sida monotherapyka, lakiin halkii lagu daro daawooyinka kale ee daawada antiretroviral .
Isugeynta
Dadka qaangaarka ah, qaado hal kiniin ah 600mg maalintii, si caadi ah ka hor wakhtiga hurdada iyo calool madhan. Faa'iido ahaan:
- Haddii laysku daro rifampin (oo loo isticmaalo inta badan daaweynta qaaxada), kordhinta qiyaasta illaa 800mg maalinle ah oo loogu talagalay bukaannada miisaankoodu ka sarreeyo 110 rodol (50kg).
- Haddii ay la socoto voriconazole ( antifungal si joogto ah loo isticmaalo si loo daaweeyo caabuqyada fursadaha HIV ee la xidhiidha), kor u qaadista qiyaasta voriconazole 400 mg maalintii laba jeer maalintii oo hoos u dhig Sustiva ilaa 300mg maalin kasta.
Carruurta ugu yaraan saddex sano jir ah iyo in ka badan 7.7 rodol (35kg), u qor sida soo socota:
- 7.7 rodol (3.5kg) in ka yar 11 rodol (5kg): 100mg
- 11 rodol (5kg) in ka yar 16.5 rodol (7.5kg): 150mg
- 16.5 rodol (7.5kg) in ka yar 33 rodol (15kg): 200mg
- 33 rodol (15kg) ilaa in ka yar 44 rodol (20kg): 250mg
- 44 rodol (20kg) in ka yar 55 rodol (25kg): 300mg
- 55 rodol (25kg) ilaa in ka yar 71.6 rodol (32.5 kg): 350mg
- 71.6 rodol (32.5 kg) in ka yar 88lbs (40kg): 400mg
- 88 rodol (40kg) iyo in ka badan: 600mg
Cudurka sustiva waa la liqaa oo dhan ama rusheeyaa. Sustiva ee qaabka kiniinka, dhanka kale, waa inaan waligaa la jajabin, sababtoo ah taasi waxay sababi kartaa daaweyn aan ku filneyn (ama marba xad dhaaf ah) carruurta.
Saameynada Caadiga ah
Waxyeellooyinka ugu badan ee la xiriira isticmaalka Sustiva (10% kiisaska ama ka yar) waa:
- Finan
- Lalabbo
- Dawakhaad
- Madax xanuun
- Daal
- Insomnia
- Matagid
- Isku-dhafid la'aanta
- Calool xanuunka
- Riyooyin aan caadi ahayn, riyooyin cadcad
- Shuban
- Murugo
- Dareemid / walaac
Calaamadaha badankoodu guud ahaan waa kuwo gaaban, inta badan waxay is-xallinayaan dhowr toddobaad gudahood illaa bil. Qaar ka mid ah saameynta nidaamyada dhexe ee dareemayaasha (dawakhaad, diirad saarid) waxaa lagu yarayn karaa Sustiva ka hor wakhtiga jiifka.
Sustiva-Associated Rashes
Daraasad lagu sameeyay kiliinikada, 26% bukaanada dhawaan soo gaadhay Sustiva waxay dareemeen heerar qafiif ah maqaarka, inkastoo intooda badani ay ahaayeen mid sahlan oo dhexdhexaad ah oo badanaa badanaaba waxay u muuqdaan labadii toddobaad ee hore ee bilowga.
Haddii aad furo finan yar kadib markaad bilowdo Sustiva, la xiriir dhakhtarkaaga ama bixiyaha xanaanada caafimaadka. Xaalad dhif ah (in ka yar 1% kiisaska), firiiricu wuxuu noqon karaa mid aad u daran, oo keenaya xummad iyo xummad, taasoo muujinaysa jiritaanka jirka ee loo yaqaan 'Stevens-Johnson syndrome', kaas oo u baahan in la joojiyo oo keliya daaweynta laakiin daaweyn dhakhso ah dareenka.
Dhammaan kiisaska kale, finanku waxay inta badan xalinayaan iyagoo aan joojin daaweyn.
Khilaafaadka
Sustiva waa inaan waligeed loo isticmaalin daawooyinka kale ee non-nucleoside transcriptase: Edurant (rilpivirine), Intelence (etravirine), Rescriptor (delavirdine), ama Viramune (nevirapine).
Bukaanka qaba dareen-celin hore u-qaadis Sustiva-oo ay ku jirto cirbadda Stevens-Johnson ( eeg xagga sare ) ama qarxinta maqaarka sunta ah - waa in aan lagu soo celinin daroogada ama qandaraaska Atripla, oo ah qiyaas daawo oo isku dhafan oo ay ku jiraan Sustiva.
Sustiva sidoo kale laguma talineynin marka lagu daro daawooyinka cagaarshow C (HCV) Victrelis (boceprevir) iyo Olysio (simeprevir) sababtoo ah luminta saameynta daaweynta ee labadan antibiraal HCV.
Tixgelinta Daaweynta
Sustiva waxaa lala xiriiriyay cilladaha uur-ku-jirka ee dhowr nooc oo xayawaan ah. In kastoo ay weli jirto muran ka taagan in Sustiva ay halis dhab ah u leedahay bini-aadamka, waxaa lagu talinayaa in Sustiva laga fogaado inta lagu jiro uurka, gaar ahaan saddexda bilood ee ugu horeeya. Hooyooyinka ayaa sidoo kale lagula talinayaa in aysan naas nuujin markaad qaadaneyso Sustiva.
Ilaha:
Maamulka Cuntada iyo Dawooyinka Maraykanka (FDA). "Package Approval Pack - Sustiva (efavirenz) 50mg, 100mg, 200mg capsules." Silver Spring, Maryland; la soo saaray 21-kii Sebtembar, 1998.