Cilmi baadhayaashu waxay tilmaamaan cadaadis ay ku gaari karaan AIDS-ka muddo 3 sano ah
In kasta oo aysan jirin koorso loo diyaariyay qaabka HIV-gu u horumariyo hal qof illaa kan xigta, waxaa jira nooc (isbeddel) kuwaas oo la xiriira horumarka degdega ah. Kala duwanaanshahani wuxuu ka yimaadaa isbeddellada hidde-keena ee caadi ahaan horay u soo kordhay gobolka gudahiisa, marxalado kala duwan oo ka baxsan gobolkaas si ay u noqdaan kuwa ugu badan-haddii aysan aheyn kuwa culus.
Daraasad lagu daabacay wargeyska caafimaadka EBioMedicine ayaa soo warisay in mid ka mid ah noocyada noocan oo kale ah lagu go'doomay Cuba, taas oo loo yaqaanno horumarinta AIDS-ka muddo seddex sano gudaheed ah cudurka infekshanka-taas oo muran ka taagan cayayaanka ugu daran ee la ogaaday ilaa taariikhda.
Sida laga soo xigtay warbixinta, cilmi-baarayaasha ka socda jaamacada Leuven ee Belgium waxay si wanaagsan u aqoonsadeen culeyska sida CRF19 , oo ah kala-duwanaanshaha dib-u- eegidda ee HIV-ka oo ka kooban saddex nooc oo kala duwan , A, D, iyo G.
Halka HIV ay guud ahaan horumarinayso AIDS-ka muddo shan ilaa toban sano ah iyada oo aan la dawayn, CRF19 ayaa u muuqata mid si deg-deg ah u socota sidii qof loo gelin lahaa halis weyn oo ah jirro iyo dhimasho intaysan bilaabin daaweynta .
Natiijooyinka Barashada
Laba iyo laba bukaan ayaa lagu ogaadey cilmi-baarayaasha inay yihiin horumarin degdeg ah (RP), taasoo muujinaysa hoos u dhac ku yimid tiradooda CD4 illaa 200 oo unug / mL ama soo bandhigay xaalad cudurka AIDS-ka ah (ama labadaba).
Da'da dhexdhexaadka ah ee bukaanka ayaa ahaa 34, halka celceliska tirada CD4 ee waqtiga cudurka lagu ogaaday 276 unug / mL. Taas bedelkeeda, isugeyn la isugu keenay bukaannada HIV iyada oo aan kala duwanayn CRF19 waxay celcelis ahaan celcelis ahaan CD4 u dhaxeysaa 522 iyo 577 waqtiga cudurka.
Intaa waxaa dheer, horumariyeyaasha degdega ah waxay qabeen fayras HIV-ga ah hal-ilaa seddex laab ka sarreeya horumarka aan degdegga ahayn.
Natiijada, dadka bukaanka ah ee la xaqiijiyay CRF19 waxay leeyihiin wakhtiyo dhexdhexaad ah oo u dhexeeya seroconversion iyo AIDS oo keliya 1.4 sano marka la barbar dhigo 9.8 sanadood oo ah kuwa aan ka tirsanayn CRF19.
Faahfaahinta Horumarka degdegga ah
Cilmi baadhayaashu waxay awoodeen inay ka saaraan dhowr arrimood kuwaas oo laga yaabo inay sharaxaad ka bixiyaan horumarka degdegga ah ee AIDS-ka. Marka la eego tirakoobyada, waxaa jiray horumarin fara badan oo heterosexual ah oo ka sii korodhsan kuwa aan wax-qabad lahayn (49% vs28%). Intaa waxaa dheer, wax khilaaf ah oo ku saabsan helitaanka HIV - da ee dhaqdhaqaaqa jinsiga (anal, midig).
Iyadoo ku saleysan natiijooyinkooda, baarayaashu waxay aamminsan yihiin in isbeddel degdeg ah oo ku yimaada qaabka CRF19 ay sharaxi karaan dhacdooyinka.
Guud ahaan, waxaa jira laba nooc oo isku-qaboojiye ah oo ku yaalla dusha sare ee unugyada dhiigga cad ee u oggolaanaya galitaanka HIV in ay galaan unug: CCR5 iyo CXCR4 . CCR5 waa wada-wada-qaadaha in HIV-gu guud ahaan isticmaalo caabuqa xilliga hore, halka CXCR4 uu yahay mid loo isticmaalo infekshanka dambe.
Iyada oo qaababka kala duwan ee CRF19, fayrasku wuxuu ka wareegayaa isticmaalka CCR5 ilaa CXCR4 si ka dhakhso badan sida noocyada kale ee HIV . Marka sidaas la samaynayo, horumarka cudurka ayaa sidoo kale la xawaarayaa, taasoo horseedi karta horumarinta hormarinta AIDS-ka.
Natiijooyinkaas waxay u badan tahay inay dalbanayaan kor u kaca kormeerka HIV ee Cuba, oo hadda jira heer ah boqolkiiba 0.2% (marka la barbar dhigo 0.9% gudaha Maraykanka) iyo in ka badan lix kun oo kiis la xaqiijiyey.
Muxuu yahay, marka la eego celceliska waqtiga caabuqa illaa baaritaanka illaa laga bilaabo 37 bilood illaa 55 bilood, masuuliyiinta caafimaadka dadweynaha ma awoodi karaan inay aqoonsadaan shakhsiyaadka leh kala duwanaansho CRF19 si deg deg ah si ay u xakameeyaan fiditaanka degdegga ah ee fayraska.
In kasta oo qaylo-dhaannada caafimaad ee dadweynaha hadda la kiciyey, haddana kala-duwanaanshaha Cuba waxa laga soo celiyay 2005 illaa iyo laga yaabo inay ka soo jeedaan Bartamaha Afrika, halkaas oo kiisaska laga soo sheegey Angola, Burkina Faso, Cameroon, iyo Togo.
Ilaha:
Khouri, V .; Khouri, R .; Alemán, Y .; et al. "CRF19_cpx waa habka Evolutionary ee ku habboon HIV-1 Variant oo si xariif ah ula xiriirta horumarka degdegga ah ee AIDS-ka ee Cuba." EBioMedicine. Janaayo 28, 2015; doi: 10.1016 / j.ebiom.2015.01.015.
Casado, G .; Thomson, M .; Sierra, M .; et al. "Aqoonsiga Cudurka HIV-1 ee ku dhex jira ADG Foomka Dib-u-Celinta Qalabaynta (CRF19_cpx) ee Cuba." Maqaalka Caadooyinka Immune Deficiency Immunities (JAMA). Disembar 15, 2005; 40 (5): 532-537.
Garrido, C .; Zahonero, N .; Fernandés, D .; et al. "Tilmaamaha isbeddelka, jawaab celinta virological iyo adkaysiga daroogada ayaa lagu qiimeeyay dhibco dhiig ah oo laga helay bukaannada HIV oo ku yaal daweynta antiretroviral ee Angola." Daabacaadda kiimiko ee Antimicrobial. Janaayo 24, 2008; 61 (3): 694-498.
Tebit, D .; Ganame, J .; Sathiandee, K .; et al. "Kala duwanaanshaha HIV ee ku nool Dhulka Burkina Faso." JAMA. Oktoobar 1, 2006; 43 (2): 144-152.
Machuca, A .; Tang, S .; Shixing, D .; et al. "Kordhinta Kala duwanaanta Cudurrada iyo Dib-u-soo-nooleyaasha Dib-u-Celinta ee HIV-1 ee ku-deeqaha Dhiigga laga bilaabo Magaalada Cameroon." JAMA. Julaay1, 2007; 45 (3): 361-363.
Yaotsè, D .; Nicole, V; Fabien Roche, N .; et al. "Tilmaamaha hiddaha ee cudurrada HIV-1 ee Togo waxa ay muujinayaan murugo sarreeya iyo isku-dhafanaanta is-difaacida daawooyinka ee dadka bukaanka ah ee ARV." Cudurada, Genetics iyo Evolution. Luulyo 2009; 9 (4): 646-652.