Cudurka bakteeriyada ee sambabada ee sambabada leh Cudurka Faybriska
Waxaa laga yaabaa inaad ka maqashay gumeysiga bakteeriyada haddii aad ku nooshahay fayruuska cysticis. Maxay tani micnaheedu tahay?
Waa maxay Colonization?
Colonization waxay dhacdaa marka jeermiska uu ku noolaado ama uu ku noolaado hudheelka martida ah, laakiin ha ku soo dhex galin unugyada ama dhaawici. Colonization waxaa loola jeedaa jiritaanka jeermiska oo keeni kara jeermis, laakiin ma aha in jeermiska laftiisa.
Haysashada maadooyinkaas oo kale, hase yeeshee, waxay kordhisaa khatarta caabuqa haddii jawiga saxda ah ee cudurka uu dhaco.
Muhiimadda Colonization ee Cudurka Faybriska
Dadka qaba cystic fibrosis (CF) ayaa badanaa lagu xiraa bakteeriya, gaar ahaan xiiqda iyo hawo-mareenada. Haddii uu nooluhu bilaabo inuu soo galo unugyada oo uu waxyeelo u geysto ama uu qofka bukaa u xanuunsado, gumeysigu wuxuu noqonayaa caabuq.
Isbedelka Xaaladaha Neefsashada ee Dadka Dadka qaba Faybriska 'Cystic Fibrosis'
Dadka qaba cystic fibroxis, dheecaanka xad-dhaafka ah ee dheecaanka iyo bakteeriyada daba-galka ah waxay keenaysaa nooc gaar ah oo ah xanuun khatar ah oo joogta ah. Dadka qaba cystic fibroxis ayaa ugu dambeyntii ku dhacaan cudurka bronchiectasis kaas oo marinnada hawadu ay noqoto mid waxyeello u gaysata oo jabtay.
Bronchiectasis waa xaalad taas oo ay la socdaan buruqyada iyo bronchioles (laamaha yar ee hawo-mareenka) in ay sii dhumuc noqdaan, la ballaariyo oo la gooyo. Mucus wuxuu ku ururaa hawo-mareenada la ballaariyay ee loo yaqaan 'inflamed'.
Infekshanku markaa kadib wuxuu keenayaa sii dheereyn, xoojin, iyo naqshadeynta hawo-mareenada oo soo noqnoqonaya marxalado qallafsan.
Marka laga soo tago borotiinka iyo boroniyoolojiyadu waxay yiraahdaan alveoli , qoryaha hawada ee yaryar iyadoo loo marayo isbeddelka oksijiinka iyo kaarboon dioxide. Marka bararroorkiyadu u horseedi karaan kuwan ugu yar ee hawo-mareenada, waxay luminayaan dib-u-soo-ceshadaynta (dhumucdheerka iyo caarada) oo lagu xakameeyo xab-ka, oxygen-na lagu neefsado sanbabada ma gaari karo alveoli-gaas-gaas-gaaskan si ay u dhacdo.
Maxay Sababaha Sanku ugu Soogoobaan Dadka qaba Faybriska 'Cystic Fibrosis' Wax Bixiya Mucus?
Waa wax aan la hubin in dadka qaba fibro-biska cysticisku ay marka hore soo saaraan xab xannibaad dheeri ah ama ay sidaas sameeyaan sababtoo ah gumeysiga bakteeriyada. Si kastaba ha ahaatee, baaritaanka sanbabada ee dhalaanka cusub ee qaba fibro-biska cysticis kuwaas oo aan wali lagu xirin bakteeriyadu waxay muujinaysaa wax soo saarka xad-dhaaf ah. Natiijooyinkani waxay soo jeedinayaan in xabsigu uu saadaaliyo dadka qaba cystic fibrosis si ay u qaboojiyaan bakteeriyada.
Waa Maxay Noocyada Bakteeriyadu isku dhejiyaan sambabada dadka qaba Cudurka Faybriska?
Noocyo badan oo bakteeriya ah (bakteeriyadu waxay ku koraan joogitaanka oksijiin), bakteeriyadu waxay ku koraan hawo la'aan (oxygen) iyo cudurrada fursadaha sida fungus waxay xoojiyaan sambabada dadka qaba cystic fibrosis. Ereyga loo yaqaan 'pathogens pathogens' waxaa loo isticmaalaa in lagu qeexo maadooyinka jirka ee aan si caadi ah u keenin infakshanka dadka caafimaadka qaba, laakiin waxay keeni karaan infakshan marka "fursada" soo baxdo, sida marka cudurka sambabku uu joogo.
Halkan waxaa ku yaala qaar ka mid ah haybadaha ku xeeldheer sanbabada dadka qaba cystic fibrosis:
- Pseudomonas aeruginosa
- Staphylococcus aureus (oo ay ku jiraan MRSA )
- Escherichia coli
- Haemophilus influenzae
- Klebsiella
- Ka hortag
- Propionibacterium
- Veillonella
- Aspergillus (wax ka ogow aspergillosis bronchopulmon ee dadka qaba cystic fibrosis)
Noocyada ugu Badan Ba'an ee Pathogens ee Doonaya Airways Airways ee Dadka qaba CF
Qeybaha kor ku xusan, colonization Pseudomonas sida caadiga ah waxay ku badan yihiin qiyaastii boqolkiiba 80 dadka qaangaarka ah ee leh fibro-biska cysticis waxaa lagu xiraa nooca bakteeriyada.
Noocyada Badbaadada ah ee Badbaadada ah iyo Cudurka Fibrosis
Marka laga soo tago cudurada kor ku xusan, dadka qaba cystic fibrosis waxay u badan tahay in lagu xiro "superbugs" ama waxqabadyo badan oo iskudhaf ah . Noocyo badan oo ka mid ah antibiyootikada (kiimikooyinka u adkeysanaya antibiyootiko badan) waxay qabtaan sanbabada qofka qaba fibro-biska cysticis wuxuu qaataa daawada antibiyootigga ee caabuqyada sanbabada, sida Pseudomonas.
Colonization iyo infekshin leh xoolo-dhaqameedyo badan oo adkaysi leh ayaa ah kuwo cabsi leh maxaa yeelay asxaabyadani waxay iska caabinayaan daaweynta antibiyootigga caadiga ah.
Waa maxay sababta Colonization iyada oo Pseudomonas ku Xaji Karaan?
Khabiiro badani waxay leeyihiin feker ama fariimo badan oo ku saabsan sababta sambabada dadka qaba cystic fibrosis waxaa badanaa lagu xannibay Pseudomonas, oo ay ku jiraan kuwa soo socda:
- Nadiifinta dhadhanka oo la yareeyey iyada oo ay weheliso cilladaha peptides bakteeriyada
- Difaaca jirka ee sambabada sababtoo ah heerarka hooseeya ee glutathione iyo oksaydhiyada yar yar
- Hoosudhaca bakteeriyada by unugyada sanbabada
- Tirada tirada bakteeriyada ee sii kordheysa
Ma garanayno sida dhabta ah ee farsamooyinkani ay ugu muhiimsan yihiin dejinta gumeysiga Pseudomonas. Si kastaba ha noqotee, waxay u muuqataa in markii Pseudomonas ay qabato, infekshanka joogtada ahi sii socdo.
Dadka qaba cystic fibrosis kuwaas oo lagu xannibay Pseudomonas waxay u baahan yihiin daaweynta dayactirka maalin kasta iyo sidoo kale daweyn joogto ah oo daaweynta antibiyootigga gardarrada ah marka infekshanku ku dhaco. Nasiib daro, xitaa daaweyn noocaas ah, infekshanka Pseudomonas wuxuu keenaa luminta luminta hawsha sanbabada wuxuuna keenaa dhimashada ugu dambaysa ee dadka badankood oo leh cystic fibrosis. Baro wax badan oo ku saabsan Pseudomonas ee dadka qaba cystic fibrosis .)
Ilaha
Boutin, S., iyo A. Dalpke. Qaadashada iyo Qalitaanka Hawo-mareenka Microbiotia ee Nolosha Hore ee Bukaan-jiifka Fibrosis. Qalabka Cilmi-nafsiga iyo Jilayaasha . 2017. 4 (1): 1.
Huang, Y., iyo J. LiPuma. Microbiome ee Cystic Fibrosis. Kiniiniga Caabuqa Caafimaadka . 2016. 37 (1): 59-67.
Voynow JA, Mascarenhas M, Kelly A, Scanlin TF. Cystic Fibrosis In: Grippi MA, Elias JA, Fishman JA, Kotloff RM, Pack AI, Senior RM, Siegel MD. eds. Fishman Cudurrada Cudurrada iyo Cudurrada, Fish Edition . New York, NY: McGraw-Hill; 2015.