Hormones, Himilada Maskaxda, Hurdada
Nimanku waxay qiyaastii boqolkiiba 10 ka mid ah kuwa laga helay fibromyalgia, cilmi-baaristuna waxay muujinaysaa in ay calaamado ka duwan yihiin dumarka. Laakiin sababta?
Jawaabtu waxay ku dhici kartaa riyadu. Hormarisyada labka ah waxay ciyaaraan door weyn oo la yaab leh oo ku saabsan khibrada xanuunka, iyo kala duwanaanta kiimikada maskaxda iyo hurdada ayaa ku dhici karta, sidoo kale.
Kala duwanaanta Hormonal
Farqiga ugu caansan ee udhexeeya fibromyalgia ee raga iyo dumarka waa hormoon.
Dumarka, cirbadaha badanaa waxay ku xidhan yihiin wareegga caadada , iyo dhacdooyinka hormoonada sida menopause ama hargabku waxay dhalin karaan calaamadaha.
Dhab ahaan, raggu ma qabaan dhacdooyin hormoon oo muuqda. Ilaa iminka, daraasadaha baaraya hormoonada hormoonada haweenka ama cilladaha aan caadiga ahayn ee fibromyalgia ayaa si fudud loo qaban, sidaa darteed ma garanayno doorka, hadii ay jiraan, hormoonnadaas ciyaaraan. Guud ahaan, waxaan haynaa caddayn in hormoonnada labka ah ay saameyn ku yeelato xanuunka.
Testosterone, hormoonka asaasiga ah ee labka ah, ayaa loo maleynayaa inuu ciyaaro door muhiim ah marka ay timaado xanuunka guud ahaan. Cilmi baaris ayaa soo jeedineysa in ay ka caawin karto ka hortagga daalka muruqyada iyo, iyadoo la socota borotiin gaar ah, ayaa laga yaabaa inay ka caawiso muruqyada muruqyada kadib jimicsiga. Hoormoonka labka ah wuxuu sidoo kale saameyn karaa hababka kale ee bayoolojiga ee la xariira daal iyo xanuun.
Waxaan sidoo kale ognahay kala duwanaanta ku saleysan jinsiga ee cortisol hormoonka cadaadiska, taas oo cilmi-baaristu muujinayso inay hoos u dhacdo fibromyalgia.
Mid ka mid ah daraasad lagu daabacay cilmi-nafsiga caafimaadka 2008 ayaa muujisay in heerarka cortisol ay ka duwan yihiin haweenka guurka ah ee guursaday marka loo barbardhigo kuwa aan is-qabin ee xaasleyda ah iyada oo ragga aysan soo bandhigin khilaafaad ku salaysan farxad guur. Cilmi-baadhayaashu waxay ku qiyaaseen in tani ay sharaxi karto sababta ay u saameysay xaaladaha ku jira cortisol ee ay u badan tahay haweenka.
Chemistry Maskaxda
Maskaxda ragga iyo dumarku isku mid maahan. Hal farqi oo saameyn ku yeelan kara waxa fibromyalgia u eg yahay jinsi kasta waa neurotransmitter (warge kiimiko) serotonin .
Serotonin waxaa la rumeysan yahay in uu door muhiim ah ka ciyaaro fibromyalgia. Meelaha ay saameyn ku leedahay waxaa ka mid ah xanuun, hurdo, welwel, iyo niyadjab. Qaar ka mid ah cilmi-baadhistu waxay soo jeedinaysaa in nidaamka serotoninku si ka duwan u shaqeeyo ragga marka loo eego haweenka.
Daraasad cilmi baaris 2008 ah oo lagu daabacay Neuroimage ayaa muujisay in ragga ay yaryihiin serotonin reseptors (unugyada maskaxda ee ka jawaab celiya) ka badan dumarka. Si kastaba ha noqotee, habka dib-u- helidda- oo ah "dhab ahaan" dib-u-warshadaynta "sidaas darteed neurotransmitter-ka mar kale ayaa loo isticmaali karaa-wuxuu noqon karaa mid wax ku ool ah ragga.
Daroogooyinka gaabis ah ee loo yaqaan 'reuptake' ayaa inta badan loo qoraa fibromyalgia. Waxaa loo yaqaan 'SSRIs' ( serifonin resorttake inhibitors) ama SNRIs (daawada serotonin-norepinephrine inhibitors) Laba ka mid ah saddexda daroogo ee loo aqoonsaday xaaladdan waa SNRIs: Cymbalta (duloxetine) iyo Savella (milnacipran) .
Sababtoo ah kala duwanaanshaha jinsiga ee nidaamka serotonin, dhakhaatiirta qaar ayaa soo jeediyay in daawooyinkan lagu tijaabiyo ragga iyo dumarka si gaar ah. Tani weli ma dhicin, laakiin waxaan haynaa caddayn muujin ah in ragga iyo dumarku ay si kala duwan uga jawaabaan fasalka dawadan.
Daraasad gooni ah oo lagu daabacay Baadhista Cilmi - nafsiga ee 2007 ayaa muujisay in hoos u dhaca heerarka serotonin-ka ee jidhku aanu saameyn ku yeelanaynin raga iyo haweenka si la mid ah. Dumarka, waxay sababtay dabeecad xumo iyo dabeecado taxadar leh. Ragga ma lahayn isbeddello niyad-jabi ah, laakiin waxay noqdeen wax aan fiicnayn, ayay cilmi-baarayaashu sheegeen.
Noocyada noocyada kala duwan, oo aan si buuxda u fahmin, waxay ka dhigi kartaa fibromyalgia inay adkeeyaan dhakhtarrada caadaystay inay arkaan dhibaatooyinka niyadda ee haweenka fibromyalgia ee haweenka.
Miyuu Hurdada Muhiim u Yahay Ragga?
Daraasad la daabacay 2012-ka ee Psicothema waxay eegtay farqiga jinsiga ee calaamadaha fibromyalgia, oo ay ku jiraan xanuun, hurdo, daal, jirro maskaxeed, murugo shucuur, iyo shaqo.
Cilmi-baadhayaashu waxay ogaadeen in tayada hurdada ay tahay midka ugu qiimaha badan ee ragga, laakiin aaney haween ahayn.
Fibromyalgia waxaa loo yaqaanaa in lagu daro isdhexaadinta hurdada iyo inta badan isku laabo hal ama in ka badan oo ah hurdada hurdo la'aanta iyadoo lala socdo hurdo la'aan . Baaritaankani wuxuu soo jeedinayaa in aqoonsashada iyo daaweynta dhibaatooyinka hurdada ay muhiim u yihiin ragga.
Fahmidda Farqiga
Illaa iyo hadda, ma hayno macluumaad ku filan si aan si buuxda u fahanno kala duwanaanshaha khibradda maleegidda dumarka iyo fibromyalgia. Markaan wax badan ka ogaanno, labadaba xaaladdan iyo kala duwanaanta jinsiga, guud ahaan, wax badan ayaan ku baranaynaa.
Intaas ka dib, waxaa muhiim ah in kor loo qaado wacyiga ah in ragga ay awoodaan oo ay helaan fibromyalgia.
> Ilo:
Wuxuu gubaa LA, et. al. Somali Journal of Physiology. Rugta muruqyada oo kor u kaca ayaa ku dhaca labka wiil ee aan ahayn haweeney ASIC3 - / - jiirarka.
Jovanovic H, et. al. NeuroImage. 2008 Feb 1; 39 (3): 1408-19. Farqiga galmada ee serotonin 1A ee daaweeye iyo serotonin ee ku xiran maskaxda bini'aadamka oo lagu cabbiray PET.
Saxbe DE, Repetti RL, Nishina A. cilmi nafsiga caafimaadka. 2008 Jan: 27 (1): 15-25. Ku qanacsanaanta guurka, ka soo kabashada shaqada, iyo cortisol-ka caanka ah ee ragga iyo dumarka.
Walderhaug E, et. al. Cilmi-nafsiga 2007 Sep 15; 62 (6): 593-9. Dhibaatooyinka isdhexgalka ee galmada iyo 5-HTTLPR oo ku saabsan niyadda iyo dareen-xumada inta lagu jiro quudinta cirridka ee dadka caafimaadka qaba.