Melatonin iyo Sida Loo Helo Dhibaatooyinka Hurdada iyo Labbiska ee Alzheimers
Cudurka Alzheimer waa xanuun aad u daran, laakiin daaweynta gaarka ah sida hormoonka melatonin ayaa laga yaabaa inuu awoodo inuu hagaajiyo astaamaha adag sida hurdo la'aanta iyo sunta.
Alzheimers iyo Melatonin
Melatonin wuxuu leeyahay kaalmo badan oo jidhka ka mid ah, laakiin waxaa si gaar ah muhiim ugu ah hannaanka hurdada. Melatonin waxaa lagu soo saaraa maskaxda iyagoo qanjirada cirridka leh. Qanjirkaas ayaa sii deynaya heerkiisa ugu sarreeya ee Melatonin-ka subaxdii, hormoonka wuxuu u muuqdaa inuu yahay qalab wax ku ool ah oo isbeddel ah oo aan ugu yeereyno hurdo.
Cilmi baaris ayaa muddo dheer samaysay in heerarka melatonin ay si dabiici ah u yaraadaan da'da, laakiin dadka qaba cudurka Alzheimers ayaa leh heerar hooseeya - mararka qaarkoodna kala badh in ka badan inta dadka da'da ah ee aan lahayn cudurka. Sidoo kale, dhibaatooyinka hurdadu badanaa waa calaamad muujinaysa Alzheimers. Sannadihii ugu danbeeyay, tiro daraasado ah ayaa sheegay in faa'iidooyinka melatonin dheeri ah, maaha oo keliya in la yareeyo dhibaatooyinka hurdada ee Alzheimer-ha, laakiin sidoo kale waxaa sidoo kale la filayaa in ay dhacdo.
Soodhaha ayaa loola jeedaa khalkhalka akhlaaqda ee caan ku ah cudurka Alzheimers oo u muuqda in ay dhacaan fiidkii hore. Sababaha aan si buuxda u cadeyn, dadka badan ee Alzheimers soo bandhigay waxay sii kordheen jahwareerka , walwalka , kacdoonka iyo xitaa gardarrada dhammaadka maalinta. Sida laga soo xigtay ururka Alzheimer's Association, ku dhowaad shan meelood oo ka mid ah dadka qaba cudurka Alzheimers ayaa la kulmi doona caadada qatarta ah, badanaa marxaladaha dhexe ee cudurka.
Salaaku waxay qaadataa wax khasaare ah oo ku dhacda kuwa leh Alzheimers iyo si weyn u kordhiya diiqadda iyo daalka. Nasiib wanaag, waxaa jira caddayn ah in melatonin ka caawin karto daminta iyo dhibaatooyinka hurdada ee la xiriira.
Faa'iidooyinka kale ee Melatonin ee Alzheimer's
Melatonin ayaa sidoo kale leh faa'iidooyin kale. Waa antioxidant xoog leh, oo loola jeedo wax ka qabashada fal-celinta kiimikada ee waxyeellada u keeni karta unugyada.
Waxay u muuqataa in ay leedahay sifooyin gaar ah oo neuroprotective, taasoo macnaheedu yahay in ay ka caawiso ilaalinta unugyada iyo unugyada maskaxda waxyeello. Waxaa sidoo kale jira caddayn muujinaysa in maqnaanshaha melatonin uu kaalin ka ciyaarayo niyad-jabka.
Daraasadaha qaarkood waxay soo jeedinayaan in hoormoonka uu hagaajin karo naafonimada khafiifka ah , inkasta oo cilmi-baarayaashu ay xooga saarayaan in saameyntu ay xadidan tahay iyo in melatonin uusan ahayn "daawo" cudurka Alzheimers oo buuxa. Qaar ka mid ah cilmi-baarayaasha ayaa ka digay in saameynta hormoonka uu noqon doono mid aad u yar marka dambe ee Alzheimer's .
Cilmi-baadhayaashu waxay bilaabeen inay kobcaan "melatoninergic" ama daawooyinka melatonin-ka ah oo muddo dheer shaqeynaya oo leh bartilmaameedyo gaar ah. Tusaale ahaan, Rozerem (ramelteon) wuxuu ku guulaystay FDA ogolaanshaha muddada-dheer ee xanuunka hurdada. Laakiin illaa iyo hadda, dawooyinka melatonin-nooca ah looma diyaarin gaar ahaan cudurka Alzheimer ama caato.
Khadka hoose
Daraasado cilmi-baaris oo dheeri ah ayaa loo baahan yahay in la qabto marka la isticmaalayo isticmaalka melatonin ee cudurka Alzheimer si uu dhab ahaantii u fahmo faa'iidada dhabta ah (ama aan).
Laakiin maaddaama melatonin lagu sifeeyo kaalmo dheeraad ah, waxaa la heli karaa iyadoon warqad dhakhtar qorin. Marka la sheego, ka hor inta aanad hormoonka u dhiibin qof qaba Alzheimers, waa inaad la tashataa dhakhtarkiisa, kuwaas oo awoodi doona inay go'aamiyaan inay macno samaynayso.
Ilaha:
Ururka Alzheimers. "Hurdada Isgaadhsiinta iyo Labbiska
Cardinali, DP "Melatonin. Vertex, 2007 Jul-Aug; 18 (74): 288-93.
Cardinali, DP, Furio, AM, & Brusco, LI Qaybaha caafimaadka ee ka hortagga melatonin ee cudurka Alzheimers. Curr Norrofarmacol . 2010 Sep; 8 (3): 218-27.
Cardinali, DP, Furio, AM, & Reyes, MP "Muujiyo caafimaad oo loogu talagalay isticmaalka melatonin sida wakiilka chronobiotic iyo cytoprotective." Ann NY Acad Sci , 2005 Dec; 1057: 327-36.
Cardinali, DP, & Furio AM, & Reyes MP, & Brusco LI "Isticmaalida cinwaanada" chronobiotics "oo ku saabsan wareegga hurdada ee hurdada jiifka. Kansarka wuxuu sababaa kantarool, 2006 May; 17 (4): 601-9
Furio, AM, Brusco, LI, & Cardinali, DP "Qalabka daaweynta ee macquulka ah ee melatonin ee ku yaraanta liidashada garaadka: Daraasad dib u eegis ah." J Pineal Res., 2007 Nof; 43 (4): 404-9.
Pandi-Perumal, SR, Srinivasan, V., Poeggeler, B Hardeland, R., & Cardinali, DP "Fahmida Maandooriyaha: isticmaalka dhego-xatooyo melatonergic ah si loogu daaweeyo hurdo-abuurka diiradda saaraya ramelteon." Natiijada Hawlgabka Caafimaadka ee Neurol 2007 Apr; 3 (4): 221-8.
Sanchez-Barcelo, EJ, et al. "Melatonin iyo dawooyinka melatoninergeri sida wakaaladaha daweynta: Ramelteon iyo Agomelatine, labaduba waa kuwa ugu roon ee daaweynta melatonin." Patent-ka ugu dambeeyay ee Onocrine, Metabolic & Immune Discovery Discovery . 1: 2 (2007): 142-51.
Srinivasan V, Pandi-Perumal SR, Cardinal DPi, Poeggeler B & Hardeland R. Melatonin oo ku jira cudurka Alzheimer iyo xanuunka 'perturbing' neurodegenerative. Behav iyo Funen Funen. 2006 Maajo 4: 2: 15.
Wu. YH & Swaab. DF "Dhibaato iyo xeelado loogu talagalay dib-u-habeynta nidaamka rikoodhada wareegga wareega ee gabowga iyo cudurka Alzheimers." Daawada Hurdada. 2007 Sep; 8 (6): 623-36. Epub 2007 Mar 26.
Diidmada: Macluumaadka ku yaala boggan waa ujeedo waxbarasho kaliya. Waa inaan loo isticmaalin beddelka daryeelka shakhsi ahaaneed ee dhakhtar shati leh. Fadlan u tag dhakhtarkaaga si loo ogaado iyo daaweynta wixii astaamo ah ama xaaladda caafimaad .