Lagu Ogolaaday Isticmaalka Dadka qaba Cudurka Dabaysha Xanuunka 3 Cagaarshow Cagaarshow
Daklinza (daclatasvir) waa daroogada loo isticmaalo daaweynta isku dhafan ee daaweynta cagaarshow C (HCV) ee dadka qaangaarka ah 18 sano ama ka weyn. Daklinza waxay ka shaqeysaa xayiraad la yiraahdo protein la yiraahdo NS5B (protein aan lahayn qaab-dhismeedka 5B) in HCV ay u isticmaasho si ay uqorayso RNA-ga, si wax ku ool ah marxaladda wareegga nolosha 'wareegga nolosha'.
Daklinza waxaa la ansixiyay July 24, 2015, Maamulka Mareykanka ee Cunnada iyo Maandooriyaha ee loogu talagalay bukaannada qaba infakshanka HCV ee ba'an ee joogtada ah, oo ay ku jiraan kuwa qaba cirrhosis.
Daklinza waxaa loo isticmaali karaa bukaanka hore ee aan la daaweynin (daawayn-naeef), iyo sidoo kale bukaanno hore loo daweeyey (daawayn-khibrad leh) kuwaas oo qayb ahaan ama wax jawaab ah u lahayn daaweynta HCV kahor.
Cilmi-baaris cilmi-baaris ayaa muujisay in heerka daaweynta bukaanka daaweyn-naeef loogu daaweyn karo daaweynta Daklinza kudhisan 98%, halka heerka daaweynta bukaan-socodka daaweynta qaba cirrhosis uu yahay 58%.
Miisaanka lagu taliyey
Mid ka mid ah 60 mg oo kiniin ah oo maalin walba la qaato ama aan lahayn cunto ah Sovaldi (sofosbuvir) . Muddada lagu talinayo daaweynta waa 12 toddobaad.
Qiyaasta daawada waxay u baahan tahay in lagu hagaajiyo bukaanada qaadata daawada CYP3A ama indhaha CYP3A ( fiiri liistada hoose ). Ku guuldareysiga in la sameeyo waxay yareyn kartaa saameynta daweynta ee Daklinza, iyo sidoo kale kordhinta suurtagalnimada daaweynta adkaynta. Xaaladahaas oo kale, waxaa lagu talinayaa in qiyaasta loo yareeyo 30 mg maalintii mar iyada oo xoog leh CYP3A inhibitor ah oo kordhay 90 mg maalintii maalin kasta oo leh cufur xooggan oo CYP3A ah.
Daklinza waxaa loogu talagalay isticmaalka daaweynta isku dhafan ee Sovaldi waana in aan marnaba loo isticmaalin sidii monotherapy.
Nidaamyada
Daklinza waxaa laga helaa 30 mg iyo 60 mg foomka kiniinka ee afka.
Kiniiniyada 30 mg waa cagaar iyo fentifal ah oo qaabeysan, oo leh "BMS" oo ka kooban hal dhinac iyo "213" dhinaca kale. Kiniinada 60 mg ayaa sidoo kale ah qaab cagaaran iyo feexan qaab muuqaal ah, iyada oo "BMS" ay ka kooban yihiin hal dhinac iyo "215" dhinaca kale.
Saameynada Caadiga ah
Waxyeellooyinka ugu badan ee la xidhiidha isticmaalka Daklinza / Sovaldi ee isku-darka daaweynta (oo ku dhacda in ka badan 5% bukaannada) waa:
- Daal
- Madax xanuun
- Lalabbo
- Shuban
Isdhexgalka daroogada
Qiyaasta Daklinza waa in la yareeyaa 30 mg marka la qaato ka-hortagga ka-hortagga CYP3A:
- Antibiyootiko: cadithromycin, telithromycin
- Daawooyinka anti-fungal: itraconazole, ketoconazole, posaconazole, voriconazole, telithromycin
- Cudurrada HIV-ga: Crixivan (indinavir), Invirase (saquinavir), Viracept (nelfinavir), Norvir-baakteey Reyataz (atazanavir)
Qiyaasta Daklinza waa in la kordhiyaa illaa 90 mg marka la qaato soo socda indhaha dadka CYP3A:
- Daawada qotodheerta: Taabacayaasha
- Daawada kortikosteroid: dexamethasone
- Cudurrada HIV-ga: Sustiva (efavirenz), Intelence (etravirine)
- Daroogooyinka loo yaqaan "Narcolepsy / sleeping apnea"
- Daroogooyinka fasalka Penicillin: nafcillin
- Dawooyinka ka hortaga tiibayda: Priftin
Daawooyinka soo socda waa in aan loo isticmaalin Daklinza:
- Anti-Qalabka: Tegretol, Carbatrol, Equetro, Epitol, Dilantin, Phenytek, Dilantin-125
- Dawooyinka ka hortaga tiibayda: Rifadin
- St. John Wort
Had iyo jeer kugula talin dhakhtarkaaga wixii daawo ah ee aad qaadan karto, oo ay ku jirto dawooyinka miiska lagaa siiyo ama kuwa dhakhtarku qoro.
Tixgelinno dheeraad ah
Daklinza waxay sababi kartaa hoos u dhac weyn ee garaaca wadnaha ( bradycardia ).
Waxaa jirey xaalado ay bukaannadu ku heleen qalabka wadnaha ka dib markii la qaato daroogada daawada ilwareedka , amiodarone , oo leh Sovaldi oo la jaanqaadaya HCV kale oo fayruska tooska ah, sida Daklinza. Iskuduwaha amiodarone Daklinza iyo Sovaldi laguma talin. Haddii aan jirin wax kale oo la heli karo, kormeerka wadnaha ayaa si weyn loogu talinayaa.
Inkastoo daraasaadka xayawaanku aysan muujin wax caddayn ah oo ku saabsan burburka uur-ku-jirta marka uu u soo gudbay Daklinza xiliga uurka, isticmaalka Sovaldi ayaa ka hortagaya isticmaalka noocaas ah. Daaweynta isku dhafka Daklinza / Sovaldi waa in aan loo isticmaalin xilliga uurka. Dumarka da'da dhalmada iyo labadooda lamaane waa inay isticmaalaan laba nooc oo ah uurqaadid marka ay qaadanayaan Daklinza / Sovaldi.
Nabadgelyada Daklinza waa bukaanno beerka lagaga beddelo beerka oo aan weli la dhicin.
Xigasho:
Maamulka Cuntada iyo Dawooyinka Mareykanka. "FDA waxay oggolaatay daaweyn cusub oo loogu talagalay cudurrada cagaarshow nooceeda ee" chronic hepatitis genotype 3 ". Silver Spring, Maryland; saxaafadeed ay soo saareen July 24, 2015.