Sahaminta Furaha Loogu Jiraa Xilliga Mudada Dheer
Daaweynta ficilka ah waa caddeyn ku salaysan caddaynta taas oo HIV-gu lagu hayn karo jeeg la'aan iyadoo aan loo isticmaalin daawooyinka dabadheeraad ah. Marka laga soo tago tallaalka sterilis , oo ah HIV-da si buuxda looga ciribtiri karo jidhka, daaweyn ficil ahi waxay u adeegtaa wax badan oo ka mid ah xannibaadda oo fayrusku aanu awoodin inuu cudur keeno xitaa haddii raadinta fayrusku wali sii socdo.
Waxaa jiray xiiso aad u badan oo ku dhowaad muran badan oo ku hareeraysan rajada laga qabo daaweynta ficilka ah. Françoise Barré-Sinoussi , oo ah wada-helitaanka HIV-ga, ayaa sheegay in 2013 ay si buuxda u aaminsan tahay in daaweynta noocaas ah laga heli karo "gudaha 30ka sano ee soo socda." Taas bedelkeeda, Robert Gallo (oo sidoo kale lagu qiimeeyo helitaanka HIV) waxay tixgelisaa fikradda khalkhalka iyo aaminsan tahay in qeybo ka mid ah aragtida "aysan u muuqan inay shaqeynayaan."
Sida Loo-shaqeeyaha Taabasho u Shaqeyn karo
Mid ka mid ah caqabadaha ugu waaweyn ee wajahaya cilmi-baarayaasha ayaa ah unugyada iyo unugyada jidhka (oo lagu magacaabo kaydadka qadiimka ah ) halkaasoo HIV-gu uu sii wadi karo xitaa wajiga lagu xakameynayo fayraska. In lagu kaydiyo gudaha hannaanka gacanta ee unugyada leh waa astaanta hidda-socodka HIV, oo nidaamka difaaca jidhku aanu awoodin in la ogaado.
Maadaama fayrusku uusan si firfircoon u soo qaadin-laakiin waxaa loo qaadaa si wadajir ah iyada oo loo marayo si isdabajoog ah unugyada martigelinta-waxaa badanaa aan ku dhicin daawooyinka antiretrovoviral (taniyo antiretrovirals ay shaqeynayso marxaladda wareegga nolosha 'fayruska', oo ma aha martida).
Waxaa jira dhowr nooc oo la raadinayo si wax looga qabto arrintan:
- Nadiifi qashinka qarsoon. Cilmi-baareyaasha qaar ayaa tusay, in la kobciyo kaydadka, HIV-da ayaa dib loo soo celin karo oo laga sii deyn karaa meelahooda qarsoon. Tani waxay u oggolaanaysaa ART iyo wakiilo kale oo dhexdhexaadin ah inay si buuxda u cirib tiraan fayruska cusub ee la nadiifiyey, oo ah istaraatijiyad loo yaqaan "kick-kill." Daawooyin dhowr ah ayaa leh awooda ay ku nadiifinayaan kaydadka muhiimka ah ee la siinayo laakiin ilaa hadda, qayb ahaan. Isku darka cusub ee daroogada ayaa la rajeynayaa in la hagaajiyo natiijooyinkaas.
- Ku dhiirigeli jirka in uu soo saaro "unugyo" antibodies. Waxaa jira noocyo ka mid ah borootiinka difaaca jirka, oo loo yaqaanno difaaca jirka, kuwaas oo ay soo saaraan jirka oo ka jawaabaya caabuqa. Qaar ka mid ah kuwan waxay leeyihiin karti u lahaan kara in ay ka takhalusaan HIV. Dhibaatadu waxay tahay in HIV-ga si deg deg ah u dhaco si aan waligeed lahayn noocyo badan oo "killer" oo difaaca jirka ah si loo yareeyo dhammaan noocyada muruqyada. Sannadihii ugu danbeeyay, aqoonyahanada ayaa ogaaday in qaar ka mid ah, dadka naadirka ah ay si gaar ah u takhasusaan difaaca jirka (BnAbs) oo dilaayo noocyo badan oo ah isku-dhafashada HIV. Cilmi-baadhayaashu waxay raadinayaan siyaabo lagu kicin karo walxahan dabiiciga ah ee dhacaya, istaraatiijiyadda taas oo laga yaabo in ay ka caawiso fulinta balan-qaadka "laadkii"
Caddaynta Taageerada Dhaqtarka Wanaagsan
Inkastoo cilmi baaris lagu sameeyo daaweyn ficil ah ayaa miiska saaran muddo sanado ah, saddex dhacdooyin oo gaar ah ayaa bixiyay caddaynta asaasiga ah ee asaasiga ah.
Madaxa dhexdooda ayaa ah hal qof oo la rumeysan yahay in la daaweeyey HIV-da 2009kii. Timothy Brown (Bukaanka Berlin) wuxuu ahaa HIV-da Mareykanka ah ee ku nool magaalada Berlin kaasoo la siiyey lafo-qallajin laf dhab ah oo lagu daweeyo lafo-xanuunkiisa. Dhakhaatiirtu waxay doorteen deeq bixiye unugyo leh laba nuqul oo ka mid ah isbeddelka hidde-celinta ee loo yaqaan CCR5-delta-32, oo loo yaqaan inay iska caabbiyaan HIV-ga dad tiro yar .
Baaritaannada joogtada ah ee la sameeyay markii ugu horreysay ka dib markii la ogaadey in unugyada difaaca HIV ee Brown ee dhiigga uu hoos u dhacay heerarka noocan oo kale ah si loo soo bandhigo dhamaystirka dhammaystirka ee fayraska. Biopsies xaddidan ma xaqiijin wax caddayn ah oo ku saabsan HIV-ga wax kasta oo Brown ah, oo taageeraya sheegashada in ninkaasi ahaa, dhab ahaantii, la daaweeyey. Inkasta oo halista dhimashada loo tixgeliyo in ay aad u sarayso si loo baadho laf-dhabarka lafa-beelka sida ikhtiyaarka daaweynta, kiisku ugu yaraan wuxuu bixiyaa caddaynta in daaweyntu ay dhab ahaantii suurtagal tahay.
Dhanka kale, aqoonyahanno kale ayaa baarayay wakiilo tijaabo ah kuwaas oo awood u leh inay iska nadiifiyaan HIV-yada qashinka qarsoon.
Mid ka mid ah daraasadaha ugu horreeya, oo lagu qabtay Jaamacadda Waqooyiga Carolina 2009 ayaa muujisay in daroogada daroogada loo yaqaan ' histone deacetylase (HDAC)' ay soo celin karaan HIV-ga qarsoon ee heerarka daroogada loo tixgelinayo amaan iyo dulqaad.
Inkasta oo daraasadihii xigay ay soo jeediyeen in adeegsiga hal hal wakiil oo HDAC ay kaliya bixin karto jawaab celin qayb ahaan, waxaa jira caddaymo muujinaya in isku-darka daaweynta HDAC ama noocyada cusub ee daawooyinka ka hortagga kansarka (oo lagu magacaabo xeryaha ingenol) ay si buuxda u daadin karaan HIV kaydka.
Jidka Path
Sida ballan-qaadka ah ee cilmi-baarista oo dhan ay u muuqan karto, waxay kor u qaadaan su'aalaha badan ee ay ka jawaabaan. Madaxa iyaga ka mid ah:
- HIV-ga ka soo saari doonaa kaydadka ay ku filan tahay si loo hubiyo in fayrasku aanu dib u dhicin kaydadka isku midka (ama kuwa kale)?
- Sidee muhiim u tahay in si balaadhan looga takhaluso unugyada difaaca jirka in ay noqdaan daaweyn ficil ah oo lagu ogaaday in kicinta hal unug ee noocaas ah ee noocan ah ay tahay kan ugu fiican?
- Sidee loo hubin karaa in dib-u-dhiska fayruusku uusan dhici doonin sida uu ku dhacay kiiska Mississippi ee carruurta iyo isku day kale oo fashilmay?
Inkastoo aan u muuqano in ay tahay wadada saxda ah, waxaa muhiim ah in la eego cilmi-baarista iyada oo la rajeynayo in la ilaaliyo. Xitaa haddii cilmi-baarayaashu ay sii wadaan furitaanka qarsoodiga ku hareeraysan HIV-ga, midkoodna midkoodna si cad uma sheegin in shuruucda ku saabsan ka hortagga iyo daaweynta HIV ay isbeddeshay.
Haddii ay jirto, marka la eego caddaynta in hore loo ogaado iyo faragelinta ay fure u yihiin daaweynta, muhiimka ah in la sii wado waa, laga yaabo inay ka muhiimsan tahay abid.
Ilaha:
> Hütter, G .; Nowak, D .; Mossner, M .; et al. "Kontoroolka Muddada-dheer ee HIV-ga ee CCR5 Delta32 / Delta32 Qalabka Qalitaanka-Qaadashada." Somali Journal of Medicine. Febraayo 12, 2009; 360: 692-698.
> Archim, N .; Espeseth, A .; Margolis, D .; et al. "Muujinta La-socodka La-qabsiga HIV-ga oo ay ku xirantahay Awoodda Hoos-u-qaadista ee HDAC Isugeynta ee Suberoylanilide Hydroxamic Acid." Cilmi-baadhista Cilmi-baarista ee Retrovirus. Febraayo 2009; 25 (2): 207-212.
> Sáez-Cirión, A ;; Bacchus, C .; Hocqueloux, L .; et al. "Daaweynta Daaweynta Daawada HIV-1 ee Ka-Hortaga Daaweynta Muddada Dheer ee Waqtiga Ka Dib Kala-tegidda Daaweynta Dabaysha Hore ee Antiretroviral" ANRS VISCONTI Study. " Baadhitaanka Patho. Maarso 14, 2013; 0 (3): e1003211.
> Jiang, G .; Mendes, E .; Kaiser, P .; et al. "Dareen-celinta Is-beddelka Hoos-u-qaadista HIV-ga ee Ingenol-3-Angelate, PEP005, NF-kB Targeted Nidaamka Is-dhex-dhexaadinta ee JQ1 Isugeynta P-TEFb. Qulqulatada Pathogens. Julaay 30 2015; DOI: 10.1371 / journal.ppat.1005066.