Waagii hore, daawooyinka dhakhtar qoray ee daaweynta caloosha oo joogtada ah iyo calool-adkaanta madax- xannuun-xannuunka mindhicirka (IBS-C) ayaa xaddidan. Nasiib wanaag, tani way isbedeshaa, tiro dawo ah ayaa la heli karaa iyada oo lagu daaweynayo calool-xanuun joogto ah.
Amitida (agagaarka)
Amitida waxaa ansixiyay FDA si loogu daaweeyo IBS-C, iyo sidoo kale calool-galinta idiopathic (CIC).
Amitida waxay ka shaqeysaa adigoo kordhiya xaddiga cabitaanada mindhicirada iyo sidaas darteed fududeynaya marinka saxarada.
Daawada waxay ku shaqeysaa heerkulka aaladda sida uu bartilmaameedsanayo (firfircooni) borotiinka ku lug leh gaadiidka chloride, sidaas darteed Amitigaa waxaa loo yaqaana dhaqdhaqaaqa kanaalka chloride. Dadka badankooda qaata Amitilaada waxay dareemaan calaamadaha gargaarka 24 saacadood gudahood.
Uma baahnid inaad qaadatid Amitiga haddii aad qabto xannibaad mindhicir ah , la kulanto shuban daran, ama aad uur leedahay ama naas nuujinayso.
Lactulose
Lactulose waa maaddada loo yaqaan 'osmotic stimulants' oo loo isticmaalo daaweynta calool-galinta. Waxaa lagu iibiyaa magacyo kala duwan. Kuwaas waxaa ka mid ah Cephulac, Chronulac, Constilac, Cholac, Constulose, Duphalac, Enulose, Generlac, iyo Kristalose.
Lactulose waa sonkortu ay samayso oo ay bakteeriyadu ku jebiso mindhicirka, habka biyo badani u soo galo xiidanka. Korodhka biyaha ayaa jimicsiga, kordhiya, oo caadiyan saxaradaa.
Miisaanka sare ee saxarada ayaa ka caawiya inuu kiciyo dhaqdhaqaaqa xinjirta, sidaas darteed dhiirigelinta dhaqdhaqaaqa mindhicirka.
Lactulose waxaa guud ahaan lagu taliyaa in loo isticmaalo qaab wakhti gaaban ah. Tani caadi ahaan ma aha xulashada koowaad ee dhaqtarka maadaama ay si xun u dulqaadaneyso (taasoo sababtay in badan oo gaajo iyo gaas) oo marar dhif ahna waxtar badan oo ka duwan fursadaha kale.
Ka hor intaadan qaadin lactulose, hubso in dhakhtarkaagu ogyahay haddii laguu qoondeeyey qalliin, aad qabto cudurka macaanka, ama aad uur leedahay ama naas nuujinayso.
Linzess (linaclotide)
Linzess waxaa ogolaaday FDA si loogu daaweeyo IBS-C iyo CIC. Wadankan Yurub, daawada waxaa loo yaqaan Constella waxana loo ogolaaday daaweynta IBS-C.
Daawada waxaa lagu gartaa sida loo yaqaan 'cyclase-C' agonist. Waxaa loo maleynayaa in ay ka shaqeyneyso kordhinta xaddiga dareeraha ee xiidmaha waaweyn taasoo keentay in tirada sii kordheysa ee mindhicirka iyo xanuunka caloosha oo yaraaday.
Prucalopride
Prucalopride waxaa loo kala saaraa sida 5-HT agonist maaddaama ay dhaqaajiso xayawaanka loogu talagalay serotonin neurotransmitter (5-HT). Nasiib darro, prucalopride weli lama aqbalin isticmaalka FDA oo aan laga helin Mareykanka Waxaa laga helaa Yurub iyo Kanada, iyada oo ay jiraan waxyaabo xadidan oo ku saabsan rijeetada.
Miralax
Si ka duwan daawooyinka kale ee lagu sameeyay boggan, Miralax uma baahna warqad rijeeto ah . Si kastaba ha ahaatee, dhakhaatiirtu had iyo jeer waxay ku taliyaan Miralax sababtoo ah wax ku oolnimada ee yareynta caloosha. Miralax ayaa biyo u gelineysa saxarada, jilciso, iyo u adkeysiga dareenka saxarada.
Zelnorm (tegaserod)
Zelnorm waa dawo loogu talagalay in lagu daaweeyo IBS-C iyo CIC.
Waxa kale oo uu ka shaqeeyaa kor u qaadista xaddiga serotonin neurotransmitter ee unugyada habka xididada habdhiska dareenka .
Iyadoo loo eegayo khataraha caafimaad ee khatarta ah, daawada ayaa kaliya la heli karaa marka ay jirto xaalad degdeg ah. Daawada rijeetada waa inay si toos ah ugu oggolaataa FDA.
Ogeysiis ku saabsan antidepressants
Dawooyinka liddi ku ah antidepressants looma aqbalin sida daaweynta caloosha. Si kastaba ha ahaatee, sababtoo ah heerka niyadjabka ee bukaanka qaba IBS iyo xaqiiqda ah in antidepressants ay yeelan karto hanti-xanaano oo wax-ku-ool ah, dhakhtarku wuxuu u qori karaa antidepressant qof shakhsi ah oo la xiriira IBS-C .
Daawada ka-hortagga niyad-jabka ayaa loo doortaa qof khibrad u leh calool-fadhiga wuxuu ka imanayaa fasalka loo yaqaan 'serotonin reuttiaters inhibitor' (SSRIs).
Kuwani waxay u badantahay inay sababaan calool-galinta. Tusaalooyinka SSRIs waxaa ka mid ah Celexa, Lexapro, Prozac, Paxil, iyo Zoloft.
> Isha:
> Ford A, et.al. Jaamacada American College of Gastroenterology Sawir ku saabsan Maareynta Xanuunka Calaamadaha Dareenka Xanuunada iyo Cudurka Idiopathic Chronic . Somali Journal of Gastroenterology. 2014; 109: S2-S26. doi: 10.1038 / ajg.12.187
> Maamulka Cuntada & Dawooyinka Mareykanka. Zelnorm (tegaserod maleate) Macluumaadka. 2016. https://www.fda.gov/Drugs/DrugSafety/ucm103223.htm.