Prucalopride waa daawo loogu talagalay in lagu daaweeyo caloosha joogtada ah - Dhibaato caafimaad oo lagu garto marxalad adag iyo marxalad adag oo ah saxaro muddo dheer ah, oo ay weheliyaan waxyaabo kale oo calaamado ah oo murugo leh sida gariir, caloosha, iyo matag. Doorashada daaweynta dhaqameed ee caloosha joogtada ah waxay ku lug leedahay inta badan cuntada iyo isbeddelka hab-nololeedyada iyo / ama calool-xanuunka.
Prucalopride ayaa haatan laga heli karaa Yurub, iyada oo ku jirta magac magaciisu yahay "Resolor" iyo Canada sida "Resotran". Hay'ada Daawada Yurubta (EMA) waxay ogolaatay isticmaalka prucalopride (Resolor) kaliya daaweynta caloosha joogtada ah ee haweenka aan ka jawaabin isticmaalka jejebiyeyaasha . Daraasad ayaa la sameeyaa si loo helo oggolaansho EMA si loogu isticmaalo daawada prucalopride ee ragga qaba caloosha joogtada ah.
Sidee Shaqada Prucalopride uga shaqeyn kartaa?
Prucalopride waxaa lagu gartaa sida 5-HT4 agonist. Taas macnaheedu waxa weeye in ay kicineyso 5-HT4 soo-saarayaasha si loogu daaweeyo serotonin neurotransmitter. Hawlgalkani waxaa loo maleynayaa in uu kordhinayo nidaamka habdhiska mindhicirka isaga oo sii kordhinaya cagajiidka, ama dhaqdhaqaaqa muruqyada mindhicirada ee ka soo baxa jirka, ka dhigista saxarada si sahlan oo loo dhaafo oo ay keento dhaqdhaqaaqyo badan oo soo noqnoqda.
Prucalopride waa isku mid ah daawooyinka sida Zelnorm.
Hase yeeshee, prucalopride waxaa loo qorsheeyay in ay qaaddo tallaabo kale oo jidhka ka mid ah si loo yareeyo suurtagalnimada calaamadaha dhifka ah, laakiin calaamadaha halista ah ee keena cudurka Zelnorm ee laga saaray suuqa.
Sidee waxtarkeedu ugu qaalisan yahay Prucalopride marka la daaweynayo calool-xanuunka joogtada ah?
Waqtiga tijaabada caafimaadka, taariikhda qalliinka, ayaa lagu muujiyey in ay ka sarreyso xuddurrada meelaha soo socda:
- Kordhinta joogtada ah ee dhaqdhaqaaqa mindhicirka iyo saxarada oo dhameystiran.
- Hagaajinta aragtida bukaanka ee tayada nolosha.
- Ku soo noqoshada aragtida bukaanka ee calooshu ku yar tahay dhibaato.
Maxay Yihiin Saamaynta Lidka ah ee Prucalopride?
Daraasadaha ilaa taariikhda, saameynaha soo socda ayaa la soo maray:
Prucalopide ma caawineysaa IBS?
Dib-u-eegista cilmi-baaristii ugu dambaysay, College College of Gastroenterology ayaa ku soo gebogebeysay in cilmi-baaristu ay taageertey wax-ku-oolnimada prucalopride ee caloosha iyo IBS-C labadaba. Cilmi-baadhayaasha ACG waxay xusuusinayaan in prucolopride uusan haynin khatarta Zelnorm ee dhacdooyinka wadnaha ku dhaca.
Yay tahay inaanay qaadin Pranjalopide?
Dadka qaarkood waxay halis sarreysa ugu jiraan inay horumariyaan dhibaatooyin halis ah ama dhibaatooyin ka yimaada qaadashada prucalopride. Kuwaas waxaa ka mid ah dadka:
- Tijaabin la'aanta daroogada ama mid ka mid ah maaddooyinka
- Dhibaatada kaansaarida u baahan ee loo yaqaan 'dialysis'
- Dhibaatada mindhicirka ama xannibaadda
- Cudurka dabaysha
- Xaalado daran oo barar ah oo ka yimaada xiidmaha
- Cudurada halista ah iyo kuwa caafimaad ahaan aan degganeyn, gaar ahaan arrhythmias ama cudurada wadnaha ischaemic.
Ilaha:
Ford, A., et.al. " Kulliyadda Maraykanka ee Gastroenterology Sawir Qaadashada Maareynta Calaamadaha Dareenka Sawirka Saxarada iyo Cudurka Dabaysha Xanuunada Xanuunada " " American Journal of Gastroenterology 2014" 109: S2-S26.
Ford, A. & Suares, N. "Saamaynta macmacaanka iyo daaweynta fayo-qabatinka ee kudheerta ilmagaleenka joogtada ah: dib-u-eegis nidaamsan iyo mala-dhaf" Gut 2011 60: 209-218.
Maneerataaraporn, M., Chang, L., & Chey, W. "Horumarinta Faragelinta Faragalka ee loogu talagalay Calaamadaha Calaamadaha Calaamadaha Calaamadaha" Xarumaha Gastroenterology ee North America 2011 40: 22-243.
"Movetis waxay bilawday tijaabada daaweynta wajiga III ee la socota prucalopride ee bukaanka labka ah ee caloosha joogtada ah" Movetis NV War Saxaafadeed September 24, 2010.
"Dib-u-dejin" Hay'adda Daawooyinka Dawooyinka ee Yurub oo la aasaasay March 17, 2011.
Quigley, E. "Prucalopride: Nabadgalyada, Waxtarka iyo Kartida Codsiyada Horudhaca Ka Soo Kabashada Gastroenterology 2012 5: 23-30.