Berberine waa kiimiko laga helo noocyo badan oo dhir ah, sida jilif, xididada, rhizomes ee dhirta laga helo dunida oo dhan, iyo sidoo kale kordhinta cuntada dukaamada caafimaadka. Faa'iidooyinka caafimaadka leh ee berberine ayaa loo yaqaan qarniyo badan waxaana loo isticmaalay in lagu daaweeyo xaalado caafimaad oo kala duwan oo ah dawooyinka Hindiya iyo Shiinaha, taas oo ka bilaabanta sonkorowga ilaa caabuqyada.
Sababtoo ah midabka huruudka ah, waxaa sidoo kale loo isticmaalay dhaqanada qaar si dharka loo xiro.
Sanadihii la soo dhaafay, berberine oo ka go'ay dhirta qaar ayaa sidoo kale lagu baray daaweynta caabuqa, kansarka, arthritis iyo qalalaasaha wadnaha. Xitaa waxaa jira cadeymo muujinaya in berberine laga yaabo inuu waxtar u leeyahay hoos udhaca heerarka kolesteroolka iyo triglyceride.
Daraasadihii dhowaa muujinaya ballanqaad
Inkastoo ay jiraan daraasado bini'aadan oo dhowr ah oo baaraya saamaynta berberine ee heerarka lipid , badi daraasaddan ayaa lagu sameeyay hamsters iyo jiirka. Berberine ee daraasaddan waxaa laga soo ururiyey noocyo kala duwan oo geedo, oo ay ku jiraan xidid dahab ah iyo Huanglian.
Daraasadaha xayawaanka, berberine waxaa loo maamulay meel kasta oo u dhexeysa 100 iyo 250 mg / kg miisaanka jidhka maalin kasta. Berberine wuxuu u muuqday inuu hoos u dhigo wadarta guud ee kolestaroolka hoos u dhigma ilaa 31%. Intaa waxaa dheer, heerarka triglyceride ayaa hoos u dhacay ku dhowaad 32% iyo heerarka kolestaroolka LDL ayaa hoos u dhacay 25%.
In kasta oo HDL la baaray, berberine uma muuqan mid si weyn u saameynaya.
Daraasadaha bani-aadminimo ee bini-aadanka ah ayaa waxay u muuqdaan in ay ku habboon yihiin daraasadaha lagu sameeyay xayawaanka. Berberine 500 mg waxaa loo maamulaa shakhsiyaadka qaba heerarka sare ee kolestaroolka laba illaa saddex jeer maalintii ilaa saddex bilood. Natiijo ahaan, wadarta guud ee kolestaroolka ayaa hoos udhacay ilaa 29%.
Triglyceride iyo heerarka "kolesterol" LDL ayaa sidoo kale hoos u dhacay iyadoo ay sabab u tahay qaadashada berberine. Tusaale ahaan, heerarka "kolesterol" LDL ayaa hoos u dhacay celcelis ahaan 21%, halka heerarka triglyceride ay hoos u dhaceen meel kasta oo u dhaxaysa 22 iyo 35%. Heerarka HDL, dhinaca kale, uma muuqan in ay si weyn u badasho marka lagu daro berberine.
Sidee Berberine Hoos u Dhici Karaa?
Inkasta oo qaabka uu berberine u shaqeeyo hoos u dhigidda kolestaroolka aan si buuxda loo garanayn, saynisyahannadu waxay leeyihiin dhowr aragti oo ku saleysan daraasaddan. Waxaa loo maleynayaa in berberine uu awood u leeyahay inuu kordhiyo tirada LDL-du-qabtayaasha ee beerka, kaas oo gacan ka geysan kara in kor loo qaado cadadka kolestaroolka LDL ee jirka. Berberine ayaa sidoo kale u muuqda in uu ka shaqeynayo dariiqyada calaamadaha jidka ah ee ku lug leh dufanka jirka. Berberine ayaa sidoo kale lagu muujiyay in uu u dhaqmayo si lamid ah phytosterols isagoo xakameynaya nuugista neefsashada ee mindhicirka yar.
Haddii aad qaadatid Berberine si aad u hooseysa kolestaroolka?
Daraasaadka baaritaanka isticmaalka berberine si hoos loogu dhigo kolesteroolka ayaa u muuqda mid rajo leh, si kastaba ha ahaatee, baaritaan dheeraad ah ayaa loo baahan yahay ka hor inta aan lagu darin wakiilka kolestaroolka lagu taliyey.
Berberine waa in aan la siinin dhaladka, sababtoo ah waxay keeni kartaa dhaawac maskaxeed, ama dumarka uurka leh iyo haweenka naas nuujinaya (waxay dhaawici kartaa ilmaha caloosha ama ilmaha dhasha).
Berberine lafteeda ayaa adagtahay in la helo kaalmo dheeri ah si aad u yareyso lipids-kaaga. Si kastaba ha noqotee, dhirta dhirta iyo geedaha badani waa ganacsi la heli karo kuwaas oo ku jira xaddi badan oo berberine ah, oo ay ku jiraan:
- Xiddiga Goldenseal ( Hydrastis canadensis L )
- Xilliga Rootka Ohio ( Berberis aquifolium )
- Barberry ( Berberis vulgaris )
- Huanglian ( Coptis chiensis )
Waxyaabaha berberine waxay ku kala duwan yihiin dhirta geed kasta. Tusaale ahaan, dahabka waxaa laga yaabaa inuu ku jiro meel kasta oo u dhexeeya 1% iyo 6% ee berberine. Sidaa darteed, waxaad u baahan tahay inaad calaamadiso calaamadda dheeraadka ah si aad u ogaato qiyaasta berberine, halkii aad ka heli laheyd dhir daaweedka, kiniin kasta.
Si aad u aragto saameyn ku yeelanshada kolestaroolka lagu xusay cilmiga aadanaha, waxaad u baahan tahay inaad isticmaasho 500 mg oo ah berberine laba illaa saddex jeer maalintii.
Inkasta oo si sahlan loo heli karo, waa inaad la tashatid bixiyahaaga daryeelka caafimaadka ka hor inta aadan ku darin berberine - ama wixii dhir daawo ah oo kiimiko ah oo kiimiko ah oo kiimiko ah - ku jira habka lipid-lowering. Dhibaatooyinka kale ee la soo sheegay alaabooyinka ay ku jiraan berberini waxaa ka mid ah madax xanuun, xanuunka caloosha, iyo lallabbo. Dhibaatooyinka caleemahaas ku jira xaaladaha caafimaad qaarkood looma ogeyn, loomana ogaan karo in daawada berberine-ka ee ku jirta ay wax ka dhexgali karto daawooyinka kale ee aad qaadato.
Ilaha:
Abidi P, Chen W, Kraemer FB, Liu J. Goobta dhirta daawada ee dahabiga ah waa wakiil dabiici ah oo LDL ah oo leh qaybo badan oo bioactive iyo habab cusub. J Lipid Res 2006; 47: 2134-2147.
Cicero AFG, Men S. Berberine: Saamaynta dheef-shiid kiimikaadka iyo kuwa wadnaha ku dhaca ee tijaabooyinka tijaabada ah iyo baaritaanka. Nutrition Supp Supp 2009: 1: 1-10
Heerka caadiga ah. (2015). Berberine [Monogram].
Pirillo A, Catapano AL. Berberine, alkalogen rooti ah oo leh lipid iyo qaababka glucose-hoos udhaca: laga bilaabo caddaynta faytanka ee daraasadaha kiliiniga. Atherosclerosis 2015; 243: 449-461.