Khudaarta cagaaran waxay ka hortagtaa burburinta daawooyinka qaarkood.
Haa, qaboojiyaha casiir-buuxa ee fitamiinada iyo nafaqooyinka. Dad badan, hal galaas oo casiir ah ayaa ah hab caafimaad leh oo lagu bilaabi karo maalinta. Si kastaba ha ahaatee, haddii aad ku jirtid daawooyin gaar ah, sida dawooyinka wadnaha qaarkood ee loo yaqaan 'statins', waa inaad iska ilaalisaa inaad cabto cabitaanka koobabka leh markaad qaadato daawooyinkaas. Casiirka joodariga ayaa xakamayn kara awoodda jirkaaga ee aad ku jebin karto dawooyinkan, taas oo markaa, u horseedi karta saameyn xun.
Khudradda Cuntada iyo Xaaladaha qaarkood Ha isku qasin
Khudaarta cagaarka ah iyo walxaha qaarkood (loo isticmaalo daaweynta kolestaroolka sare) sida Lipitor (atorvastatin), Mevacor (lovastatin), iyo Zocor (simvastatin) ha isku darin. Khudaarta cagaaran waxay ka hortagtaa nidaamyada enzymes kaas oo gacan ka geysanaya burburinta daraasad daawo, oo ay ku jiraan Lipitor, Mevacor, iyo Zocor .
Haddii aad cabto casiir cabitaan leh markaad qaadato mid ka mid ah daawooyinkan, wax badan oo ka mid ah daroogooyinka ' firfircoonida ' ayaa laga yaabaa inay gasho dhiiggaaga. Tani waxay keeni kartaa saameyn xun, sida cillad muruq oo halis ah ama dhaawac beerka ah. Si khaas ah, miir khudradda xayawaanku wuxuu joojiyaa daroogada (beerka) habka enzyme P450, taas oo jabisa daroogooyinka.
Adigoo miyir beelaya enzimka beerka, qaybta firfircoon ee firfircoon waxay saameysaa jirkaaga. Si kale haddii loo dhigo, saameynta dawooyinka dawada ee Statin ayaa kor u kacda dadka isticmaala cabitaanka liinta. Dhibaatooyinka xun ee hanti-dhawrka waxaa ka mid ah musqusha iyo beerka waxyeelo.
Cytokras P450 enzymes ayaa lagu kaydiyaa reticulum-ka unugyada ee laga helo unugyada aan laga helin oo keliya beerka laakiin sidoo kale kelyaha, mareenka caloosha iyo mindhicirka.
Noocyadaas P450 waxay jebiyaan daroogooyinka iyaga oo ka qaadaaya oksida. Marka laga soo tago casiirka shiidan, farsamo ahaan furanocoumarins oo casiir ah, waxyaabo kale oo ka hortaga cytochrome P450 enzymes oo ay ku jiraan cimetidiin (histamine blocker loo isticmaalo daaweynta GERD), erythromycin (antibiyootiko) iyo isoniazid (dawada loo isticmaalo daweynta qaaxada).
Fadlan maskaxda ku hay in ay jiraan daroogo badan oo badan oo la xariira cytochrome P450, iyo haddii aad qabtid wax su'aalo ah oo ku saabsan isdhexgalka, waa inaad kala hadashaa dhakhtarkaaga. Dhakhtarkaagu sidoo kale waa inuu hubiyaa haddii daawooyinka aad qaadatid midkood uu leeyahay isdhexgal xumo ama mid kale oo aad cuntid.
Waqtiga aad qaadatid mid ka mid ah daawooyinkan iyo wakhtiga aad cunayso rooti ama cabitaanka casiirku ma yareeyo khatarta ah ee saamaynta daawada ee la xariira daroogada - isdhexgalka wuxuu dhici karaa illaa saddex maalmood kaddib markaad qaadatid xayawaanka. Tani waxay ka dhigan tahay in aadan cabi karin cabitaanka macaan ee subaxdii ka dibna qaad daawadaada waqti dambe maalinta.
Doorashada Dawooyinka
Waxaad haysataa fursado dhowr ah:
- Waxaad ka soo saari kartaa raashin ka sameysan raashinkaaga iyo inaad beddesho miraha kale iyo miirka khudradda, ama
- Haddii aad rabto in aad sii wadato isticmaalka alaabada dufanka leh, la hadal dhakhtarkaaga wixii ku saabsan isticmaalka daawo kale.
Dhawr shinni oo la heli karo ma dhexgalaan cabitaanka sharaabka oo ammaan ah. Kuwaas waxaa ka mid ah:
- Crestor (rosuvastatin)
- Lescol (fluvastatin)
- Pravachol (pravastatin)
Macluumaad Dheeraad ah
Haddii aad qabtid wax su'aalo ah oo ku saabsan isdhexgalka daroogada ee cabitaanka saliidda, fadlan kala hadal taxaddahaan dhakhtarkaaga.
Fadlan xusuuso in dhakhtarkaagaagu yahay ilal aad u fiican oo macluumaad ah iyo in uu kaa caawiyo hagaajinta daaweynta iyo ka shaqeynta si loo hubiyo caafimaadkaaga caafimaad.
Ilaha la Xushay
Qodobka cinwaankiisu yahay "Isdhexgalka mukhadaraadka ee sababo cytochrome P450" by CC Ogu iyo JL Maxa oo lagu daabacay Xarunta Caafimaadka ee Jaamacadda Baylor sanadkii 2000.
Trevor AJ, Katzung BG, Kruidering-Hall M. Agent Antifungal. In: Trevor AJ, Katzung BG, Kruidering-Hall M. eds. Qalabka Faransiiska Katzung & Trevor: Dib-u-eegista & Guddiga Dib-u-eegista, 11e . New York, NY: McGraw-Hill; 2015. Lasoo gooyey Febraayo 29, 2016.