Wadajir ahaan, pannus waxaa lagu qeexay unug aan caadi ahayn oo dheellitiran (sidoo kale waxaa loo yaqaannaa synovium ama lafta derbiga ) kaas oo daboolaya naqshad jilicsan , nooca kilyaha laga helo qaybaha. Maaddaama synovium uu sii weynaado oo sii kordhayo, wadajirku wuxuu dhab ahaantii ku buuxiyaa synovium iyo synovium aan caadi aheyn oo ku wareegsan qashinka loo yaqaan 'cartilage', ugu dambeynna soo saarista nabarrada.
Xanuunka arthritis-ka ee rheumatoid-ka ah, xanjo-xuubka ayaa caadi ahaan ka bilaabma dhinacyada isgoysyada. Sida pannus u socdo, waxay soo gali kartaa lafaha iyo lafaha lafaha , iyo burburinta dhismayaasha ku xeeran, sida kaabaha iyo wadnaha.
Isbarbardhigida Pannus ee Osteoarthritis iyo Rheumatoid Arthritis
Maaha wax badan oo loo yaqaan 'pannus' osteoarthritis oo loo yaqaan 'pannus' ee rheumatoid arthritis . Cilmi-baadhayaashu waxay daraasad ku samaysay ujeedada lagu barbardhigay osteoarthritis pannus oo leh rheumatoid arthritis pannus in vitro (jawiga sheybaarka) ee 2008. Natiijooyinka lagu daabacay Rugaha iyo Rheumatolojiyada waxay u egtahay mid la mid ah osteoarthritis iyo rheumatoid arthritis pannus - laakiin sababta oof-wareenka osteoarthritis-da dusha sare laakiin aan keenin nabarrada margaanka ah ee sida caadiga ah lagu arko rheumatoid arthritis lama sharaxin.
Daraasadaas, nudaha pannus iyo synovial waxaa laga helay 5 bukaan ah osteoarthritis iyo 5 rheumatoid arthritis bukaanka inta lagu jiro arthroplasty (badalaad wadajir ah), ka dibna waxaa lagu beeray oo la bartay.
Pannus waxaa lagu qeexay qorayaasha daraasadda sida "unugyada microscopic invasive granulating covering cover dermatus". Dhammaan maadooyinka daraasadda waxay qabeen fareemo iyo fibrous. Kobcin isku-dhafan ayaa ku fidiya infakshan, waxaana hoos u dhac ku yimaadda borotiinka maqaarka ee dheeraadka ah ee laga helo shaybaarrada unugyada laga helay.
Cudurka kondrocyte wuxuu ka yaraa kiniiniga osteoarthritis-ka marka loo eego kilyaha rheumatoid arthritis. Cudurka osteoarthritis-ka ee synovial ayaa leh heerar hooseeya ee proteoglycans marka loo eego unugyada rheumatoid arthritis synovial. Noocyada nooca kolajka II ah ayaa sidoo kale ka hooseeya kilyaha osteoarthritis marka loo eego kilyaha rheumatoid arthritis. Heerarka sare ee interleukin-1-beta ayaa lala xiriiriyay cudurka rheumatoid arthritis-ka marka la barbar dhigo osteoarthritis pannus. Heerarka sare ee TNF-alpha, IL8, iyo TIMP-1 waxay la xidhiidheen labada osteoarthritis iyo rheumatoid arthritis pannus.
Khadadka hoose
Waxaa lagu soo gabagabeeyay in rheumatoid arthritis-ka iyo osteoarthritis pannus ay leeyihiin calaamadaha cytokine iyo anti-inflammatory cytokine . Sababta loo yaqaan 'pneus osteoarthritis' ma keento dabacsanaan aan caadi aheyn sida rheumatoid arthritis ayaan weli la ogeyn.
Marka laga reebo finanku ka mid ah isku-buufiyooyinka ku dhaca osteoarthritis iyo rheumatoid arthritis, pannus waxay ku sameysmi kartaa meelo kale, sida korriinka, ama qalinjebka wadnaha. Sida pannus u koraayo, waxay u muuqan kartaa caan u eg.
Ilaha:
Rheumatoid Arthritis: Sahan lagu sameeyo qaababka MRI ee Nidaamka Musqulaha. Hong Kong Journal of Radiology. Munk et al. 2002; 5: 63-68.
Osteoarthritis iyo rheumatoid arthritis pannus waxay leeyihiin sifooyin qumman oo isku mid ah iyo jawaabta cytokine ee farsameysan. Furuzawa-Carballeda J. et al. Reynoloji-klinikada iyo tijaabinta. 2008 Jul-Aug; 26 (4): 554-60. http://www.ncbi.nlm.nih.gov/pubmed/18799084
RA. Macluumaadka Arthritis. Johns Hopkins Sebtember 24, 2013.
http://www.hopkinsarthritis.org/arthritis-info/rheumatoid-arthritis/ra-pathophysiology-2/