Miyuu Nitric Oxide ka danbeeyaa Xaaladahan?
Qaar ka mid ah cilmi-baarayaasha ayaa sheegaya in cudurka diiqada daba-dheeraaday (CFS ama ME / CFS ) iyo fibromyalgia (FMS) ay sababi karaan sababo caadi ah. Mid ka mid ah cilmi-baarayaasha ayaa sheegaya in sababtu tahay nitric oxide iyo in ay sidoo kale mas'uul ka tahay dareemayaasha badan ee dareemida (MCS) iyo xanuunka dhimirka ka dib (PTSD).
Martin Pall, PHD, oo ah borofisar ku takhasusay maadada makhaayadda ee Jaamicadda Gobolka Washington wuxuu bilaabay in uu eego ME / CFS ka dib markii lagu ogaaday.
Nuxurka aragtidiisa ayaa ah in walaaca gaaban ee mudada gaaban uu keeno dhisidda dabiiciga ah ee ku dhaca aaladda dabiiciga ah, kaas oo billaabaya marxalad xun oo keeneysa jirro muddo dheer ah.
Waxaa muhiim ah in la xusuusto in nidaamkaan yahay mid tijaabo ah oo aan si cilmi ahaan loo xaqiijin. Si kastaba ha ahaatee, tiro sii kordhaysa ee daraasado, si kastaba ha ahaatee, waxay taageertaa aragtida dariiqooyinka oxidative-ka ah ee aan shaqaynayn, dadka qaarkiis ayaa tijaabiyay qawaaniinta ayaa sheegaya in ay u shaqeysay.
Macluumaadka halkan looguma talagalin in aad taageerto ama beensatid aragtida Pall laakiin halkan ayaa kugula jira inaad ku wargeliso aragtida iyo hababka daaweynta ee aad heli kartid si aad u gaartid go'aamo wargalin ah. Waxaa muhiim ah in dhakhtarkaagu ku daro go'aanka daaweyntaada iyo in laguu kormeero wixii isbedel ah ee caafimaadkaaga.
Nitric Oxide ee jirkaaga
Nitric oxide (MAYA) dhamaantiis jidhkaaga ayey ka sareysaa waxayna doorataa door muhiim ah sida saamaynta gaadiidka oksijiinta ee unugyadaada iyo gudbinta dareen-celinta dareenka.
Ilaa dabayaaqadii 1990-yadii, si kastaba ha ahaatee, waxaa loo tixgeliyey sun ah waxaana Pall loo arkaa in uu sumoobo aragtihiisa. Daraasado badan ayaa muujinaya isbeddelada nidaamyada dhexe ee dareemayaasha ee FMS iyo ME / CFS, iyo Pall ayaa sheegaya in isbeddeladani ay u baahan yihiin heerar sareeya NO.
Pall ayaa sheegaya in heerka sare ee heerarka NA ee nidaamka dareenka dhexe, ayadoona, keena heerarka sare ee peroxynitrite, kaas oo sababa waxyeelo unug.
Sidee ku heli kartaa wax badan MAYA jidhkaaga? Fallaadku wuxuu bixiyaa 12 walbahaarro suurtagal ah, 8 oo horseedaya koritaan toos ah, 4 oo horseedaya mid aan toos ahayn. Dhibaatooyinka tooska ah waa:
- Caabuqa fayraska (ME / CFS, FMS)
- Infekshanka bakteeriyada (ME / CFS, FMS)
- Dhibaatada jirka (ME / CFS, FMS, PTSD)
- Kaarboon moono oksaydh (O / CFS)
- Ka-soo-cayayaanka sunta cayayaanka ee sunta ah (ME / CFS, MCS)
- Cudurka Toxoplasmosis (ME / CFS)
- Soo-gaadhista dareeraha (organic) qasacadaysan (MCS)
- Cudurada maskaxda (FMS secondary)
Dhibaatada kale ee 4aad waxay kicisaa jawaab taas oo horseedaysa firfircoonida NMDA ee kordhaya, taas oo la ogyahay inay kordhinayso heerarka NO iyo peroxynitrite (ONOO-). (Reseptors NMDA waxay u diraan calaamadaha maskaxda waxayna ku lug yeelan karaan dhaawaca unugyada.) Dareesayaashaasi waa:
- Cadaadiska nafsiga ah (FMS, PTSD)
- Soo-saarista Cigaatoxin (laga bilaabo cuntada badda) (ME / CFS)
- Cayayaanka sunta ah ee loo yaqaan "Organochlorine Pesticides" (MCS)
- Pesticides Pyrethroid (MCS)
Fiiro gaar ah: Heerarka darajada sidoo kale waxay kordhineysaa waxyaabo fiican oo wanaagsan, sida marka aad jimicsi sameyso, cun cun cunto yar, xoojin nafaqadaada ama sigaar joojinta, dhammaan khubarada ay tixgeliyaan faa'iidada dadka leh FMS iyo ME / CFS. Cilmi-baareyaasha badani waxay tixgeliyaan heerar sare NO-ga si ay ugu fiicnaadaan caafimaadkaaga.
Wareegga Wicitaanka
Pall wuxuu soo jeedinayaa in marxaladda cagajuglaha ah ay sababto in la abuuro NO, waxay ku dhacdaa wareega xaddidan oo ka kooban dhawr wareeg oo isdaba-joog ah.
Laga soo bilaabo halkaas, waxay helaysaa farsamo aad u adag oo ay ku adagtahay in la fahmo illaa aad dhab ahaantii aqoon u leedahay biochemistry. Haddii aad tahay, Pall wuxuu leeyahay sawir dhammaystiran boggiisa. Inta kale ee naga mid ah, halkan waa tusaale tusaale ah oo kaliya hal wareeg oo 5-talaabo ah:
- Heerka sare ee heerka A wuxuu kordhiyaa heerka peroxynitrite;
- Kororka peroxynitrite wuxuu keenaa cadaadiska oksidheer (dhisidda unugyada molecules ee waxyeellada unugyada ah.) Daraasadaha waxay isku xidhaan cadaadiska oksaydhiga ee ME / CFS);
- Murugada Oxidative waxay kicineysaa NF-kB (oo xukuntay saamaynta geedka ee ku lug leh difaaca jirka iyo shaqada gacanta);
- NF-kB waxay kordhisaa soosaarka unugga enzme iNOS (soodhada loo yaqaan "nitric oxide");
- INOS waxay kor u qaadeysaa heer darajo, waxaanan ku laabannaa hal tallaabo.
Pall ayaa ku magacawday wareegga munaasabka ah ee NO / ONOO- (oo loo yaqaan "maya, oh no!"). Waxa uu sheegayaa inuu ka dhaco heer maskaxeed, taas oo ah sababta ay hal unug u jiri karto xanuunka iyada oo kuwa ku xeeran ay wanaagsan yihiin. Waxa kale oo ay sharxeysaa sababta calaamadaha u kala duwanaan karaan si ka duwan qof qof kale.
Calaamadaha la wadaago
Pall wuxuu leeyahay walxaha NO / ONOO-wareegga ayaa sharxi kara calaamadaha astaamaha ee CFS, FMS, MCS iyo PTSD. (Wuxuu u soo bandhigaa sababo aan la garanayn, oo aan la aqoonsan.) Calaamadahaasi waxaa ka mid ah:
- Barashada iyo xusuusta xusuusta,
- Daal iyo hurdo hurdo,
- Xanuun aad u daran,
- Murugada iyo walwalka / weerarka argagaxa,
- Immune disfunction,
- Calaamadaha cudurka mindhicirka,
- Xasaasiyadda cuntada,
- Cilmi-galinta astaan-darrada / dhiig-baxa (hoos u dhac ku yimaada cadaadiska dhiigga markaad istaagtid dawakhaad.)
Jebinta wareegga
Si loo jebiyo wareegga, Pall ayaa sheegeysa in ay u baahan tahay "hoos u dhigga," taas oo asal ahaan ka dhigan tahay inuu hoos u dhigo isaga oo baabi'inaya waxyaabaha wax kicin kara. Tusaale ahaan, haddii fekerku kaa sii xumaado, waa in la dhimo ama la maareeyo. Taas bedelkeeda, wuxuu aaminsan yahay in kakanaanta wareegga ahi ay u baahan tahay noocyo badan oo daaweyn ah.
Qoraalka Pall's on the NO / ONOO-cycle wuxuu muujinayaa waxyaabo badan - waxyaabo badan oo nafaqo leh - oo uu saadaaliyay inuu hoos u dhigayo wareegga. (Xusuusnow in aragtidan aan la hirgelin oo wakiiladani aan la daaweynin daaweynta kooxdan cudurada.) Waxa kale oo ay liis-garaynaysaa habka daaweynta loo isticmaalo shan dhakhtar oo helay guusha daaweynta hal ama in ka badan shuruudahaas oo sheegaya in daaweynta dhammaantood ay u badan tahay inay hoos u dhacaan xakameynaya wareegga. Sida dhammaan fursadaha daaweynta, waa inaad kala hadashaa dhakhtarkaaga wixii ku haboon.
Pall ma aha midka kaliya ee tilmaamaya nitric oxide sida cudur macquul ah. Qaar ka mid ah cilmi-baadhayaasha oo baadhaya doorka NO, gaar ahaan fibromyalgia, ayaa ku baaqaya in daraasad lagu sameeyo in haddii antioxidants daaweyn wax ku ool ah.
Cilmi baarista
Tan iyo markii kitaabkii Pall uu soo bandhigay aragtihiisa 2007-dii, qiime cad oo cilmi-baaris ah ayaa lagu sameeyey doorka nitric oxide xaaladahaas.
Maqnaanshaha ME / CFS, dhowr daraasado (Sachdeva, Kumar, Gupta) ayaa u muuqday inay taageerayaan aragtida, ugu yaraan moodada-moodooyinka.
Waxbarashooyinka bani'aadamka qaarkood ayaa sidoo kale deyn ku leh dammaanadda, oo ay ku jiraan daraasaddan sannadkii 2010 (Suarez) oo muujisay qiyaaso aan caadi ahayn oo la yiraahdo metabolosyo aan jirin ka dib markii lagu jimicsado ME / CFS. Cilmi-baaris lagu daabacay 2014-ka (Morris) ayaa soo jeedinaysa in culeyska oxidative iyo neef-ba'an uu ku wadi karo waddooyinka difaaca jirka iyo gawaarida difaaca oo xajiya hababka cudurrada cudurka.
Si kastaba ha ahaatee, ugu yaraan hal daraasad (Meeus) ma aysan helin wax isdhexgal ah inta udhaxeysa NO ee dhiigga iyo waxqabadka ME / CFS.
Daraasado dhowr ah (Cimen, Fatima, Sendur) waxay sidoo kale taageertaa aragti ka mid ah kaqeybgalka nitric oxide FMS. Kale (Kim) ma helay farqi weyn oo ku jira heerarka NO ee u dhexeeya kooxda FMS iyo kontoroolka caafimaadka qaba.
Miyay Isku Diiwaangelinta Saxda Ah Loogu Noqon Karaa?
Kaliya waxaad go'aamin kartaa daaweynta kuu habboon adiga, waana in aad hubsataa inaad kala hadasho kala doorashada daaweynta dhakhtarkaaga. Marka lagu daro waxyaabo badan oo ka mid ah qodobbadan oo u baahan ka qaybqaadashada dhakhtarka, waa inaad sidoo kale si dhow ula socotaa si loo hubiyo in daaweyntu aysan saameyn xun ku yeelanayn caafimaadkaaga.
Ilaha:
Cimen OB, et al. Daawada xanuunka. 2009 Jul-Aug; 10 (5): 813-8. Arginase, hawlaha NOS, iyo sifooyinka bukaanka ee bukaanka fibromyalgia.
Fatima G, Das SK, Mahdi AA. Raajo iyo daaweyn dhab ah. 2013 Nov-Dec; 31 (6 Qalabka 79): S128-33. Dhibaatada Oxidative iyo xuduudaha antioxidiga iyo maadada biraha ee bukaanka qaba fibromyalgia syndrome: saameyn ku yeesha jirrooyinka cudurka.
Gupta A, Vij G, Chopra K. Journal of neuroimmunology. 2010 Sep 14; 226 (1-2): 3-7. Kaalinta suurtagalka ah ee buufiska oksidheerka iyo firfircoonida difaaca jirka ee qaabka mashiinka dareenka dufanka daba dheeraadka ah iyo tiyuuca la yiraahdo laga soosaaray huurka.
Kim SK, iyo al. Raajo iyo daaweyn dhab ah. 2010 Nov-Dec; 28 (6 Saynis 63): S71-7. Ciladda galmada iyo cytokines proinflammatory ee fibromyalgia syndrome.
Kumar A, et al. Wargeyska India ee farshaxanka. 2011 May; 43 (3): 324-9. Qalabka Nitric oxide ee difaaca ilaysiga daawooyinka antidepressant-ka ee ka hortagga cudurrada dabadheeraadka dabiiciga ah ee jiirarka.
Martin L. Pall, Iskuulka Khabiirada Molecular, Jaamicadda Gobolka Washington. All rights reserved "Cudurrada Cudurrada Cusub ayaa soo saarey sharraxaad loogu talagalay Kooxaha Cudurrada oo idil."
Meeus M, iyo al. Gudaha. 2010 Nov-Dec; 24 (6): 865-9. Nitric oxide-ka ayaa caadi ah oo aan la xiriirin heerka dhaqdhaqaaqa diiqada daba-dheeraaday: daraasad-koontaroolid kayska.
Morris G, Maes M. Cilmi-nafsiga neuropharmacology. 2014 Mar; 12 (2): 168-85. Niyadjabka Oxidative iyo Vitamin-ka iyo hababka difaaca jirka ee ku jira bukaanka qaba cudurka encephalomyelitis (ME) / cudurka dufanka daba-dheeraaday (CFS).
Sachdeva AK, Kuhad A, Chopra K. Warbixinta cilmi-baarista maskaxda. 2011 Oct 10; 86 (3-4): 165-72. Epigallocatechin gallate waxay sare u qaadaan akhlaaqda iyo isdabajarka biyoodka ee qaabka jiirarka ee cilladda dareenka daba-dheeraadka ah ee culus.
Sendur OF, et al. Caalami ah Rheumatology. 2009 Apr; 29 (6): 629-33. Serum antioxidants iyo heerarka nitric oxide ee fibromyalgia: daraasad la xakameeyey.
Suarez A, et al. Xayawaanka Caafimaadka Haweenka. 2010 Jun; 19 (6): 1073-7. Waxsoosaarka Nitric oxide metabolitiga inta lagu jiro jimicsiga ee diiqada daba-dheeraada: daraasad kiis-kumbuyuutar.