Isbedelka Hormoonku wuxuu suurtogal u noqon karaa dumarka halista sare leh ee HIV
Khatarta HIV-ga ayaa aad uga sareysa ragga ilaa dumarka marka loo eego haweenka ragga sababo badan oo ka mid ah nuglaanshaha dabada, ilmo-galeenka iyo (laga yaabo) ilmo-galeenka. Ma aha oo kaliya in uu jiro dusha sare ee xubinta taranka ee haweenka taranka haweenka (FRT) marka la barbardhigo guska, isbedelka bayoolojiga ayaa badanaa samayn kara unugyada mucosal ee line-ka FRT xitaa u nugul caabuqa.
Inkasta oo xuubka maqaarka ee hoosta haweenku ay ka sii badan yihiin malawadka, iyada oo qiyaastii diyaargarow dusha laga saaro unugyada epithelial ah oo bixinaya xanuunka ka hortagga infekshanka, HIV weli wali wuxuu heli karaa helitaanka jirka iyada oo loo marayo unugyo caafimaad qaba. Intaas waxaa sii dheer, ilmo-galeenka, kaas oo leh xuubo dheecaan leh oo ka yar hoosta xubinta taranka, ayaa lagu daboolaa CD4 + T-unugyada , unugyada difaaca jirka ee HIV-ga doorbidaya.
Waxyaabo badan ayaa kor u qaadi kara nuglaanta haweenka HIV, oo ay ka mid yihiin bakteeriyada vaginosis (taas oo bedeli karta flanka siilka) iyo unugyada afka ilmagaleenka (oo sidoo kale loo yaqaano "ilmo-xannuun" ilmo-galeenka).
Laakiin caddaynta sii kordheysa ayaa sidoo kale muujisay in isbeddellada hoormoonka, dabiiciga ah ee soo noqnoqonaya ama sababay, ay door muhiim ah ka ciyaaraan sii kordhinta suurtagalka haweenka ee HIV-ga.
Suuxdinta iyo Khatarta HIV
Daraasad cilmi baaris ah oo ka soo baxday cilmi baarayaal ka tirsan Jaamacadda Dartmouth ee Geisel School of Medicine ayaa soo jeedisay in isbeddelada hoormoonka inta lagu jiro caadada caadada u ah HIV-ga iyo cudurrada kale ee galmada la isugu gudbiyo (STIs) "daaqada fursada" si loo faafo.
Xaaladda difaaca jirka, labadaba (dabiiciga) iyo la qabsashada (ka dib markii la helay infekshin hore), waxaa loo yaqaanaa in lagu xakameeyo hormoonnada. Xilliga caadada, labada hormoodba waxay loola jeedaa in lagu wanaajiyo xaaladaha bacriminta iyo uurka-estradiol iyo progesterone -waxay saameyn ku yeeshaan unugyada epithelial, fibroblasts (unugyada laga helo unugyada isku xiran), iyo unugyada difaaca ee line-upka FRT.
Marka sidaas la yeelo, jawaab-celinta difaaca ayaa hoos u dhacda, khatarta helitaanka HIV-ga si weyn ayaa loo kordhiyaa.
Haddii la xaqiijiyo, daraasaddan ayaa laga yaabaa in ay ka caawiso sidii loo dardar-gelin lahaa hababka loo daweyn karo si kor loogu qaado waxqabadka ladagaallanka fayraska iyo / ama saamayn ku sameeya hababka galmada (sida, aqoonsashada waqtiyo nabadgelyo ah galmo) inta lagu jiro tan loo yaqaan "daaqada fursadda."
Halista menopause iyo HIV
Taa beddelkeeda, daraasad kale oo ka soo baxda 2015-ka Jaamacadda Pittsburgh Medical Center ayaa soo jeedisay in isbedelada FRT ay wax ka geysan karto khatarta sii kordheysa ee HIV ee haweenka ka dib.
Waxaa si wacan loo ogsoon yahay in habka difaaca ee unugyada hoose ee xubnaha taranka ay si dhaqso ah hoos u dhacaan inta lagu guda jiro iyo ka dib dhalmada, oo leh khafiifinta unugyada epithelial iyo hoos u dhaca calaacalaha xuubka. (Xuubka, oo loo yaqaan inuu ka kooban yahay nooc ka mid ah antimicrobials, waxaa lagu taageeraa dheecaan ka yimid FTR sare oo bixiya difaaca hoose ee hoosta taranka.)
Cilmi-baadhayaashu waxay qorayeen 165 haween ah asymptomatic-oo ay ku jiraan dumarka postmenopausal; dumarka horay haweenka uurka ku jira ma ahan kuwa ka hortagga uurka; iyo haweenka ku jira ka-hortagga uur-qaadista-iyo qiyaasta nugul HIV-ga iyada oo isbarbardhigaysa dareerayaasha afka ilmagaleenka ee laga helo waraabinta. Isticmaalka baaritaanada HIV-ga gaar ahaaneed, waxay ogaadeen in dumarka post-menopausal ay saddex jeer ka yar yihiin "dabiiciga ah" hawlaha HIV-ga (11% vs 34%) marka loo eego labada kooxood ee kale.
In kastoo gabagabeynta ay xadidan yihiin naqshadeynta iyo cabbirka daraasadda, waxay soo jeedinaysaa in isbedelada hoormoonka ee mudada ka dib iyo ka dib dhalmada ka dib ay gabdhaha da'da weyn ku dhejin karto khatarta sii kordheysa ee HIV. Sidaa darted, xooga la saaro waa in lagu meeleeyaa tacliinta galmada oo ammaan ah oo loogu talagalay haweenka da'da weyn, iyo sidoo kale xaqiijinta in HIV-ga iyo baaritaanyada kale ee STI-da aan la iska ilaalinin ama daahin.
Xanuunka Ka-hortagga Uurka iyo Xoogga HIV-ga
Caddeyn in hormoonnada hormoonnada hormoonnada ay kordhin karto khatarta HIV-ga ee haweenka ayaa ah mid aan ku habooneyn, ama hab daaweyn ah oo afka laga qaato ama la isku duro. Daraasad adag oo ku salaysan 12 daraasadood - siddeed wax lagu sameeyo dadweynaha iyo afar ka mid ah haweenka khatarta sare leh-waxay muujinayaan heer dhexdhexaad ah, kororka guud ee halista HIV ee haweenka iyadoo la adeegsanayo muddada dheer ee daawada medroxyprogesterone acetate (DPMA, aka Depo -Provera ).
Dumarka guud ahaan, khatarta ayaa loo arkaa inay yar tahay.
Falanqaynta, oo ay ku jiraan in ka badan 25,000 oo kaqeybgalayaal haween ah, ma muujin xiriir la taaban karo oo u dhexeeya uur-qaadidda afka iyo khatarta HIV.
Inkasta oo xogta loo arko inay tahay mid aan ku filnayn soo-jeedinta isticmaalka DPMA, cilmi-baarayaashu waxay ku talinayaan in haweenka isticmaala cirbadaha progestin-ka kaliya lagu ogaado hubin la'aanta DPMA iyo halista HIV, iyo in lagu dhiirrigeliyo inay isticmaalaan kondomka oo ay sahamiyaan istaraatiijiyad kale oo ka hortag ah sida Hore HIV-ga horey loo ogaado (PrEP ).
Ilaha:
> Chappell, C .; Isxaaq, C .; Xu, W .; et al. "Saamaynta Menopause oo ku saabsan Dhaqdhaqaaqa Horumarinta Antiviral ee Lacagta Cervicovaginal." Somali Journal of Obstetrics iyo Gynecology. March 20, 2015; DOI: http://dx.doi.org/10.1016/j.ajog.2015.03.045.
Ralph, L .; McCoy, S .; Shiu, K .; et al. "Isticmaalka Kontoroolka Hormonal iyo Khatarta Haweenka ee Hawlgabka HIV: Falanqaynta Qiimaynta ee Daraasaadka Muuqaalka." Lancet Cudurrada faafa. Janaayo 8, 2015; 15 (2): 181-189.
Wira, C .; Rodriguez-Garcia, M .; iyo Patel, M. "Doorka Xayawaanka Galmada ee Ilaalinta Difaaca ee Habka Badbaadinta Naaska." Astaamaha Dabeecadda . March 6, 2015; 15: 217-230.