Sidee Calaamadaha Lymphoma Caawiya ee Lagu yaqaano Lymphoma at Heerka Molecular
Waa maxay calaamadaha caleemaha lenfoma, ama calaamadaha CD? Waa maxay sababta ay muhiim u yihiin iyo sidee bay door uga ciyaaraan daaweynta lymphomas?
Muhiimadda Calaamadaha Lymphoma CD
Go'aaminta calaamadaha CD-da ee lymphomas waxay muhiim u tahay xulashada daaweynta ugu fiican ee cuduradan, laakiin had iyo jeer looma helin. Aan fiirino taariikhda si aan u fahamno muhiimada baaritaankaan lagu ogaanayo daaweynta ugu fiican ee kansarkaaga.
Waa maxay sababta Calaamadaha Lymphoma waa Muhiim
Isku day in aad qiyaasto hal nooc oo unugyo ah oo kiciya ilaa soddon nooc oo kansar ah - oo dhan oo leh hal magac. Qalabka lymphomas waxaa laga yaabaa inay kuugu jiraan qanjidhadaada, sida miisaankaaga maskaxdaada, sida cudurka calooshaada, ama sida xanuunada maqaarkaaga oo dhan. Maahan arrin meel uun ah - lymphoma laga helay mid ka mid ah meelahaas ayaa noqon kara mid ka mid ah noocyada badan. Doorashada daaweynta ugu fiican waxay ku xiran tahay ogaanshaha nooca gaarka ah.
Microscope ma ahan mid ku filan in lagu ogaado lymphomas
Xitaa labaatan sano oo dib u soo laabtay, waxa baaristu ku aragtay mashiinka yar yar ee la yiraahdo stains fudud wuxuu ahaa dhamaanteena aan ku ogaanay nooca lymphoma. Waxaana jiray dhowr nooc oo lymphoma ah oo keliya oo la kala saari karo. Si kastaba ha ahaatee, badanaa waxay u muuqatay in dabeecadda lamid ah ee nooca buuryada ay ka duwan tahay shakhsiyaadka kala duwan. Dhab ahaan, waxbaa ka maqnaa.
Maqaalku wuxuu ku jiraa Molecules
Maadaama daawadu ay ka soo wareegtay unugyada si loo siiyo meco, farsamooyin ayaa loo sameeyay si loo aqoonsado qaar ka mid ah astaamaha gaarka ah ee laga helay dusha sare ee unugyada.
Marka kuwan lagu daboolo unugyada lymphoma, arrimahaa waxay soo qaadeen isbedel dhab ah. Waxay soo baxday in qalabka lymfomasku aanu ahayn mid caan ah oo noocyo kala duwan ah, laakiin wax badan ayaa ka sii daraya.
Waa maxay calaamadaha CD-da Lymphoma?
On dusha sare ee lymphocytes, unugyada loo beddelo lymphomas, been sheega qaar ka mid ah molecules gaar ah.
Kuwaas waxaa loo magacaabay 'kala duwanaansho kooxeed' ama calaamadaha CD . Marka lymphocytes caadi ka soo baxdo unugyada cusub si unugyada baaluqa, calaamadahaas ayaa isbeddela. Waxaa la ogaadey in lymphomas oo horay u ekaatay mid la mid ah 'mikroscope' ay leedahay calaamado kala duwan oo dusha sare ah. Markii ay dhacdey, waxay u dhaqmeen sida cuduro kala duwan oo wadajir ah.
Calaamadaha Cudurka Lymphoma ee Calaamadaha
Maanta, calaamadaha lagu daaweeyo lymfoma si dhakhso ah uma dhicin illaa laba asalood oo lymfoma la aqoonsado. Si loo gooyo lymphoma gaar ah ee kooxda ku habboon, immunohistochemistry waxaa loo isticmaalaa si loo ogaado maadaddan qaaska ah ee unugyada shubista biopsy.
Hadda waxaannu haysannaa daawooyin gaar ah oo weeraraya unugyada CD-yada ee dusha sare ee unugyada lymphoma. Daawooyinkan - oo loo yaqaan 'antoclonal antibodies' - waa weeracyada kaliya ee leh calaamad gaar ah.
Tusaalooyin gaar ah ayaa ka dhigaya mid aad u fudud in la fahmo. Iyadoo lymphomas, way adkaan kartaa haddii aan suurtagal ahayn in la sheego farqiga u dhexeeya noocyada kansarka qaarkood. Qalabka lymphomasku waa unugyada unugyada unugyada B ah qaarna waa lakabomaha unugyada T, laakiin unugyada B iyo T unugyada waxay isla eegi karaan iskudhafka 'mikroskob'. Inkastoo ay isku egyihiin, kansarrada ku lug leh unugyadaas ayaa si kala duwan u dhaqmi kara waxayna u jawaabaan si kala duwan oo daawooyinka kala duwan.
CD20 waa calaamad ama antigen laga helay dusha sare ee unugyada B, laakiin ma aha unugyada T. Qalooji Lymphoma (DLBCL) - Kansarka unugyada B - wuxuu u egyahay mid isku mid ah unugyada weyn ee unugyada unugyada unugyada waaweyn - kansarka T-yada - hoosta mikroskoobka. Hase yeeshee, tijaabada immunohistochemistry, ayaa si kastaba ha ahaatee, waxay xaqiijin kartaa joogitaanka CD20 - antigen-ka laga helo unugyada B si loo xaqiijiyo in kansarku yahay DLBCL oo aan lafdhabarta unugyada waaweyn ee unugyada waaweyn. Qanjiraha unugyada waawayn ee unugyada waaweyn, waxaa lakala qaadi karaa jiritaanka CD30 antigen.
Calaamadaha Lymphoma ee Go'aaminta Daaweynta iyo Saadaalinta
Kama joogaan halkaas. Qaar ka mid ah calaamadaha gaarka ah (mid ka mid ah oo loo yaqaan bcl-2) ayaa xitaa u sheegi karaa dhakhtarka sida ugu wanaagsan ee uu cudurku u kici karo.
Qaar ka mid ah kuwa kale (sida CD20) ayaa tilmaamaya in daaweyn gaar ah ay shaqayn doonto. Tusaalooyinka calaamadaha CD ee lagu beegsanayo daaweynta lymphoma waxaa ka mid ah Rituxan (antibiotika) Rituxan (rituximab) kaas oo bartilmaameedsanaya antibiyootika CD20 dusha sare ee unugyada lymfoma qaarkood iyo sidoo kale unugyada lymphocytic leukemia.
Maadaama cilmi-baarisyo badan oo calaamadahan ah ay ku jiraan calaamadahaas, isticmaalada cusub ayaa soo baxaya wakhti kasta. Runtii, lymphoma ayaa soo gashay erey maadi ah.
Ilaha:
Machadka Kansarka Qaranka. Kalluumeyaal Tumor ah. La daabacay 11/04/15. http://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis/tumor-markers-fact-sheet