Taariikhda Dhibaatooyinka Dheeraadka Daroogada Dabiiciga ah
Ma aha qarsoodi ah in dabiiciga ah ee loo yaqaan 'tyroid drugs' (NDT) uu ahaa mid muran badan oo tobaneeyo sano ah. NDT waa nooc daawo oo loo yaqaan 'thyroid hormone' , waxaana sidoo kale loo yaqaan ' thyroid' dabiiciga ah , ka soo saarka tayroodhka, 'thyroid porcine', ama magac dabeecadeed sida 'Nature-throid or Armor Thyroid'.
NDT waxaa markii hore la soo celiyey horraantii 1900-yadii waxaana laga sameeyay qanjidhada qanjirada qallafsan ee xayawaanka, sida hab lagu daaweyn karo hypothyroidism, yaraanta hormoonka thyroid.
Noocyada ugu horreeya ee tayroodh dabiiciga ah ayaa ka yimid qanjirka thyroid ee lo'da, laakiin horraantii 1900-kii, shirkadda hilibka Armor-yada ayaa soo gashay beerta, suuq-geynta dabiiciga ah ee dabiiciga ah ee loo yaqaan "Thyroid Throid".
Sababtoo ah waxaa la horumariyay ka hor FDA, waxay sharci ahaan u tahay daawo rijeeto ah oo lagu dammaanad qaaday, iyo dabiiciga dabiiciga ah ee loo yaqaan 'thyroid', iyada oo ay maamusho FDA, waligeed ma aysan marin habka ' Nidaamka Cusbaha Daroogada ' (NDA) ee looga baahan yahay daroogooyinka cusub soo bandhigay suuqa ka dib markii FDA la aasaasay.
Qanjirada dabiiciga ah ee dabiiciga ah waxaa ku jira T4 (thyroxine) iyo T3 (triiodotyronine), iyo sidoo kale calcitonin, iyo walxo kale oo laga helo qanjirada dabiiciga ah . Qanjirka 'thyroid' caadiga ah wuxuu soo saaraa ugu horreyn T4 (hormoonka xajinta) iyo qaar ka mid ah T3, iyo T4 waxaa loo beddelaa T3, hormoonka firfircoon, si loogu isticmaalo unugyada iyo unugyada jidhka.
Rise of Synthroid
Intii lagu jiray bartamihii qarnigii ugu danbeeyay, daawada dheef-shiid kiimikaadka ayaa ka yimid suuqa.
Noockani waxa uu ka kooban yahay hormoonka T4-ga, oo loo yaqaan 'levothyroxine', oo mararka qaarkood loo yaqaan magac caanka ah, Synthroid. Levothyroxine ayaa noqday mid sii caan ah, iyo qeybtii labaad ee qarnigii 20aad, waxa ay noqotay daaweynta xulashada bulshada caafimaadka guud.
Dhakhaatiirtu waxay sheegteen in ay tahay mid xasilloon oo ka badan tan dabiiciga ah ee loo yaqaan 'thyroid', iyo in jidhku awooday inuu T4 u beddelo T3 firfircoon oo loo baahan yahay si loo xalliyo hypothyroidism.
Mudo sanado ah, tirada ugu badan ee bukaan-socodka thyroid-ka waxaa loo qoray daawooyinka levothyroxin si loo daaweeyo hypothyroidism. Hase yeeshee, markii xiisaha uu ku sii kordhay daawada dabiiciga ah ee 1980-yadii, dhakhaatiirta is-dhexgalka iyo kuwa xeel-dheerka ah ayaa bilaabay inay dib u qoraan tafaasiga dabiiciga ah ee dabiiciga ah, oo ku sii jiray suuqa, in kasta oo ay la wadaagaan suuq yar.
Qaar ka mid ah dhakhaatiirta waayeelka ah ee horay u isticmaali jiray dabeecada dabiiciga ah ee dabiiciga ah ee bukaankooda, waxay bedesheen bukaanjiifka qaar dib ugu laabtay daroogooyinka dabiiciga ah ee loo yaqaan 'tyroid drugs' Qaar ka mid ah bukaankan ayaa ka cabanaya, ka dib markii loo beddelay levothyroxine, in ciladahoodu sii xumaatay ama aan la xalin karin .
Inkasta oo bukaannada tirakoobka badan iyo dhakhaatiirtu ayan wali ogeyn in ay jiraan fursado ka baxsan levothyroxin si loo daaweeyo hypothyroidism, 1990-maadkii, wacyigelinta NDT sida ikhtiyaarka oo kordhay, sababo badan:
- kor u qaadka Internetka
- korodhka bukaanka ee bukaanka kale
- kordhinta wadaagida xogta bukaanka iyo takhaatiirta
Badanaa, bukaannada tirakoobka iyo qanacsanaan la'aanta ee qaata barashada levothyroxin waxay ogaadeen in daawooyinka dabiiciga ah ee dabiiciga ah ee loo yaqaan 'thyroid derivatives' ay bedel u yihiin levothyroxin.
Isticmaalka daroogooyinkan ayaa kordhay, iyo bukaanjiifka qaarkood waxay ogaadeen in astaamahooda iyo heerka dhiigga ee tirakoobka , ay si fiican u xakamaynayaan dabeecada dabiiciga ah ee loo yaqaan 'thyroid', marka la barbardhigo levothyroxine, ama xitaa levothyroxine oo lagu daray qaabka synthetic ee T3 (magaca calaamadiisu waa Cytomel, iyo guud ahaan waxaa loo yaqaan liothyronin.)
Khilaafka ayaa sii kordhay iyadoo bukaanno badani waydiisteen dabeecadda dabiiciga ah ee dabiiciga ah, iyo xirfadleeyaal badan, gaar ahaan kuwa leh diiradda saameeynta badan, waxay ku qorantahay. Cilmi-xumada ayaa ku badatay, iyada oo dhakhaatiirta qaarkood ay si khalad ah u sheegteen in daawooyinka dabiiciga ah ee dabiiciga ah la heli karo iyada oo aan la soo qorin ama laga sameeyey lo'da, sidaas darteedna waxay halis u yihiin.
Tilmaamaha daaweynta rasmiga ah ayaa kugula taliyay in la qaato levothyroxine oo si khaas ah loogu niyadjabey isticmaalka daroogooyinka dabiiciga ah ee la daboolay.
Hase yeeshee, sida bukaanka awoodda iyo aqoonta ayaa kordhay, iyo dawooyinka kale ee caadiga ah iyo kuwa kale ayaa kor u kacay, tirada dawooyinka ee daawooyinka tayroodh dabiiciga ah ayaa kordhay. Shaybaarka, Galbeedka Cilmi-baarista, oo sameeyey dabiiciyaasha dabiiciga ah ee qallafsan Nature-throid iyo Westhroid (hadda WP Thyroid), waxaa laga iibsaday RLC Labs, labadan daweed waxay heleen saamiyo badan oo suuqa.
Tilmaamaha Hawl-qabadka ee ugu dambeeyay ee loogu talagalay Hypothyroidism ee dadka waaweyn , oo ay daabacday Ururka Mareykanka ee Clinical Endocrinologists (AACE) iyo American Thyroid Association (ATA), ayaa si qaldan u qeexday tayroodh dabiiciga ah. Dhibaatooyinka ku saabsan doodaha Tilmaamaha ee tirtirga dabiiciga ah ayaa lagu soo koobay maqaalkan, laakiin asal ahaan, waxay sii wadeen inay si qalad ah u soo jeediyaan in daawooyinka NDT ay ka soo baxaan lo'da, waxayna isku dayeen inay xiraan mawduuca iyaga oo leh "Ma jirto wax caddayn ah oo lagu taageerayo isticmaalka qanjidhada qallafsan hoormoonka oo doorbidaya daawada L-thyroxine monotherapy ee lagu daaweynayo hypothyroidism sidaas darteedna loo naqshadeeyo hoormoonka tayroodhka waa in aan loo isticmaalin daaweynta hypothyroidism. "
Waxay ku fashileen in aysan jirin wax caddeymo ah oo lagu taageerayo isticmaalka levothyroxine ee doorbididda dabiiciga ah ee dabiiciga ah. Cilmi-baaristu si uun ugama aysan samayn, sidaas darteed sannado caado, diinta, iyo suuq-geynta ayaa u muuqda inay yihiin xoogagga darawaliinta ka dambeeya talooyinkooda, ma helin natiijooyin indho-furan, dib-u-eegis, joornaal cilmi baaris lagu daabacay.
Isbarbar dhigista Levothyroxine ilaa dabiiciga ah ee loo yaqaan 'Thyroid Desiccated'
Daraasad cusub oo la kala soocay, laba-indhoole ah, daraasad isgaadhsiin ah oo la barbardhigay qanjidhka dabiiciga ah ee loo yaqaan 'tirothyroxine'. Daraasadu waxay qiimaysay 70 bukaan (oo da'doodu u dhaxayso 18 ilaa 65 sano) oo qaada cudurka hypothyroidism . Bukaannada ayaa si aan kala sooc lahayn loogu qoondeeyey labadii toddobaad ee la soo dhaafay ee loo yaqaan 'thyroid' ama levothyroxine.
Dhamaan daraasaddan, bukaanka ayaa la weydiiyay cidda ay doorbidayaan, qiyaastii 49 boqolkiiba waxay doorbidayaan qanjirada dabiiciga ah ee dabiiciga ah, iyo qiyaastii boqolkiiba 19 kuwaasoo ka doorbiday levothyroxin. Qiyaastii boqolkiiba 33 ma aysan sheegin doorasho. Bukaannada qaata dabeecadda dabiiciga ah ee loo yaqaan 'thyroid' ayaa lumay saddex rodol, marka loo barbar dhigo bukaanka qaadaya levothyroxine , oo aan lumin miisaanka.
Cilmi-baaristaan waxaa loo soo bandhigey Ururka Endocrine ; bukaansocodka weyn ee muhiimka ah. Bukaanka iyo takhaatiirta waxay xaq u leeyihiin in ay qoraan oo ay qaataan nooca ama nooca daaweynta hormoonada hormoon ee hormoonnada ah si ammaan ah u shaqeynaya oo ugu fiican bukaan kasta.
Ereyga ka
Haddii aad xiiseyneysid baaritaanka NDT sidii daweyn loogu talagalay hypothyroidism, maskaxda ku hay:
- Waxaa laga yaabaa inaad u baahatid inaad la shaqeysid takhtar isku dhafan ama dhajis ah, oo ka soo horjeeda cilmi-baarista endocriniga.
- Waa inaad la shaqeysaa dhakhtar leh khibrad u leh qorista NDT, iyo maareynta bukaanka NDT.
- Marna ma aha fikrad fiican inaad ka iibsato dawooyinka dhakhtarku qoro, iyada oo aan dawo laguu qorin, laguna qaadan iyada oo aan la socon kormeeraha dhakhtarka.
- Daawooyinka dheeraadka ah ee qanjirka 'thyroid' ee dheeraadka ah ee takoorka ah maaha kuwa loo yaqaan 'NDT', maaha beddel daawo beddelaadda hoormoonka tayroodhka.
> Ilo:
> Hoang TD. "Tijaabada tayroodhka ee loo yaqaan" tetothyroxine "marka la barbar dhigo daaweynta hypothyroidism." Ururka Astaamaha Maraykanka (March, 2013).