Technivie ( ombitansvir + paritaprevir + ritonavir) waa daroogo isku dhafan oo loo isticmaalo daaweynta infakshanka cagaarshow C (HCV) ee joogtada ah. Saddexda wakiil oo ka kooban Technivie ayaa sidoo kale lagu soo wareejiyay daaweynta HCV ee labada kiniin ah, Viekira Pak .
Technivie waxaa la ansixiyey July 24, 2015 by Maamulka Cuntada iyo Dawooyinka ee Maraykanka (FDA) si loogu isticmaalo dadka waaweyn 18 sano ama ka weyn HCV genotype 4 infekshanka (GT4) oo aan lahayn cirrhosis .
Technivie waa daaweynta HCV oo bilaash ah, dhammaan af-af iyo af-la'aan ah oo loogu talagalay bukaanada GT4 infekshanka HCV ee daba-dheer, dadka dhaqan ahaan loo arko inay adag tahay in la daaweeyo.
Technivie ayaa lagu soo warramey in ay leedahay daaweyn 100% oo aan hore loo daaweyn ("daaweyn nal") ee tijaabada wajiga IIb ee la qabtay laga bilaabo Agoosto 12, 2012 ilaa November 19, 2013.
Qiyaasta
Labo kiniin (12.5mg ombitasvir, 75mg paritaprevir, 50mg ritonavir) ayaa maalin kasta la qaataa cunto aan u baahnayn cunto dufan ama kaloric ah. Kiniiniyada Technivie waa casaan, qallafsan iyo filim qaboojiye ah, oo leh "AV1" oo ka kooban hal dhinac.
Soo-jeedinta Talooyinka
Technivie waxaa lagu qoraa koorso 12 asbuuc ah oo ay la socoto ribavirin (daroogo loo isticmaalo in lagu xakameeyo fayruska RNA). Qiyaasta lagu taliyey ee ribavirin waxay ku salaysan tahay miisaanka, sida soo socota:
- In ka yar 165 rodol (75kg): 1000mg maalin kasta, oo loo kala qaybiyo laba jeer maalin walba cunto
- 165 rodol (75kg) iyo in ka badan: 1250mg maalin kasta, oo loo kala qaybiyo laba jeer maalintii cunto
Kooraska 12-usbuuc ee Technivie ayaa loo tixgelin karaa daaweynta na soo marin kara bukaanka aan awoodin inuu u dulqaado ribavirin.
Saameynada Caadiga ah
Waxyeellooyinka ugu badan ee la xidhiidha isticmaalka Technivie (oo ku dhacda ugu yaraan 7% bukaanada) waa:
- Jilicsanaanta jirka
- Daal
- Lalabbo
- Insomnia
- Finan
Daawooyinka Lagu Hayo
Daawooyinka soo socda waa in aan la qaadin marka la isticmaalayo Technivie:
- Anticonvulsants: Tegretol, Dilantin, Trileptal, phenobarbital
- Ciladaha dhimirka: Orap
- Dawada Antiretroviral: Sustiva
- Daroogooyinka hoos u dhigi kara daroogooyinka: Altoprev, Mevacor, Zocor
- Daawada aan kala go 'lahayn: Revatio
- Ergot Wicitaanada (oo loo isticmaalo daaweynta madax xanuun): DHE 45, Ergomar, Ergotrate, Hydergine, Migranal
- Estinyl estradiol-ka kooban uur qaadista: Estinyl, Apri, Reclipsen, Azurette, Kariva, Yaz, Yasmin, Ocella, Vestura, Beyaz, Safiral, Zovia, Demulen, Demulen 1/35, Kelnor 1/35, Nuva Ring, FaLessa, Lutera, Alesse , Orange, Aviane, Ortho Evra, Xulane, Lo Loirin Fe, Necon 1/35, Minastrin 24 Fe, Loestrin 24 Fe, Ortho Tri-Cyclen, Sprintec, Ortho Tri-Cyclen Lo, Tri-Sprintec, Cryselle, Lo / Ovral, Ovral, Elinest
- Dawooyinka anti-tuberculosis ku salaysan Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Sedatives: Calaamadaha, Halcion
- St. John Wort
Khilaafaadka iyo Tixgelinnada
Technivie laguma talineynin bukaanka qaba naafanimada dhexdhexaadka ah (Child-Pugh score B) oo ka horjeeda bukaanka qaba naafonimada daran ee ciyaalka (Cunug-Pugh score C).
Technivie ayaa ka hortageysa isticmaalka bukaanada qaba cilad xumada loo yaqaan ' ritonavir' (ie, kuwaas oo la kulmay Stevens-Johnson Syndrome ama sunta sunta ah ee sunta).
Inkasta oo Technivie lafteedu aysan ka hor istaagin isticmaalka uurka, isku dhafka Technivie iyo ribavirin waa in aan loo isticmaalin dumarka uurka leh ama ragga la shaqeeya dumarka uurka leh. Marka la eego naas-nuujinta, ma jirin wax muujinaya qoraalka horumarka aan caadiga ahayn ee daraasadaha xayawaanka; la-talin takhasus ah ayaa lagula talinayaa in laga wada hadlo faa'iidooyinka iyo saameynta xun ee naas-nuujinta inta uu ku jiro Technivie.
Xigasho:
Maamulka Cuntada iyo Dawooyinka Maraykanka (FDA). "FDA waxay ansixisay Technivie si loogu daaweeyo cagaarshowga C ee daba-dheeraaday genotype 4." Silver Spring, Maryland; saxaafadeed ay soo saareen July 24, 2015.
Hézode, C .; Asselah, T .; Reddy, R .; et al. "Ombitasvir oo lagu daray paritaprevir oo lagu daray ritonavir oo leh ama aan lahayn ribavirin ee bukaanada daaweynta-daaweynta iyo daaweyn-khibrad leh oo leh cirbad fayruska cagaarshowga C ee daba-dheeraaday (PEARL-I): tijaabin kala duwan, Lancet. Juun 20, 2015; 384 (9986): 2502-2509.