Qeybinta
Viekira Pak waa isku-dar daroogada loo isticmaalo si loo daaweeyo cudurka Cagaarshowga C ee daba-dheeraaday (HCV) . Baakada waxaa ku jira hal daroogo oo loo isticmaalo daawada Tiknoolajiyada (ombitasvir + paritaprevir + ritonavir) oo lagu duubo daawada daroogada.
Qaybaha daroogada ee ombitasvir, paritaprevir iyo dasabuvir waa antivirals (DHAs) oo toos ah oo fara-geliya fara-galinta fayraska.
Ritonavir daroogada, oo badanaa loo isticmaalo daaweynta HIV , ayaa lagu daraa inay kordhiso heerarka daroogada ee paritaprevir.
Viekira Pak waa inta badan, hase yeeshee had iyo jeer maaha, la wadaago ribavirin loomana baahna in lala qaato interferon pegylated (peg-interferon).
Viekira Pak waxaa la ansaxiyey December 19, 2014 by Maamulka Mareykanka ee Cuntada iyo Maandooriyaha (FDA) si loogu isticmaalo dadka qaangaarka ah 18 sano ama ka weyn HCV genotypes 1 infekshanka, oo ay ku jiraan kuwa qaba cirrhosis compensations (oo ah beerka ayaa wali shaqeeya) iyo qalabka beerka. Bukaanka qaba cirrhosis, Viekira Pak laguma talinayo.
Viekira Pak ayaa lagu soo waramayaa in ay leedahay 95% ama in ka badan, iyada oo keliya 2% bukaannada joojiya daaweynta sababtoo ah dulqaad la'aan. Waxaa haboon in la isticmaalo bukaanada qaba HIV / HCV oo wadaag ah .
Qiyaasta
Laba kiniin oo kiniin ah oo isku-dhafan oo lagu magacaabo ombitasvir + paritaprevir + ritonavir (25mg / 150mg / 100mg) ayaa maalin kasta la qaataa raashin, oo lagu daray hal miis ah dasabuvir maalinkiiba laba jeer subaxdii iyo fiidkii oo cunto ah.
Kiniiniyadu waxay ku yimaadaan si ku haboon oo loo qaato qiyaasta maalinlaha ah, oo leh tilmaamo daaweyn ah oo lagu daray sanduuq kasta. Kiniinka la isku-qaabeeyey ayaa ah casaan, filim iyo daboolay "AV1", halka kiniinka dasabuvir uu yahay mid furan, filim qaboojiye ah oo la duubay "AV2".
Soo-jeedinta Talooyinka
Viekira Pak ayaa lagu qoraa koorso 12 ilaa 24 toddobaad ah, sida soo socota talooyinka soo socda:
- Genotype 1a oo aan lahayn cirrhosis: Viekira Pak oo leh ribavirin 12 toddobaad
- Genotype 1a oo leh cirrhosis: Viekira Pak oo leh ribavirin muddo 24 toddobaad ah
- Genotype 1b oo aan lahayn cirrhosis: Viekira Pak keligeed 12 asbuuc
- Genotype 1b oo aan lahayn cirrhosis: Viekira Pak oo leh ribavirin muddo 24 toddobaad ah
Bukaan-socodka beerka ku-meel-gaadhka ah, Viekira Pak ayaa la qaadi karaa ribavirin muddo 24 toddobaad ah haddii hawlaha beerka (beerka) ay caadi yihiin oo fibrosis (nabar) waa yar yahay.
Saameynada Caadiga ah
Waxyeellooyinka ugu badan ee la xiriira isticmaalka Viekira Pak (oo ku dhacaya ilaa 10% bukaanada) waa:
- Daal
- Lalabbo
- Maqaarka cuncunka
- Dareen-celinta maqaarka
- Insomnia
- Tabar darri iyo daal
Isdhexgalka daroogada
Kuwa soo socda waa in laga fogaadaa marka la isticmaalayo Viekira Pak:
- Anticonvulsants: carbamazepine, phenytoin, phenobarbital
- Antihyperlipidemics (loo isticmaalo si loo yareeyo heerarka dhiigga ee dhiigga ku jira): geedkafibrozil
- Daawada ka hortagga miyir la'aanta: pimozide
- Daawada shuban-hoos u-dhaca: lovastatin, simvastatin
- Daawooyinka aan kala go 'lahayn: Viagra (sildenafil)
- Daawada Ergot-ku jirta (oo loo isticmaalo daaweynta madax xanuun iyo murgacasho): ergotamine, dihydroergotamine, ergonovine, methylergonovine
- Ethanyl estradiol (nooc ka kooban qaab milatari ah)
- Dawada HIV : Sustiva (efavirenz) , Atripla (efavirenz + tenofovir + emtricitabine)
- Daaweynta qotodheerta: alfuzosin
- Dawooyinka anti-tuberculosis ku salaysan Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Sedatives: Triazolam, midazolam afka
Khilaafaadka iyo Tixgelinnada
Bukaanka qaba xanuunka beerka dhexdhexaad ah, Viekira Pak laguma talinayo. Viekira Pak ayaa ka hortageysa isticmaalka bukaanada qaba xanuunka daran ee cagaarshow.
Viekira Pak ayaa sidoo kale ka hortageysa isticmaalka bukaan-socodka iyada oo loo yaqaanno "hypertice" oo loo yaqaan "ritonavir" (oo ay ku jirto Stevens-Johnson Syndrome, oo ah nolol khatar ah, fal-celin jidhka oo dhan).
Viekira Pak ayaa ka hortageysa isticmaalka dumarka uurka leh marka loo isticmaalo ribavirin.
Waxaa lagu talinayaa in dhammaan haweenka ku jira da'da ilmo-dhalista la kormeero bil kasta uurka inta lagu jiro muddada daaweynta. Waxaa sidoo kale lagu talinayaa in bukaanka iyo ragga ragga ah la siiyo ugu yaraan laba hab-hormoon oo aan ahayn hormoon ka hortag, iyo in loo isticmaalo muddada daaweynta iyo lix bilood kadib.
Xigasho:
Maamulka Cuntada iyo Dawooyinka Maraykanka (FDA). "FDA waxay oggolaatay Viekira Pak si loo daaweeyo cagaarshow C." Silver Spring, Maryland; saxaafadeed ay soo saartay December 19, 2014.