Daaweynta Antibiyootiggu ma waxtar u leedahay Rheumatoid Arthritis?
Taariikhda Raadinta iyo Sababta
Iyadoo aan la ogaan karin daaweynta in ka badan 100 nooc oo arthritis ah , daaweynta iyo la qabsashada calaamadaha xanuunka ayaa noqda kuwa ugu muhiimsan ee bukaanka iyo takhaatiirta. Sanadkii 1930-kii, bakteeriyadu waxay sababtay rheumatoid arthritis-ka , laakiin cilmi-baaristu waxay ahayd mid gaaban oo aan ka ahayn xaalado kala duwan oo ah cudur- wareer ama faleebo faleebo leh .
Sannadkii 1939, hogaanka dhabta ah ee dhabta ah ee ku saabsan cudurkan faafa ee rheumatoid arthritis ayaa kacday markii ay mycoplasma, bakteeriyadii fayruska ah ee nooca fayruuska ah, oo laga soocay qallajis iyo unugyada bukaanka rheumatic ah. Baarayaasha ayaa horey u muujiyay in mycoplasmas ay keento arthritis-ka jiirarka, jiirka, digaagga, riyaha, iyo lo'da. Waxay ka heleen mycoplasma xayndaabka genitourinary ee aadanaha, gaar ahaan dumarka.
Sannadkii 1949-kii Golaha Caalamiga ah ee Rheumatiska Cudurada ayaa suurtogal ah in xiriirka suurtogalka ah ee u dhexeeya mycoplasmas iyo cudurrada wadajirka ah la soo sheegay. Ka dib markii uu helay mid ka mid ah deeqda cilmi-baarista qaran ee ugu horreysay 1950-kii, Thomas McPherson Brown, MD iyo asxaabteeda ka tirsan qaybta cilmi-baarista arthritis-ka ayaa sannadkan soo sheegay in habka cudurka rheumatoidku uu ka badan yahay fal-celinta jirka ee antigen iyo antibio ( oo leh mycoplasma sida antigaa looga shakisan yahay) halkii laga heli lahaa noocyada faafa ee laysku qaadsiiyo.
Sanadkii 1955, qaybta cilmi-baadhista waxay sheegtey in mycoplasma, oo ka duwan bakteeriyada iyo fayrasku ku noolaan karaan dhaqamada unugyada unugyada iyaga oo aan burburin unugyada unugyada. Si loo sii xoojiyo mycoplasmas sida wakiil daroogo / antigen, sannadkii 1964 dhacdooyinka sare ee unugyada mycoplasma ee dhiigga ee bukaanada rheumatoid arthritis iyo bukaanka lupus ayaa la helay, oo tilmaamaya caabuq hadda ama hore.
Waxa kale oo la aqoonsaday inuu ahaa 4: 1 oo ka sarreeya cudurrada unugyada mycoplasma ee dheddigga oo tilmaamaya isku xirnaansho sare ee rheumatoid arthritis ee dheddigga.
Daaweynta Antibiyootigga
Dadaallada lagu muujinayo waxtarka daaweynta tetracycline ayaa la bilaabay waxaana ugu horreyntii soo sheegey in ka badan 40 sano ka hor Thomas McPherson Brown, MD. Laba todobaad ka dib geeridii Brown ee 1989-kii, NIH waxay codsatay codsiyada deeqda ee tijaabooyinka bukaan socodka daaweynta tetracycline ee loogu talagalay rheumatoid arthritis kaas oo uu raadinayay. Natiijooyinka hordhaca ah ee tijaabooyinka kiliinikada, oo hadda loo yaqaan MIRA ama Minocycline ee Rheumatoid Arthritis, ayaa rajo ka muujiyay, NIH waxay dalbatay codsiyada deeqda ah ee baaritaanka mycoplasma iyo siyaabaha kale ee faafa ee sababa cudurada roodhaydhka ee 1993, iyo daraasad tijaabo ah oo loogu talagalay antibiyootika xididdada rheumatoid arthritis ee 1994.
Natiijada ka soo baxda maxkamadaynta MIRA ayaa sheegtay, "Bukaanka qaba cudurrada fudud iyo tan dhexdhexaadka ah ee RA hadda waxay leeyihiin doorasho dal kale oo daweyn ah, mana aha oo kaliya antibiyootigga si yar ayaa loo yareeyaa calaamadaha, laakiin saamaynta daawadu waxay ahayd mid aad u yar oo aan ka yareyn inta badan lagu arkay inta badan kuwa kale daaweynta rheumatoidka. "
"Sababtoo ah Arthritis?"
Sanadaha oo dhan, fikradaha diirada saaraya mycoplasma oo ah wakiilka masuulka ka ah cudurada iyo tetracycline maaddaama daaweynta antibiyootigga ah ee doorashadu ay caqabad ku noqotay iyada oo aan haysanin lacag maaliyadeed oo ku filan cilmi baaris dheeraad ah iyo siyaasadeed.
"Sababtoo ah Arthritis?" by Harold W. Clark, Ph.D., mid ka mid ah jalayaashii Brown, waxay qiimeeyaan cudurrada rheumatoidka, tobanaan sano oo cilmi-baaris ah, raadinta daaweyn, iyo niyad-jabka dadka cilmi-baadhayaasha ah ee kiisaska daaweynta anti-mykoplasma-ka lagu joojiyay 40 sano dawladaha iyo ururrada arthritis ee kala duwan. Clark ayaa aaminsan in dadaallada la joojiyay sababtoo ah daweyn ammaan ah oo sahlan ayaa halis gelinaysa xarumaha caafimaad sababtoo ah bukaannadu waxay u baahan yihiin faragalin caafimaad oo yar.
Dhakhaatiir badan ayaa walwal ku ah shaki iigana wali ha soo jeedin daawada antibiyootikada bukaankooda. Arthritis Foundation waxay u muuqatay mid aan la xakameynin xitaa ka dib markii daaweynta antibiyootigga loo arko inay tahay mid ammaan ah oo hufan.
Agaasimaha caafimaadka ee caafimaadka ayaa lagu soo waramey in uusan u arkin daaweynta sidii mid weyn oo cilmi baaris ah oo ku saabsan isticmaalka qiyaasta iyo isticmaalka muddada dheer ee minocyclin loo baahan yahay.
Sida laga soo xigtay College College of Rheumatology, "Minocycline waxaa loogu talagalay bukaanka qaba calaamadaha rheumatoid arthritis-ka fudud, mararka qaarkood waxaa lagu daraa daawooyin kale si loogu daweeyo bukaanka qaba calaamadaha aan caadiga ahayn ee arthritis-ka."
Ilaha:
Waa maxay sababta xanuunka loo yaqaan 'Arthritis'? Raadinta Cause iyo Daawada Rheumatoid Arthritis, by Harold W. Clark, Ph.D., 1997
Cannon, Michael. Minocycline (Minocin). Kulliyadda Maraykanka ee Rheumatology. La daabacay March 2015.