Iskaashatada Daroogada Khatarta ah, Fahamsan
Haddii aad qaadatid daawo daweyn ah si loo daaweeyo kolestaroolka sare, taas oo kuxiran midka laguu qoray, dhakhtarkaaga ama farmashiistaha ayaa laga yaabaa in uu xooga saaro in aadan cunin raashin ama cabitaan casiir ah markaad ku jirto daroogada. Inkastoo laga yaabo inay u muuqato si qaas ah - sababtoo ah ma cabitaanka casiir ama liin-waxaa jira sabab aad u fiican oo loola jeedo cadawgaas gaar ah.
Gawracatadu waxay dhexgalaan waxyaabo kale oo siyaabo ah oo ka dhigi kara daawada wax yar oo waxtar leh iyo xitaa waxay keeni kartaa waxyeelo aan loo baahnayn.
Sababta loo yaqaan "Grapefruit and Statins" Ha isku qasin
Dhakhaatiirta, Statins waxaa loo yaqaan 'HMG-CoA reductase inhibitors', ereyga oo sharraxaya sida ay u shaqeeyaan hoos u dhigida heerarka kolesteroolka - iyadoo xannibaysa enzym taasoo fure u ah wax soo saarka kolestaroolka jirka oo lagu magacaabo HMG Co-A reductase. Statins waa daaweynta loo isticmaalo kolestaroolka ugu badan ee loo yaqaan 'cholesterol' sababtoo ah, marka lagu daro joojinta kolestaroolka, waxay saameyn ku yeeshaan qayb kasta oo ka mid ah astaamahaaga lipid (lipoproteins hooseeya, ama LDL , lipoproteins-ka sare, ama HDL iyo triglycerides ) hab wanaagsan .
Grapefruit wuxuu ka kooban yahay bergamottin kaas oo la falgalaya nidaamyo dhowr ah oo ku jira jidhka, oo ay ku jiraan cytochrome P-450 iyo P-glycoprotein. Nidaamyada enzyme waxay mas'uul ka yihiin in la jebiyo statins (iyo daroogooyinka kale) kiimikooyinka jidhku si fudud u isticmaali karo.
Haddii aad cuntid xayawaan ama cabitaan cabitaan ah marka aad qaadanaysid dawada, bergamottin waxay ka hortagi kartaa nidaamyadaas enzymes oo ka jajabinaya daroogada. Natiijo ahaan, waxay ku ururi kartaa qadaro badan oo jirkaaga ah.
Qaadashada alaabooyinka waxay noqon kartaa mid halis ah, taasoo keeni karta dhibaatooyin caafimaad sida maqaar cayilan oo dheellitiran ama xaalad dhif ah oo loo yaqaanno "rhabdomyolysis" kaas oo ka soo baxa muruqyada muruqyada, oo ku sii deynaya muruqyada muruqyada dhiigga kaasoo waxyeeleyn kara kelyaha iyo xataa keena dhaawac kelyaha ah.
Dhammaan mawaadiicda aan ku habboonayn waa kuwa aan ku haboonayn, laakiin kuwa ay yihiin, waxaa ka mid ah:
- Lipitor (atorvastatin)
- Mevacor (lovastatin)
- Zocor (simvastatin)
Statinska kale laguma muujin in ay yihiin dhibaato sida marka la isku daro dufanka. Cilmi-baadhayaashu waxay u maleynayaan inay taasi noqon karto sababtoo ah iyaga oo aan la jajabinin nidaamyada la midka ah ee enzymigga ah ee metabolize daroogada. Waxaa ka mid ah:
- Crestor (rosuvastatin)
- Pravachol (pravastatin)
- Lesco (fluvastatin)
- Livalo (pitavastatin)
Xitaa Juice yar ayaa laga yaabaa in ay badan tahay
Daraasado badan ayaa muujiyay in ay qaadato hal kaliya 4-wiqiyadood oo casiir ah, ama mid cusub oo lagu dubo, si ay u keento statins inay ku ururiso jirka. Sidaa darteed, haddii aad qaadatid Lipitor, Mevacor, ama Zocor waxa ugu wanaagsan inaad si fiican u xakameyso xayawaan badeedka. Haddii aad si dhab ah u jeceshahay diyaarsanaanta oo aad neceb tahay fekerka ah inaad bixiso, la hadal bixiyahaaga daryeelka caafimaadka adigoo ku beddelaya xaalad kale ama ugu yaraan hoos u dhigista qiyaasta aad qaadatid. Habkaas, waxaad ku raaxeysan doontaa inaad ku raaxeysatid cawskaaga oo aadan ku dhibin saameynta xun ee ay qaadato. Waxay xitaa noqon kartaa fikrad wanaagsan inaad ka taxadartid haddii aad qaadatid xayawaan kale oo aanad isticmaaleynin xayawaanka dhowr saacadood ka hor ama ka dib qaadashada dawadan.
> Ilo:
> Dipiro JT, Talbert RL. Farmashoterapi: Habka Pathophysiological , 9th ed 2014.
> Lee JW, Morris JK, Wald NJ, et al. "" Casiirada "iyo" Statins ". Am J Med 2016; 129: 26-29.
> Vaquero MP, Sanchez Muniz FJ, Redondo SJ iyo al. "Isdhaafsashada Cunto-daroogada Aasaasiga ah ee Saameeya Noocyada Kineticka iyo Qaybaha Hypolipidaemic ee Statins." Nutr Hosp 2010; 25: 193-206.