Juxtapid (lomitapide) waa daawo loo isticmaalo in badanaa la yareeyo heerarka guud ee kolestaroolka, LDL, iyo heerarka apolipoprotein B - oo ay weheliyaan cunto iyo daaweyno kale - shaqsiyaadka leh xannuunada macaan ee familial hypercholesterolemia , xaalad naadir ah, dhaxal ah oo keena heerarka sare ee LDL kolesteroolka iyo wadnaha cudurka horey u soo noolaanaya. Juxtapid ayaa loo ansixiyey isticmaalka Maraykanka ee Hay'adda Cuntada iyo Maandooriyeyaasha bishii December 2012.
Juxtapid waxa kaliya oo lagu bartaa dadka lagu sheegay cudurka macaanka ee "hypercholesterolemia" - oo aan ahayn shakhsiyaadka qaba xaalado kale oo keena heerarka kolestaroolka sare. Mid ka mid ah daraasadda, Juxtapid 5 illaa 60 mg maalin walba waxaa la siiyay shakhsiyaad horay u qaata daaweyn kale oo baruurta ah oo hoos u dhigaya heerarka sare ee kolestaroolka LDL. Daraasaddan ayaa shaaca ka qaaday in kordhinta Juxtapid ee daaweynta kale ay hoos u dhigtay heerarka LDL illaa 50%. Heerarka Triglyceride, heerarka "apolipoprotein B", VLDL iyo wadarta guud ee kolestaroolka ayaa sidoo kale hoos u dhacay.
Daraasad kale ayaa baartey waxtarka iyo amniga shakhsiyaadka qaba xaalad caafimaad oo la mid ah Juxtapid oo keliya in ay hoos u dhigto heerarka kolesteroolka. Dhamaadka daraasaddan, qiyaasta 1 mg / kg / maalin, heerarka LDL iyo heerarka apolipoprotein B ayaa sidoo kale hoos u dhacay ilaa 50%.
Inkasta oo natiijooyinkani ay gacan ka geysteen hoos u dhigidda kolestaroolka bukaankan, waxay sidoo kale muujiyeen in Juxtapid uu keeni karo waxyeelo muhiim ah - oo ay ku jiraan saameynta daawooyinka caloosha iyo xanuunka beerka.
Intaa waxaa dheer, maaddaama daraasaddan oo kaliya ay socotay illaa iyo 78 toddobaad, haddana daraasado kale ayaa hadda la qabtaa si loo ogaado ammaanka iyo mudnaanta muddada dheer ee Juxtapid.
Sidee Ayuu U Shaqeeyaa?
Juxtapid wuxuu hoos u dhigaa kolestaroolka LDL isagoo xakameynaya borotiinka lakala bedelo microsomal triglyceride (MTTP), molecule ee jirka oo ka hortagaya VLDL iyo chylomicrons in laga sameeyo beerka.
Sababtoo ah VLDL waxaa loo beddelaa LDL, tani waxay sidoo kale hoos u dhigeysaa heerarka LDL ee dhiigga.
Sidee Ayaan U Qaadi Karaa Daawadan?
Juxtapid waa in la qaataa afka, iyada oo galaas biyo ah, calool madhan. Waxaa la soo jeediyey in daawada la qaato ugu yaraan laba saacadood ka dib cashada. Bixiyahaaga daryeel caafimaad ayaa kaa qaadi doona tijaabooyinka dhiigga - oo ay ku jirto baaritaanka unugyada beerka iyo heerarka kolesteroolka - ka hor inta aadan u qorin Juxtapid.
Waxyeelooyinka Laga Helo
Enzymes beerka oo sareeya iyo isku darka dufanka beerka ayaa si aad ah loola xiriiriyay qaadashada Juxtapid. Sidaa daraadeed, dhakhtarkaagu wuxuu u baahan doonaa inuu qaato tijaabo dhiig ah si loo ogaado heerarka enzymes ee beerka, oo ay ku jiraan alanine aminotransferases, aspartate aminotransferases, iyo fosfatase alkaline, marka lagu daro kormeerida heerarka baruurta. Iyadoo ay sabab u tahay dhibaatooyinka soo socda, Juxtapid wuxuu qabaa "digniin madow" oo loogu talagalay hepatotoxicity, taas oo ah digniin xooggan oo ay soo saartey Maamulka Cuntada iyo Maandooriyaha sababtoo ah xaqiiqda ah in saameyntan ay keentay daraasaddaha baaritaanka ammaanka daroogada. Sababtoo ah saameynta ugu nugul ee Juxtapid waxay leedahay beerka, dhakhtarkaagu wuxuu kuu qori doonaa barnaamijka xaddidan, oo loo yaqaan barnaamijka Juxtapid REMS.
Barnaamijkan oo dhan, dhakhaatiirta iyo farmashiyayaasha oo keliya ee lagu aqoonsaday fahamka daawada iyo khatartooda waxay u qori karaan oo qaybin karaan Juxtapid.
Dhibaatooyinka xasaasiga ah, sida lallabbo, matag, miyir-qabatin, shuban, calool-istaagga iyo xanuunka caloosha, ayaa ah kuwa ugu badan ee lagu soo warramey saamaynta ay dadka ka qaataan Juxtapid. Shakhsiyaadka qaar ayaa sidoo kale soo wariyay miyir beelid, xanuunka feedhaha, iyo daal markaad qaadato daawada.
Yaa qasab ah inaanan qaadan?
Waqtigaan, Juxtapid waxa kaliya oo lagu bartaa dadka lagu sheegay cudurka macaan ee familiga ah ee loo yaqaan 'hypercholesterolemia' sababtoo ah khatarta sare ee cudurrada wadnaha.
Sidaa daraadeed, lama yaqaan haddii Juxtapid uu yahay mid wax ku ool ah shakhsiyaadka qaba xaalado caafimaad oo kale oo keena heerarka sare ee kolestaroolka. Dadka kale ee ay tahay inay la tashadaan dhakhtarkooda kahor intaadan qaadan Juxtapid waxaa ka mid ah:
- Shakhsiyaadka qaba cudurka beerka - Juxtapid waxay sii kordhin kartaa unugyada beerka sida transamasaska iyo kordhinta dufanka beerka.
- Dadka qaba kalyaha - heerarka Juxtapid waxay kor u qaadi karaan dhiigga.
- Dumarka uurka leh - Juxtapid ayaa lagu muujiyey inay waxyeello u tahay ilmaha caloosha ku jira daraasaadka xayawaanka. Haweenka awood u leh inay wax taraan waxay u baahan doonaan inay baaritaan ku sameeyaan uurka kahor inta aysan bilaabin Juxtapid waxayna u baahan doonaan inay isticmaalaan nooc ka mid ah hannaanka xakameynta dhalmada inta ay qaadanayaan daawada.
- Haweenka xannaaneynaya - Juxtapid looma aqoonin si ballaaran. Sababtoo ah suurtagalnimada horumarinta burooyinka ee jiirarka, waxaa lagu talinayaa in kalkaalinta - ama daroogada - waa in la joojiyaa.
Isdhexgalka daroogada
Waxaa jira daawooyin gaar ah oo laga yaabo inay la falgalaan Juxtapid, taas oo keeni karta saameynta saameynta Juxtapid ama daawooyinka kale ee jirka ku jira. Kuwa soo socda waa liis kooban oo daaweyn ah oo la macaamilaya Juxtapid sidaa daraadeed haddii aad qaadato mid ama in ka badan oo ka mid ah daawooyinkan, waa inaad la tashataa takhtarkaaga.
- Fitamiino iyo nafaqeeyayaal, sida Vitamiin A, D, E, iyo K, iyo omega-3 acids , lagama yaabo in loo nuugo sidoo kale marka aad qaadanayso Juxtapid.
- Juxtapid wuxuu kordhin karaa heerarka dhiiga ee dhiig-yare , sida warfarin, dhiigga. Tani waxay kuu keeni kartaa inaad si fudud u dhiigbaxdo ama ujirto.
- Haddii aad qaadatid atorvastatin ama simvastatin, Juxtapid wuxuu kordhin karaa heerarka dhiigga daawooyinkaas. Dhakhtarkaaga ayaa laga yaabaa inuu wax ka beddelo qiyaastaada daawooyinkaan inta aad qaadanayso Juxtapid.
Sababtoo ah habka Juxtapid ee jidhka lagu naqshadeeyo, wuxuu kordhin karaa heerarka dhiigga ee daawooyinka kale ee aad qaadato - sidaas darteed sameynta daawooyinka si aad u xun. Kuwaas waxaa ka mid ah daawooyinka antifungal, daawooyinka antibiyootikada, daawooyinka fayruska, daawooyinka cadaadiska dhiigga, daawooyinka loo isticmaalo daweynta miis-qallooca, iyo alaabta dabiiciga ah (sida dahabka, sheygaarka). Sidaa daraadeed, waa inaad ilaaliso dhamaan bixiyeyaasha xanaanada caafimaadkaaga wixii daawooyin ah ee aad qaadanayso si ay ufilan karaan si ku filan si ay ufilan u yeeshaan isdhexgalka suurtagalka ah ee Juxtapid. Dhakhtarkaaga ayaa laga yaabaa inuu go'aansado inuu beddelo qiyaastaada Juxtapid ama daawooyin kale haddii isdhexgalka la ogaado.
Khadka hoose
Juxtapid waa daawada ugu horeysa ee kolesteroolka oo la ogolaaday in la joojiyo MTTP. Inkastoo daraasaduhu muujiyeen in Juxtapid ay ku kordhinayso awood dheeri ah LDL-hoos udhaca awoodda shakhsiyaadka qaba hoomamirada 'hypercholesterolemia' ee familiga ah, waxaa jira arrimo badan oo nabadgelyo oo la xidhiidha Juxtapid waxaana isticmaalkooda loo xaddidayaa xaaladdan cudur ee gaarka ah sababtoo ah khatarahaas. Dhakhtarkaagu wuxuu qiimeyn doonaa faa'iidooyinka uu qaadanayo Juxtapid, oo ay weheliso halista ah inuu ku dhaco saameynaha daawada. Sababtoo ah saameynta muddada dheer ee qaadashada Juxtapid lama garanayo - oo ay ku jirto awoodda looga hortago cudurada wadnaha - waxaa jira daraasado hadda socda si loo baaro.
Ilaha:
Cuchel M, Meagher EA, Theron HD, et al. Waxtarka iyo nabadgelyada ilmagaleenka borotiinka ee loo yaqaan "microsomal triglyceride" inhibitor ee bukaanada leh familial hypercholesterolemia: oo ah hal-gacmeed, calaamado furan, marxalada 3 daraasadda. Lancet 2013; 381 (9860): 40-6.
Cuchel M, Bloedon LT, Szapary PO, et al. Ka hortagga borotiinka borotiinka ee mikrosomal triglyceride ee foosha 'hypercholesterolemia'. N Eng J Med 2007; 356: 148-156.
Juxtapid ® (lomitapide) Ku rid baakadka. Farmasiyada Aegerion. Maarso 2016.