Dhacdooyinka Daaciga ah ee La Xiriira Maadada ama afka NSAIDs ayaa kaa caawin kara inaad go'aansato
Daawooyinka aan dawooyinka ahayn ee ka hortagga uurka (NSAIDs) ayaa ka mid ah daawooyinka ugu caansan iyo kuwa ugu badan ee daawooyinka loogu talagalay arthritis. NSAIDs waxaa loo qaadan karaa hadal ahaan kiniinnada, kiniiniyada ama dareeraha. NSAIDs ayaa sidoo kale laga heli karaa habka miisaanka, sida kareem, jel ama dareeraha lagu daboolo maqaarka.
Sidee Ayuu NSAID-ku Shaqeyn Karaa?
Maaddooyinka NSAID-yada, sida topical ibuprofen ama Voltaren gel , ayaa lagu dabaqaa maqaarka si ka baxsan xannuun culus.
Waxaa jira faa'iidooyin gaar ah oo la xariira NSAID-yada jirka oo ay ku jiraan:
- daroogada sii kordhaysa ee unugyada ay saameysay
- hoos u dhac ku yimi saameynaha hab-nololeedka ah sida cudurka boogaha peptic iyo dhiig-baxa caloosha
Maaddooyinka NSAID-yada oo si tartiib ah u gala, waxay yareynayaan wareegga wareegga. Marka la barbardhigo afka Afqaanistaan NSAID, codsiga miisaanku wuxuu keenaa nafaqada NSAID-ka ee sarreeya ee maqaarka (lakabka maqaarka ee ka hooseeya epidermis ka kooban unugyo isku xiran). Goobaha lagu gaadho unugyada muruqyada ee ka hooseeya goobta codsiga way kala duwan yihiin, laakiin ugu yaraan waxay u dhigantaa waxa ku guulaystay maamulka afka ee NSAIDs.
Maaddooyinka NSAID-ku waxa ay gaari karaan dheecaanka synovial , laakiin intee dhan iyo habka saxda ah ee aan weli la go'aaminin. Farqiga shaqsiyadeed ee maqaarka ayaa laga yaabaa inay ku xisaabtamaan isbeddellada qaarkood ee lagu arkay nuugista NSAID-yada jirka.
Guud ahaan, way adag tahay in la ogaado in maadada ama afka NSAID ay wanaagsan tahay sababta oo ah waxaa la soo bandhigay in tijaabooyinka kiliinikada ay jirto heer aad u sarreeya.
Dadka waxay soo sheegaan xanuunka xitaa haddii aysan jirin wax firfircoon kiniinka ama kareemka.
Sidee Looga Shaqeyn Karaa NSAID-yada Afka?
Oral NSAIDs waa kaniiniyo, kondhom ama daawooyin dareere ah oo la liqo. Waxay ku maraan nidaamka dheef-shiidka waxayna ku faafaan dhiigga, iyagoo saameynaya jidhka oo dhan. Oral NSAIDs waxay ka shaqeeyaan joojinta cyclooxygenase (COX) , enzim kaas oo kiciya aalado arachidon ah prostaglandins iyo leukotrienes.
Arachidone acid waxaa laga sii daayaa phospholipids xayeysiis ah oo ka jawaab celinaysa kicinta infakshanka. Prostaglandins waxay dejiyaan jawaabta bararka. NSAIDs waxay farageliyaan soo saarida prostaglandins by kicinta cyclooxygenase.
Kala duwanaanshaha Dhacdooyinka Dhibaatooyinka ah ee u dhexeeya NSAID iyo Afka Naaska
NSAID-da mawduucyada ah waxay leeyihiin nuuc ka fiican xagga caafimaadka afka ee NSAIDs. Dhibaatooyinka xun ee ku yimaada isticmaalka NSAID-da ee miisaankeedu wuxuu dhacaa qiyaastii 10 ilaa 15% bukaanada waxaana ugu muhiimsan qashinka (finan iyo cuncun - cuncun - meesha NSAID la mariyo). Dareen-celinta daroogada ee dheef-shiid kiimikaadka ah ayaa dhif ah nuucyada NSAID-yada ah, marka la barbardhigo 15% dhacdooyinka lagu soo warramey afka Afqaanistaan.
Sidee Bukaannada u Xulaan Inta u dhaxeysa NSAID iyo Afka Naaska
Laga soo bilaabo laba warbixinno lagu soo daabacay Jariidadda Caafimaadka ee Britishka (BMJ) , waxaay caddayn in go'aanka lagu soo rogay habka NSAID-ka, afka ama habka loo isticmaalo ay caadi ahaan ku saleysan tahay:
- aragtida bukaanka ee halista saameynta xun
- jiritaanka jirro kale
- heerka xanuunka
- talada la helay
- waxqabadka (qiimaha iyo sahlan isticmaalka)
BMJ , cilmi-baadhayaashu waxay soo gabagabeeyeen in "NSAID-yada jirka oo ah mid habboon oo ammaan ah oo lagu beddeli karo afka NSAID-ka si loogu daaweeyo jilibka osteoarthritis , xitaa haddii saameynta placebo ay sharraxayso badi qiimaha wakiillada maan-dooriyeyaasha ah."
Sida had iyo jeer, kala hadal fursadahaaga dhakhtarkaaga oo wadajir u shaqee si aad u ogaato taas oo ah doorashada ugu fiican ee xaaladdaada iyo xaaladdaada.
> Ilo:
> Afku waa ka soo horjeedaa NSAID-yada daawada ee rheumatic ah: isbarbardhig. Daroogooyinka. 2000 Sep; 60 (3): 555-74. Heyneman CA et al.
> Afka iyo daaweynta NSAID ee loogu talagalay xanuunka OA - sida iyo sababta ay dadku u doortaan daaweynta. December 5, 2007. > UKMiCentral >. NHS.