HIV-iyo kuwa aan HIV-ga la xiriirin ee kor u kaca
Dhacdooyinka kansarka ee dadka la nool HIV ayaa muddo dheer ku jiray welwel iyo diiradda cilmi baaris caafimaad oo sii kordhaya. Inkastoo halista kansarka noocan oo kale ah sida Kaposi sarcoma iyo non-Hodgkin lymphoma (NHL) ay hoos u dhaceen sababtoo ah horumarka daaweynta antiretroviral , dhacdooyinka kansarka kale ayaa kor u kacay.
Kansarradaas aan ku salaysneyn AIDS-ka ayaa maanta loo tixgelinayaa sababta keentay dhimashada dadka qaba cudurka HIV-ga ee caalamka soo kordhay, sida laga soo xigtay cilmibaaris ka soo baxday cilmi baarista Swiss HIV Cohort. Dhibaatooyinka kansarka sida kansarka sanbabada iyo kansarka futada ayaa hadda ka shaqeeya meel kasta oo ka socota sadex ilaa 50 jeer ka weyn kuwa guud.
AIDS-Kansarka Qeexaya
Horraantii 1980-yadii, nooc ka mid ah kansarka maqaarka oo la yiraahdo Kaposi sarcoma (taas oo ilaa intaa ka dib, ugu horreyn ay saameysey ragga waayeelka ah ee Bariga Yurub) ayaa ka mid ahaa koox cudur ah oo lagu arko dadka lagu arkay cudurka HIV. 1981. Wax yar ka dib, lymphoma aan ahayn Hodgkin lymphoma iyo kansarka ilmo-galeenka ilmo-galeenka (ICC) ayaa lagu daray liiska iyada oo kaneecada loo aqoonsaday AIDS-qeexitaan.
Iyada oo la hirgelinayo daaweynta antiretroviral ee isku-dhafan (ART) ee 1996, ayaa muuqaalkii isbedelay. Halkaan waxaa lagu soo rogay daroogo daaweyn ah oo hadda si buuxda u xakameyn karta fayruska iyo dib u soo celinta howlaha difaaca jidhka, dhacdooyinka Kaposi iyo NHL hoos u dhac ku dhowaad 50%, halka ICC ay sii wadi doonto isbadaladan ilaa maanta.
(Sababta tan looma fahmin in kastoo qaarkood ay rumaysan yihiin in qaar ka mid ah noocyada daaweynta papillomavirus (HPV) ee aan la garaneynin ee kansarka ilmo-galeenka - ay ku sii fidi karaan haweenka qaba HIV.)
In kasta oo qaar badan oo ka mid ah horumarintaan, dadka qaba HIV ayaa weli ilaa toddoba jeer u badan inay u soo baxaan ICC, 65 jeer waxay u badan tahay inay hormariyaan NHL, iyo 300 jeer ay u badan tahay inay ka soo kabtaan Kaposi sarcoma marka la barbar dhigo kuwa aan cudurka qabin.
Cudurrada aan-Laheyn ee Kansarka ah
Iyada oo ay si ballaaran u korodhsan tahay rajada nolosha dadka oo ay sabab u tahay ART iyo da'da si tartiib tartiib ah ee HIV-ga, cilmi-baarayaashu waxay bilaabeen inay arkaan noocyo kale oo kansar ah oo u muuqda kuwo si joogto ah u muuqda dadka qaba HIV. Tirada ay kuwaani dhaceen waxay keeneen dad badan oo rumeynaya in ay jirto xiriir ka dhexeeya HIV iyo noocyada kansarka qaarkood.
Qaar ka mid ah kuwan oo kale, sida kansarka futada , xiriirku wuxuu u muuqday mid cad. Marka aan si weyn u muuqan Mareykanka, wax yar ka badan 20,000 xaaladood ayaa laga soo sheegay intii u dhaxaysay 1980-kii iyo 2005-kii, cudurka kansarka maanta waa afaraad ee kansarka ugu badan ee laga helo dadka qaba HIV-ga. Waxaa intaa dheer, rag ama dumar bisexual ah oo HIV qaba ayaa laga yaabaa in ay haystaan 60 jeer fursad weyn oo ay u yeeshaan kansarka futada marka loo eego shakhsiyaadka aan cudurka qabin.
Sidoo kale, cudurka Hodgkin (nooc ka mid ah kansarka dhiigga oo la mid ah kuwa aan ahayn Hodgkin lymphoma) wuxuu u dhexeeyaa shan illaa 10 jeer isdaba-marinta saameynta dadka qaba HIV, halka kansarka madaxa iyo kansarka beerka ay yihiin, siday u kala horreeyaan, sideed iyo sagaal jeer oo ka badan dhacaan.
Dhammaantood waxay u sheegeen kansarka maskaxda, afka, dhuunta, sanbabada, beerka, kelyaha, afka ilmagaleenka, anuska iyo unugyada lymfaha ayaa loo arkaa inay si aan kala sooc lahayn u saameynayaan dadka qaba HIV, iyadoo inta badan lagu ogaado 10-15 sano ka hor kuwa ka mid ah kuwa aan cudurka qabin.
(Dhinaca faleebada, dadka qaba HIV guud ahaan looma arko inay halis kasta oo sare ah u tahay horumarinta kansarrada naasaha, ugxan-yarta, kaadiheysta, prostate, mindhicirka ama malawadka.)
Sababtoo ah Khatarta Kordhinta
Qaar ka mid ah jeermisyada ayaa la muujiyey inay ka qaybqaataan khatarta kordhaysa, sida cagaarshow C iyo kansarka beerka; HPV iyo kansarka afka ilmagaleenka / afka ilmo-galeenka; iyo Epstein Barr virus iyo cudurka Hodgkin.
Dhanka kale, arrimaha dhaqameed ee hab nololeedka, sida sigaarka iyo khamriga, waxay sii adkeyn karaan halista, gaar ahaan kansarka sanbabada ama kansarka.
Muhiimad ahaan, laga yaabee, waa doorka HIV ee laftiisa. Inkastoo aan ognahay in HIV uusan gaar u ahayn kansarka, infakshanka joogtada ah ee infekshanka leh ayaa u muuqda in uu si xooggan loola xiriirinayo heerarka sare ee cudurka.
Tani waxay u muuqataa mid run ah xitaa marka bukaanadu ay ku jiraan ART iyada oo si buuxda loo arki karo culeyska fayraska .
Cilmi-baarista maanta waxay si xoog leh u soo jeedinaysaa in caabuqyada joogtada ah, xitaa heerka hooseeya, ay uuraysan karaan nidaamka difaaca jirka. Tani waxay sii xumaatay (oo loo yaqaan 'senescence premes') waxaa loo arkaa mid dabiici ah dadka waayeelka ah. Si kastaba ha noqotee, bararka HIV-ga la xidhiidha, gabow gabaygan oo keliya ayaa sii kordhay oo keliya waqtiga qaadista kansarka, sidaas awgeedna xaalado badan oo kale oo la xidhiidha da'da, oo ka yimaada nuuro la'aanta xagga lafaha oo ka sii daraya cudurrada wadnaha .
Sidee loo yareeyaa Halista Kansarkaaga
Furaha yareynta khatarta kansarka waa ogaanshaha hore iyo daaweynta infekshanka HIV. Bilowga ART ah xilliga baaritaanka waxay ku celin karaan ama dib u soo celin karaan fayoobka difaaca caafimaad iyagoo yareynaya khatarta kansarrada qaarkood ilaa 50 boqolkiiba.
Talooyinka kale ee dadka qaba HIV-ga waxaa ka mid ah:
- Baaritaanka sanbabada ee Pap smear oo loogu talagalay kansarka ilma-mareenka
- Cagaarshowga B iyo baaritaanka hepatitis C
- Baadhitaannada Pap smears oo ku saabsan ragga iyo dumarka ama qof kasta oo leh finan yaryar
- Tallaalka HPV ee haweenka da'doodu udhaxayso 11 ilaa 26 jir, ragga da'doodu u dhaxayso 11 ilaa 21, raga galmada firfircoon ee raggu u galmoodaan (MSM) da'da 22 ilaa 26, ama ragga da'doodu u dhaxayso 22 ilaa 26
- Joojinta sigaarka
- Yareynta isticmaalka aalkolo, gaar ahaan dadka qaba cagaarshow B ama C
- Hawlaha galmada ee badbaadada si looga hortago cagaarshow C iyo HPV
- Tijaabooyinka kale ee baarista kansarka oo gaar ah sida uu takhtarku ku faray
Ilaha:
Hleyhel, M .; Belot, A .; Bouvier, A., et al. "Halista cudurka kansarka AIDS-ka ee cudurka HIV-1 (1992-2009): natiijooyinka ka soo baxa FHDH-ANRS CO4." Wargeyska Ururka Caalamiga ah ee AIDS. Nofeembar 11, 2012; 15 (4)
Crum-Cianflone, N., MD; Huppler Hullsiek, K., PhD; Vincent Marconi, Vm MD, et al. "Isbedelka ku dhaca dhacdooyinka kansarka ee dadka qaba cudurka HIV iyo saameynta daaweynta antiretroviral: Daraasad 20-sano ah oo loo yaqaan 'Cohort Study." AIDS , 2009; 23 (1): 41-50.
Shiels, M .; Pfeiffer, R .; Gail, M., et al. "Cancer Burden ee dadka qaba cudurka HIV-ga Maraykanka." XVIII Shirkii Caalamiga ahaa ee AIDS-ka, Vienna. Abstract WEAB0101, 2010.
Nguyen, M .; Farrell, K .; iyo Gunthel C. "Maqnaanshaha AIDS-ka ee Qeexidda Xanuunada ee bukaan-jiifka qaba HIV ee HAART Era: Warbixinta Cudurrada Cudurka Xaadirka ah." Warbixinta Cudurrada faafa ee hadda. Janaayo 2010; 12 (1): 46-55.
Chao, C .; Leyden, W .; Xu, L., et al. "Ku soo noqoshada daaweynta antiretroviral iyo khatarta kansarka ee dadka qaba cudurka HIV." AIDS. Nofeembar 13, 2012; 26 (17): 2223-31.