Bartilmaameedka Myelin-Producing Noocyo Waa Tallaabadda Xiga ee MS Therapy
Daawooyinka hadda jira ee sclerosis badan ayaa diirada saaraya nidaamka difaaca jirka. Inkastoo ay heleen in la yareeyo lambarka iyo darnaanta cudurrada MS, weli wali ma jirto daawo MS, si dadku u sii wadaan inay noqdaan kuwo naafo ah markii cudurku uu sii socdo.
Hase yeeshee, khubarada ayaa baadhaya daaweynaha oo bartilmaameed u ah myelin - xakamaynta dareeraha ku xeeran ee ku xeeran MS.
Aan fiirino aragti ah maareynta maskaxda ee sclerosis, iyo sida dayactirka loo soo celin karo hawlaha neerfaha iyo hoos u dhigo ama xitaa joojiso MS ee jidadkeeda.
Nooca Myelin ee Isku-dhafan ee Sclerosis
Qofka caafimaadka qaba, unugyada dareemayaasha waxay u diraan dareenka isdhaafka fibbane khafiif ah oo ku xiran jirka jirka unugyada. Saadaashadaan khafiifka ah waxaa lagu magacaabaa axons waana ku hareereysan dufsi, cadaan cad oo loo yaqaan 'myelin'. Iyada oo loo adeegsanayo daboolka difaaca ama daboolista, myelin waxay u oggolaaneysaa dareen-celinta dareenka si degdeg ah oo wax ku ool ah.
Meelaha sclerosis , maskaxda unugyada difaaca ee qofku (iyo ugu dambeyntii xitaa xitaa xitaa) maskaxda iyo / ama xudunta lafdhabarta. Weerarrada soo noqnoqda ee ku dhaca maareynimada ayaa ugu dambeyntii horseedaya nabaro. Marka maskaxdu ay jabiso, dareen-celinta dareenka si habboon looma gudbin karo-iyaguna si tartiib ah ugama socdaan ama ma ahan. Ugu dambeyntiina, faaruqintu waxay u jahawareeraan (waxay luminayaan awooddooda inay shaqeeyaan) sababtoo ah luminta maskaxda daba dheeraatay, taasoo keenta dhimashada unugyada dhimirka.
Iyadoo ku xiran halka ay ku jirto habka maskaxda dhexe ee la yiraahdo myelin waa la weeraray, calaamadaha sida waxyeellada dareenka, dhibaatooyinka aragga, xuubka, iyo dhibaatooyinka kaadiheysta waxay bilaabaan inay muujiyaan. Tani waa sababta calaamadaha MS ay si aad ah u kala duwan yihiin qof qof kale, maaddaama meesha ay ka socdaan weerarrada myelin ay ku kala duwan yihiin habka dhexe ee neerfayaasha.
Marka lagu daro xarumaha isbeddelka ee habka difaaca jirka ee weerarka maskaxda iyo xangulaha, wakhtiga weerarradan waa mid aan la saadaalin karin-inkastoo, khubarada ayaa tilmaamaya kiciyaasha waxyeellada leh sida walaaca ama xilliga dhalmada kadib.
Dayactiridda Myelin: Talaabada xigta ee MS Therapy
Iyadoo cudurada isbedelaya ee daaweynta MS ay diiradda saaraan sidii looga hortagi lahaa nidaamka difaaca jirka ee weerarka myelin, hadda cilmi-baarayaashu waxay eegayaan sida ay myelin ugu kabi karto markii uu waxyeelo ka soo gaaray habka difaaca jirka. Rajada ayaa ah in haddii miisaanku dayactirayo, shaqsiyaadka neerfaha qofka ayaa la soo celin karaa, iyo MS-da ayaa joojin karta inay sii xumaato (ama ugu yaraan hoos u dhigto).
Warka wanaagsani waa in daraasadaha qaarkood ay horey u muujiyeen in ilaalinta iyo dib u soo celinta maareynta meheradaha ku wareegsan xaaraannadu ay kordhin karaan badbaadada unugyada unugyada. Maadaama macaamilka naafanimada qaba ee MS uu ku xiran yahay heerka dhimashada unugyada, iyadoo la dayactirayo unugyada myelin iyo ilaalinta unugyada dareemayaasha, khubarada ayaa rajeynaya inaan joojin karno horumarka naafada ee dadka qaba MS.
Horumarinta MS Research ee Myelin Repair
Cilmi-baarista dib u soo celinta shaqada iyo dayactirka maareynta maskaxda ee multiple sclerosis weli waa mid goor hore. Si kastaba ha ahaatee, waa mid xiiso leh oo suurogal u ah talaabo u dhow in la soo afjaro MS mar iyo dhammaanba.
Mid yar, daraasaddan II ee Jaamacadda California San Francisco ayaa lagu soo bandhigay kulliyadda Agaasinka Aqoonyahanka ee sanadlaha ah. Daraasaddan, daawada xasaasiyadda 'alert' ee loo yaqaan 'clemastine' ayaa la baaray si loo ogaado haddii ay kor u qaadi karto dayactirka myelin ee maskaxda ee dadka qaba MS.
Daraasaddan, 50 qof oo qaba dhaawacyada mindhicirka ee MS iyo optic ayaa la siiyay clamastine afkiisa laba jeer maalintii ama kaniinada placebo 150 maalmood. Kadib 90 ka mid ah 150-kii maalmoodba, ka qaybqaatayaashu waxay bedeleen daaweyn, taas oo macnaheedu yahay kuwa heley clemastine waxay markii hore heleen placebo iyo sida kale.
Ka qaybgalayaashu waxay ku dhaceen waxyaabo muuqda oo muuqda, kuwaas oo cabbira isbeddelka isdaba-marinta ee indhaha indhaha iyada oo loo marayo dareemaha indhaha si ay u noqoto kortex-muuqaal-gobolka maskaxda ee hirgeliya sawirada, ama si kale loo dhigo, waxa uu u beddelaa waxaad aragtay sawir dhab ah.
Natiijooyinka ayaa muujiyay in dib u dhaca ku yimid muuqaalka suuragalka ah ee la ogaaday in la yareeyay 1.9 milisanimoon halkii isha loogu talagalay waqtiga dadka lagu daaweeyay clemastine. Hoos-u-dhackan dib-u-dhac ku yimaada ilayska ayaa muujinaya in dayactirka maskaxdu uu ku dhacayo marinka indhaha ee dareemayaasha.
Mid ka mid ah wargeyska daraasaddan ayaa ah in qiyaasta clemastine ay ka sarreeyeen qiyaasta ugu badan ee lagu taliyo, sidaasi daraadeed ma ahan wax la yaab leh, waxay keentay daal aad u yar ka qaybgalayaasha.
Daawooyinka Myelin-Daawaynta ee Hawlgalladii hore
Daraasadaha kale ee hore waxay qorayaan bukaanka ama hadda socda oo ku saabsan daawooyinka laga yaabo inay gacan ka geystaan kor u qaadista tamarta iyo ilaalinta unugyada dareemayaasha ee habka dhexe ee dareenka.
Tusaale ahaan, marxaladaha wajiga 1aad (horeyba) way socotaa labada Olesoxime iyo Guananbenz labadaba.
Guanabenz (dawo hore u ansixisay FDA oo lagu daaweynayo cadaadis dhiig oo sarreeya) ayaa laga helay daraasaadka xayawaanka si loo kordhiyo noolaanshaha unugyada soo saaro myelin (loo yaqaan oligodendrocytes). Waxa kale oo la helay in la yareeyo tirada unugyada difaaca jirka ee soo ururiya maskaxda iyo xangulada laf-dhabarta.
Daawo kale oo loo yaqaan Olesoxime , oo asal ahaan loo soo saaray si loogu daaweeyo daawada amyotrophic lateral sclerosis , ayaa lagu ogaadey in ay labadaba dardar geliyaan unugyada unugyada maskaxda ee maskaxda iyo xangulaha lana hormariyo maskaxda.
Quetiapine waa neef- wareer aan caadi ahayn oo lagu ogaadey in uu leeyahay qaabab dib u habeyn lagu sameeyo xayawaanka xoolaha ee MS. Waxaa la rumeysan yahay in la ilaaliyo oo kiciyo koritaanka unugyada dareemayaasha ee sameeya maareynta maskaxda (oligodendrocytes) iyo in la joojiyo unugyada difaaca jirka ee ku lug leh weerarka miinada ee MS.
Marka laga soo tago in ay suurta gal tahay in la dayactiro maskax ahaan dadka qaba MS, oo ah daaweyn cillad maskaxeed, waxaa kale oo laga yaabaa in ay leedahay faa'iido dheeraad ah oo lagu daaweynayo dhibaatooyinka niyadda iyo cabudhinta MS. Daraasad dose-helid ah oo labadaba dib-u-soo-ceshadaynta MS-ga iyo horumarinta MS ayaa sii socota.
Ereyga
Fikradda ah in daroogadu awood u leedahay inay kor u qaaddo dayactirka myelin ee habka dhexe ee neerfaha waa mid xiiso leh. Waxay soo jeedinaysaa in maskaxdu ay is-hagaajin karto, dib u soo celinta hawlaha neerfaha ee mar horeba lumay ama lumay.
Taas oo la yiraahdo, tani waa wax waliba oo cusub oo aad u horeeya. Markaa xiiso u leh kuwa naga mid ah ee leh MS, iskuday in aad bukaanka sii wadato sida cilmi-baaristu u socoto.
> Ilo:
> Harlow DE, Honce JM, Miravalle AA. Daaweynta sifeeynta ee ku taala sclerosis multiple. Neurol hor. 2015; 6: 257.
> Nave KA. Maqalka iyo taageerada koobabka ee axsaabta dheer. Nar Rev Neurosci. 2010 April; 11 (4): 275-83.
> Ururka Shaqaalaha Qaran ee MS. (Abriil 2016). Antihistamine waxay muujinaysaa caddaynta dhiirigelinta dayactirka Myelin ee Wareega II ee MS.
> Zhornitsky S et al. Quetiapine fumarate oo loogu talagalay daaweynta cudurka sclerosis ee badan: xoogga saari maareynta maskaxda. CNS Neurosci Ther . 2013 Oct; 19 (10): 737-44.