Daraasad cilmi-baaris ah ayaa lagu ogaaday halis, laakiin tirakoobka dhabta ah ee dhabta ah ee dhabta ah ee halista lymphoma iyo labo kansar oo kale ee bukaanka qaba cudurka psoriasis. Laakiin, waxaa jiri kara sheeko intaa ka badan marka la eego isha.
Psoriasis
Cudurka psoriasis waa mid ka mid ah cudurrada maqaarka ee ugu caamsan, oo la xiriira calaamadaha sida cuncunka, xanuunka, ama dhiigbaxa. Meelaha ku lugta leh maqaarku waxay u egyihiin meelo guduudan, oo kor loo qaaday oo loo yaqaan platelets, kuwaas oo lagu dabooli karo qulqulka qalajinta.
Noocyada kala duwan ee cudurka psoriasis waxay yeelan karaan muuqaalo kala duwan iyo siyaabo kala duwan ee maqaarka ku lug leh.
Cudurka psoriasis waxaa loo tixgeliyaa xaalad barar ah , kaas oo laga yaabo in uu saameyn ku yeesho-iyo isirada la wadaago cudurrada kale, oo ay ka mid yihiin kansarka qaarkood. Dadka qaba cudurka psoriasis waxay u muuqdaan inay qandaraasyo kale, cudurrada suurtagalka ah ee la xidhiidha ay ka badan yihiin inta la filayo in lagu saleeyo tirooyinka guud ee dadweynaha, oo ay ku jiraan:
- Cudurka jahwareerka (Psoriatic arthritis)
- Cudurka jirrada ee Crohn
- Qaar ka mid ah malignancies
- Murugo
- Cudurka beerka dufanka aan lahayn
- Cudurka Metabolic iyo xanuunka wadnaha
Lymphoma
Lymphoma waa kansar saameynaya lymphocytes, nooc ka mid ah unugyada dhiigga cad oo laga helo dhiigga iyo sidoo kale ku yaalla dhuuxa lafta iyo limfa noodeska . Hodgkin's lymphoma, ama HL, iyo non-Hodgkin's lymphoma , ama NHL, waa labada qaybood ee ugu muhiimsan ee lymphoma.
Sababtoo ah lymphocytes waa qayb ka mid ah nidaamka difaaca, cilmi-baarayaashu waxay la yaabeen xiriirka ka dhaxeeya cudurrada difaaca iyo lymphoma.
Ilaa hadda, waxay sii wadaan inay isku dayaan inay fahmaan xiriirka ka dhexeeya labadaba.
Psoriasis & Lymphoma: Isku-xirka
Ururka Cancer Society (ACS) hadda ma qoro cudurka psoriasis gaar ahaan qatarta halista ah ee lymfoma. Waxay sameeyaan, si kastaba ha ahaatee, waxaa ka mid ah cudurrada korontada ku shaqeeya ee liiska halista asaasiga ah ee NHL, oo ka hadlaya rheumatoid arthritis iyo lupus erythematosus tusaale ahaan.
Rheumatoid arthritis, psoriasis, iyo cudurada wadnaha bararka (IBD) ayaa dhamaantood lagu muujiyay inay la xiriiraan halista sii kordheysa ee lymphoma ee qaar ka mid ah, laakiin maahan dhammaan daraasadaha.
Nidaamka difaaca jirka ee ka-hortagga cudurrada bimuq-mareenka ayaa laga yaabaa inay kobcaan lymphocytes oo ay u kala qaybiyaan inta badan sida caadiga ah, oo ay dhici karto inay sii kordhayso qatarta lenfoma. Maadaama ay ACS tilmaameyso, si kastaba ha noqotee, dadka qaata NHL waxaa laga yaabaa in ay yahiin waxyaabo halis ah oo aan la garanayn; iyo xitaa haddii qof qaba NHL uu leeyahay hal ama dhowr waxyaalood oo halis ah, badanaa waa mid aad u adag in la ogaado inta ay le'egtahay waxyaabahani waxay ku biiri karaan lymphoma.
Heerarka qiyaasta ee lymphoma ayaa lagu soo warbixiyay tiro daraasado ah oo bukaanno qaba cudurka psoriasis. Khatarta lenfomoolka leh walxaha noolaha, guud ahaan, waxay mawduuc ka ahayd dood badan. Wakiilada bayoolojiga ayaa kaalin ku leh daaweynta cudurada sida rheumatoid arthritis iyo psoriasis. Inkastoo ay muujiyeen inay yihiin kuwo amaan ah, waxay ka shaqeeyaan nidaaminta difaaca jirka-sidaas darteed waxaa jira walaac ah in tani ay kor u qaadi karto khatarta kansarka qaarkood.
Waxaa laga yaabaa in ay kordhaan khatarta kansarrada sida lymphoma ee dadka qaba cudurka psoriasis, laakiin waxaa jira dhowr caqabado ah oo ku saabsan barashada noocgan oo kale:
- In kasta oo lymphoma uu yahay mid muhiim u ah caafimaadka dadwaynaha, tirakoobkani waa mid aad u yar marka loo eego cudurka psoriasis, taas oo adkaysay in la helo tiro fara badan oo lagu falanqeeyo.
- Haysashada cudurka psoriasis waa mid ku xiran dhowr arrimood, sida sigaar-cabista, cayilka, iyo daaweynta ultraviolet iyo daawooyinka xakameynaya nidaamka difaaca. Waxyaabahani waxay kordhin karaan halista lymfoma iyo kansarrada kale, oo ka madaxbannaan cudurka psoriasis laftiisa.
Dhawaan, cilmi-baarayaashu waxay falanqeeyay diiwaanka laga helay 198.366 bukaanno qaba cudurka psoriasis iyo 937,716 iyada oo aan lahayn cudurka psoriasis iyada oo la adeegsanayo xogta gudaha Boqortooyada Ingiriiska. Natiijooyinka waxay muujiyeen in ay jirtey yar yar laakiin "halis ahaan" dhab ahaantii "khatarta korodhka ee khatarta kansarka maqaarka, lymphoma, iyo kansarka sanbabada dadka qaba cudurka psoriasis.
Cilmi-baadhayaashani waxay ogaadeen in halista kansarku wax yar ka sarayso bukaanada loo aqoonsaday inay qabaan cudurka psoriasis ee dhexdhexaad ah sida kuwa ka soo horjeeda jirro sahlan. Si kastaba ha noqotee, ma jiro xiriir weyn oo u dhexeeya cudurka psoriasis iyo kansarka naaska, kolon, prostate, ama leukemia, si kastaba ha ahaatee.
Xitaa dhawaanahan, dhakhaatiirta Xarunta Cilmi-baarista Cilmi-baarista ee Wake Forest School of Medicine ee Winston-Salem, North Carolina ayaa sameeyay daraasad la xidhiidha. Waxay xuseen in cudurka psoriasis uu la xiriiro xaalado caafimaad oo badan oo kala duwan ama cuduro kale.
Waxay sidoo kale dareensan yihiin in qiyaasta qatarta ka iman karta cudurka psoriasis-badanaa loo soo sheego dhakhaatiirta iyo bukaanada sida halista uurka-laga yaabo inaanay noqon cabbirka ugu fiican. Inkasta oo khatarta qaangaarka ahi ay faa'iido u yeelan karto, qorayaashu waxay dareemeen in ay ka fekerayaan halista ku jirta shuruudaha khuseysa, halkii ay ka tarjumi lahaayeen shuruudaha, waxay u muuqdaan inay dadka ku hogaamiyaan inay saadaaliyaan saameynta cudurka psoriasis.
Sidaa daraadeed, kooxda cilmi-baarista waxay ku qeexday inay xisaabinayso khatarta ugu weyn ee cudurka psoriasis ee cudurada kala duwan. Xaaladaha la xariira cudurka psoriasis ee ugu xooggan (oo leh khatarta ugu sarreysa) waxay ahaayeen kuwo aan aheyn kansarka maqaarka, melanoma, iyo lymphoma sida halkan ku aragtay:
Cudurka Risqiga Riskaha Jirro-Dhibaato Jirro ah
Kansarka maqaarka 7.5 0.64 1,551
Melanoma 6.12 0.05 29,135
Lymphoma 3.61 0.17 5,823
* Si loo xakameeyo hal kondhomood oo ku dhaca cudurka psoriasis, dhakhtarku waa inuu arko 5,823 bukaan qaba cudurka psoriasis.
Ilaha:
Saleem M, Kness C, Feldman S. Kala duwanaanshaha khatarta ah ee khatarta cudurada keena ee bukaanka qaba cudurka psoriasis. J Am Acad Dermatol . 2016 Dec 13 pii: S0190-9622.
Fuxench ZC, Shin DB, Beatty AO, Gelfand JM. Khatarta kansarka ee bukaanka qaba cudurka psoriasis: daraasad dadweyne ku salaysan oo ku taal Shabakada Hagaajinta Caafimaadka [oo la daabacay internetka kahor daabacaadda Diisembar 16, 2015]. JAMA Oncol.
Boehncke WH, Boehncke S. Ka badan maqaarka-qoto dheer: cabbirka badan ee cudurka psoriatic. Swiss Med Wkly. 2014; 144: w13968.