Ma lahaan karaa heerarka sare ee kolestaroolka oo kordhin kara khatarta istaroogga?
Sida arrimahan kale, sida cadaadiska dhiigga oo sarreeya, kolestaroolka sare wuxuu sidoo kale kordhin karaa khatarta istaroogga.
Kolestaroolku waa walax waxtar leh oo ka qaybqaaya kaydinta kaydka, oo loo yaqaano calaamadaha, gudaha xididdada dhiigga. Lakabyada waxay ku ururi karaan halbowlayaasha wadnaha, kaas oo keena oksijiinka wadnaha, iyo halbowleyaasha carotid, oo keena oksijiinka maskaxda.
Marka la raaco cadaadiska dhiigga sareeya , sonkorowga , sigaar-cabista, iyo cayilka, heerarka sare ee kolestaroolka ayaa si fiican loo aasaasay iyada oo ah arrin halis u ah cudurrada wadnaha wadnaha iyo ragga labadaba. Sida arrimahan oo kale, kolestaroolku sidoo kale wuxuu walwal u yahay istaroog .
Sida wadnaha wadnaha uu dhici karo marka mid ka mid ah xididdada halbowlayaasha ah ay noqoto mid cidhiidhi ah oo xannibay, istaroog ama "maskaxda maskaxda", waxay ka dhalan kartaa xannibaadda halbowlaha keena oksijiinka maskaxda. Si kastaba ha ahaatee, horaantii cilmi-baarista ee degaankan waxay soo saartay go'aano isku dhafan oo ku saabsan kaalinta kolestaroolka istaroogga.
Ragga iyo Xanuunka Qaaxada
Xidhiidhka u dhexeeya kolestaroolka iyo istaroogga waa mid aad u adag sababta oo ah xidhiidhkooda wuxuu ku kala duwan yahay nooca istaroogga iyo nooca kolestaroolka.
Waxaa jira laba nooc oo madax-dhiigfuran ah. Nooca ugu badan ee istaroogga, stroke madax -dhiigfuranka , waxaa sababa qufaca dhiigga. Calaamadaha khatarta ah ee kudhaca walxaha is-galka, oo ay ku jiraan kolestaroolka sare, waxay la mid yihiin cilladaha wadnaha ee wadnaha.
Nooca kale ee weyn ee istaroogga, stroke hemorrhagic , waxaa sababa dillaaca xididdada dhiigga, kaasoo maskaxda ku jiran. Si kastaba ha noqotee, noocyadan istaroogga, kolestaroolka sarreysa ayaa dhab ahaantii u muuqda inuu yareeyo khatarta istaroogga. Istaraatijiyada is-goysyada, dhinaca kale, heerarka kolesteroolka ee sareeya waa halis ah - ma aha kan ugu weyn, laga yaabee, laakiin dhab ahaantii waa halis.
Dhibaatooyin kale oo muhiim ah: Dhammaan dhammaan kolestaroolku waa isku mid. Noocyada kala duwan ee kolesteroolku waxay yeelan karaan saameyn aad u kala duwan oo ah jirka. LDL waa "kolestarool xun" marka la eego awooddeeda waxyeellada wadnaha iyo maskaxda oo ah mid muhiim u ah horumarinta lakabyada wadnaha. Heerarka LDL ee kolestaroolka ka weyn 130 milligaraamkiiba miniliterka (mg / dL) waxay ku xiran tahay khatarta sii kordheysa ee istaroogga istaroogga.
HDL , dhinaca kale, waa "kolestarool wanaagsan". Heerka HDL ee ka weyn 35 mg / dL waxay ka hortagaan isutemic kucunka iyagoo gacan ka geysanaya inay galiyaan LDL beerka iyo ka soo baxa dhiigga iyo iyadoo gacan ka geysaneysa xasilinta dabaqooyinka jira. Heerarka sare ee HDL ayaa sii wadi doona in lagu daro ilaalin, iyada oo faa'iidooyinka ugu weyn ay bixisay heerka HDL ee ka sarreeya 60 mg / dL. Dhinaca kale, heerarka HDL ee ka hooseeya 35 mg / dL waxay ku daraan halista kudhacista.
Kaalinta Daawooyinka Daaweynta Dhiig-Jirka
Daawooyinka loo isticmaalo in lagu yareeyo heerarka kolestaroolka - gaar ahaan, daroogada loo yaqaan 'statins' - ayaa lagu muujiyay inay hoos u dhigto khatarta istaroogga waxayna hoos u dhigi kartaa darnaanta istaroogga, haddii mid dhaco. Iyada oo la yareeyo heerarka LDL, statins iyo daroogada kale ee daroogada hoos loo dhigo waxay ka caawisaa ka hortagga dhirta iyo, marka loo eego, istaroogga iyo wadne xanuunka.
Xaqiiqdii, statins ayaa sidoo kale lagu muujiyay inay hoos u dhigto khatarta istaroogga ee bukaanka qaba heerarka caadiga ah ee kolestaroolka.
Statins sidoo kale waxay ka caawisaa dejinta hanti lacageed ee hadda jira. Statins waxay kaa caawineysaa inay sameeyaan duufaan yaryar iyo xajiin badan, iyaga oo ka dhigaya kuwo u adkeysanaya dillaac. Marka lakabyo dillaac ah, qaybo ka mid ah huurada ayaa jaban oo waxaa lagu qaadaa dhiigga, halkaasoo laga yaabo in ay ku hoydaan halbowlayaasha keena oksijiinka maskaxda. Intaa waxa dheer, huurada dillaacsan waxay kicin kartaa dhiigga xinjirta, taas oo sii kordhinaysa khatarta dhiigga ee xiran. Hase yeeshee, Statins, waxay yareyneysaa bararista waxayna caawisaa ka hortagga xinjirrada inay sameeyaan.
Daraasado cilmi baaris oo ballaadhan ayaa isku xiray xiriiro cad oo u dhexeeya isticmaalka duruufaha iyo hoos u dhaca khatarta istaroogga. Mid ka mid ah falanqaynta maadada (daraasad lagu hubinayo natiijooyinka daraasado kale) ayaa lagu ogaaday in isticmaalka Statin uu yaraynayo khatarta istaroogga 21 boqolkiiba iyo in 10% hoos udhaca heerarka LDL ay keentay hoos u dhac 15.6 boqolkiiba khatarta istaroogga.
Cilmi-baadhisyo gaar ah ayaa muujiyay natiijooyin aad u dhib badan. Daraasado dhowr ah ayaa la ogaaday in inkastoo statins ay bixiso dhimis guud ee halista madax-dhiigfuranka, faa'iidada ugu weyn ayaa laga arki karaa kuwa aan horay u qabin istaroog hore. Inkasta oo ay jiraan waxyaabo faa'iido u keenaya kuwa horay ugu dhacay hal daroogo ama yar-yar-yar, saameyntu way daciif tahay.
Daawooyinka kale ee daroogada ee hoos u dhacaya ma aysan ku haboonayn diiwaanka statins. Si kastaba ha noqotee, daraasado yar yar ayaa muujiyey saameynaha is ilaalinta, gaar ahaan iyada oo gacan ka geysaneysa kor u qaadidda heerka kolestaroolka HDL. Mid ka mid ah daraasadda Lopid (gemfibrozil), tusaale ahaan, waxay muujisay isticmaalka Lopid khatarta istaroogga hoos u dhigtay 31 boqolkiiba - iyadoo faa'iidooyinka ugu badan ee lagu arko bukaannada leh heerarka hoose ee HDL.
Tilmaamaha Hantidhowrka ee Yareynta Khatarta Istaroogga
Tilmaamaha hadda jira waxay dejiyaan yoolal la mid ah kuwa "cholesterol" oo lagu yareeyo khatarta istaroogga iyo khatarta cudurka wadnaha wadnaha. Xeerarkan guud ahaan waxay kugula talinayaan dadka aan lahayn cudur wadnaha oo aan sigaarka cabbin oo aan laheyn cudurada kale ee wadnaha khatarta ah (sida sonkorowga, cadaadiska dhiigga oo sareeya, cayilka, taariikhda qoyskooda wadnaha) waa inay ilaaliyaan wadarta guud ee kolestaroolka ka yar 240 mg / dL, oo LDL ka hooseeya 160 mg / dL iyo HDL ka sarreeya 40 mg / dL.
Si kastaba ha noqotee, dadka qaba cudurrada wadnaha iyo xididada ayaa lagula talinayaa inay ujeedadoodu tahay in heerarka xitaa kolesteroolka si ka wanaagsan looga ilaaliyo cudurka wadnaha iyo istaroogga. Shakhsiyaadkaasi waa inay ilaaliyaan wadarta guud ee kolestaroolka ka hooseeya 200 mg / dL, LDL ka hooseeya 100 mg / dL, iyo HDL ka sarreeya 60 mg / dL.
> Ilo:
> Navi BB, Segal AZ. "Doorka kolesteroolka iyo xayawaanka ee istaroogga." Curron Cancun Rep. 2009 Jan: 11 (1): 4-11.
> Tanaka T, Okamura T > .. > "Dhiigxinjirowga dhiigga iyo khatarta istaroogga ee daraasaadka beesha ama daraasaadka shaqada: dib u eegista daraasadaha Japan ee 20-kii sano ee la soo dhaafay." Keio J Med. 2012; 61 (3): 79-88.
> 2013 ACC / AHA Tilmaamaha ku saabsan Daaweynta Dhiigxinjirowga Dhiigga si loo yareeyo Khatarta Wadnaha Cudurka Wadnaha ee Atherosclerotic ee Dadka waaweyn. Wareegid. 2014; 129: S1-S45 Loo daabacay bogga intarneedka kahor November 12, 2013, doi: 10.1161 / 01.cir.0000437738.63853.7a