Saameynta hidaha iyo dhacdooyinka dhaliilaha ayaa loo maleynayaa in ay keenaan noocyo kala duwan oo arthritis ah. Tusaale ahaan, cilmi baarayaashu waxay go'aamiyeen in boqolkiiba 40 dadka qaba cudurka psoriasis ama cudurka psoriasis ee arthritis ay leeyihiin taariikh qoys oo ka mid ah cudurada ku lug leh qaraabada koowaad. Daraasaadka qoysku waxay muujiyeen in cudurka psoriatic arthritis-ka uu 55 jeer ka badan yahay inuu ku dhaco qaraabada koowaad ee dadka qaba cudurkan marka la barbardhigo kantaroolka aan la xidhiidhin.
Daraasooyinka hidde-qabta, ereyga oo dhammaystirani wuxuu loola jeedaa heerka isku midka ah ee laba-lammaan ee ku saabsan joogitaanka ama maqnaanshaha cudur ama sifo. Heerka isu-galka ee cudurka psoriasis ee arthritis-ka (boqolkiiba 30) aad ayuu uga sareeyaa cudurka psoriasis (boqolkiiba 7). Daraasaadka labadaba ee cudurka psoriasis ayaa muujiyey in ay aad u sarreeyeen oo isku mid ah oo isku mid ah oo labadiinaba la mid ah mataanaha mataanaha ah.
Aqoonsiga gen ee la xidhiidha caqabadaha jirro gaar ah ma aha hawl yar. Waxay ku lug yeelan kartaa:
- Daraasadaha qaraarka ee qoysaska: Raadinta isku dhafashada cudurada qoysaska.
- Falanqaynta kalagoynta: Go'aaminta in hiddaha waaweyni uu ku xiran yahay qaybinta qaab dabiici ah oo khaas ah (ie, dabeecadda la arki karo).
- Falanqaynta isku xirka: Aqoonsiga isdhexgalka ee u dhexeeya gen oo ku saleysan goobtooda koromosoom.
- Falanqaynta Ururka: Xaqiijinta xidhiidhada xogta, kiiskan, raadinta gen genle ama gobolada genome ee wax ku biiriya cudur khaas ah.
- Daraasado ficil ah oo lagu garto jinsiga: Barashada kala duwanaanta dabiiciga ah ama khalkhalka tijaabada ah ee saameynaya hiddo-wadaha, koromosoomyada, iyo waxyaabo kale oo badan.
Maqnaanshaha iyo wareerka? Waa, sida uu noqon karo magacaabista . Laakiin, aynu eegno waxa laga helay.
HLA (Human Leukocyte Antigen)
Helitaanka MHC (isku dhafka weyn ee isku-dhafka ah) ee koromosom 6 wuxuu ahaa mid muhiim u ah barashada waxyaabaha astaamaha hidda ee cudurka psoriasis ee arthritis.
Waxyaabo badan oo hidde ah ayaa la ogaaday. Waxaa jira urur xiriir la leh oo u dhexeeya HLA (human leukocyte antigen) ee MHC loo aqoonsado HLA-C, gaar ahaan HLA-Cw6, iyo u nugulida cudurka psoriasis. Ururka HLA-Cw6 wuxuu wax yar ka yaryahay cudurka psoriasis ee arthritis, halkaasoo HLA-B27 uu aad u xoog badan yahay (gaar ahaan dadka qaba cudurka laf-dhabarka ee cudurka psoriasis), sida HLA-B38 iyo HLA-B39. HLA-Cw6 waxay la xiriirtaa bilawga hore ee cudurka psoriasis (ka yar 40 sano) iyo weliba cudur ka daran. HLA-B13, HLA-B17, HLA-B57, iyo HLA-Cw * 0602 ayaa badanaa ku dhaca dadka qaba cudurka "psoriatic arthritis" marka la barbar dhigo dadweynaha guud.
Meelaha soo socdo (mid ka mid ah laba nooc ama ka badan oo ah noocyo kala duwan oo hiddesid ah oo isbedel lagu sameeyo, oo laga helay isla goobta koromosoomka) ayaa lagu arkay inay si aad ah ula xiriiraan cudurka psoriasis ee arthritis marka loo eego cudurka psoriasis: B * 8, B * 27, B * 38, iyo C * 06. Waxaa sidoo kale jira HLA haplotypes (kooxo hidde ah oo laga dhaxlay hal waalid) oo lala xiriiriyo cudurka psoriasic arthritis: B * 18, C * 07, B * 27, B38, iyo B * 8.
In kasta oo HLA-B27 la yiraahdo qiimaha ugu qiimaha badan ee xanuunka psoriatic-ka ee ka dhanka ah cudurka psoriasis, maahan hubaal.
Tirada HLA-B27 waxay ka sarraysaa qiiqa ankylosing spondylitis iyo arthritis-ka marka la barbar-dhigo cudurka psoriatic arthritis. Waxaa sidoo kale muhiim ah in la xuso in dad badan oo qaba cudurka psoriasis iyo mid ka mid ah daawada spondylo-groti'yada ay tahay mid aan fiicnayn HLA-B27. Sidoo kale, dad badan oo qaba cudurka "psoriatic arthritis" oo u fiican HLA-B27 ma muujiyaan kaqeybgalka laf-dhabarka.
Daraasadaha qaarkood waxay muujiyeen xiriirka ka dhaxeeya xanuunka psoriatic arthritis iyo HLA-DR4 , antigen kaas oo loo yaqaano in uu la xiriiro rheumatoid arthritis . Hase-yeeshe, HLA-DRB1 * 0401 wax yar ayay u badan tahay dadka qaba cudurka psoriasis ee arthritis-ka ee u roon HLA-DRB1 * 04 marka loo eego dadka qaba rheumatoid arthritis.
Hase yeeshee, HLA-DRB1 * 0402, oo ah mid aad u badan oo ku dhaca cudurka "psoriasis arthritis-ka" rheumatoid arthritis. Goobaha kale ee ka tirsan gobolka MHC-da ayaa sidoo kale la soo bartay.
GWAS (Sawirada Genome-Wide Association)
Isku-darka ururada Genome-ga ah (GWAS) ayaa falanqeeya noocyada caadiga ah ee hidde-wadaha ee dadka kala duwan si loo ogaado haddii wax kala-duwanaansho la xidhiidha dabeecadda. Sida laga soo xigtay Best Practice & Research: Rheumatology Clinic (2014), 36 gen ayaa waxay gaareen muhiimadda guud ee guud ahaaneed waxaana ay ku xisaabtamayaan qiyaastii 22% helitaanka guurka cudurka psoriasis. Caadada loo yaqaan GWAS ee loo arko inay caan ku yihiin cudurka psoriasis waxaa ka mid ah HLA-Cw6, IL12B, IL23R, IL23A, TNIP1, TNFAIP3, LCE3B-LCE3C, TRAF3IP2, NFkBIA, FBXL19, TYK2, IFIH1, REL, iyo ERAP1. Gowraha ay garteen GWAS oo caan ku ah cudurka psoriasis ee arthritis-ka waxaa ka mid ah HLA-B / C, HLA-B, IL-12B, IL-23R, TNIP1, TRAF3IP2, FBXL19, iyo REL.
Khadka hoose
Haddii aad leedahay xubin qoys oo leh cudurka psoriasis ee arthritis-ka, barashada in daraasaduhu muujiyeen 55 jeer oo ka sarreeya suurtagalnimada in la sameeyo xaalada, si macquul ah, waa mid welwel leh. Isku hubso aqoonta saxda ah - laga yaabee inaad leedahay fikrado khaldan oo ku saabsan xaalada dhabta ah ee kaa caawin karta inaad si toos ah u hagaajiso, yareeyso welwelkaaga. Iyo, dabcan, wadahadal furan oo ku saabsan xirfadlahaaga daryeelka caafimaadka.
Ilaha:
Falanqaynta daraasaadka qoyaanka ee qoysaska leh nidaamyo aqoonsi oo adag. Matthews AG et al. Gobolka Med. 2008 Oktoobar 30; 27 (24): 5076-5092.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562890/
Genetics ee Arthritis. Tababarka ugu Fiican & Cilmi-baarista: Rheumatology Rugaha. O'Reilly DD et al. 2014 Oct; 28 (5): 673-85.
http://www.ncbi.nlm.nih.gov/pubmed/25488777
Caabuqa xanuunka 'Psoriatic Arthritis'. UptoDate. Gladman iyo Ritchlin. Bishii May ee sannadka 2016.
https://www.uptodate.com/contents/pathogenesis-of-psoriatic-arthritis
Genetics of Psoriasis iyo Arthritis Psoriatic. India Journal of Dermatology. V. Chandran. 2010 Apr-Juun.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887520/
Cudurka Psoriatic Arthritis. Pathogenesis. Calaamadaha Genetic. Kelley ee buugta qoraalka ee Rheumatology. Cutubka 77aad. Daabacaadda sagaalaad. Elsevier.