Maandooriyaha Isugeynta La Isugu Daray Waxyaabaha Kala Duwan ee La Yidhaahdo
Qeybinta
Odefsey waa hal kiniin ah, daawo isku dhafan oo loo isticmaalo daaweynta HIV, taas oo ka kooban saddex wakiil oo kala duwan:
- Rilpivirine , oo aan aheyn nukleoside-celin-celin-celis-celin-la'aan (NNRTI)
- emtricitabine, nucleotide celinta transcriptase inhibitor (NtRTI)
- Tenofovir alafenamide (TAF) , NtRTI kale
Odefsey waa daroogada isku dhafan ee labaad si loo isticmaalo TAF, oo ah "kobcin" version of tenofovir disoproxil fumarate (TDF) laga helay daawooyinka Truvada iyo Atripla .
Sidan oo kale, waxaa loo tixgelin karaa horumarinta Complera, oo ah hal-kiniin oo ka kooban rilpivirine + emtricitabine + TDF.
TAF waxaa loo tixgeliyaa inay ka sarreyso TDF maadaama ay awood u leedahay in ay daawada ugu firfircoon u siiso unugyada iyo qiyaaso aad u yar - macnaheedu waxa weeye in ay yaraanta daawada ku jirta dhiigga iyo in yar oo aan la helin horumarinta kaneecada la xiriira daroogada.
(Inkasta oo halista TDF-ku xirxirto sunta sunta ay tahay mid aad u hooseeya dalalka horumaray, khatartaas waxaa loo arkaa in ay si weyn u kicinayso dalalka soo koraya halkaasoo ay jirto xaalad weyn oo ka timaadda cillad kelyo horay u jirtay.
Calaamadaha daaweynta
Odefsey waxaa ansixiyay Maamulka Cuntada iyo Dawooyinka ee Maraykanka 1-dii Maarso, 2016 si loogu isticmaalo labadaba dadka waawayn iyo carruurta da'doodu ka weyn tahay 12 sano oo aan waligood ku jirin daaweynta HIV , kuwaas oo leh fayras fayrus ah 100,000 oo mitir / m ama ka yar, iyo miisaanka 77 rodol (35kg) ama ka badan.
Odefsey ayaa sidoo kale loo isticmaali karaa in lagu badalo daweynta hadda (sida kuwa Complera) haddii bukaanku uu lahaa fayras aan la ogaan karin (<50 unug / mL) ugu yaraan lix bilood, ma laha taariikhda daaweynta oo aan la ogaan, iska caabin kasta oo ka mid ah daroogooyinka qayb ka ah Odefsey.
Dejinta
Odefsey waa kiniin, miisaan, kiniin la duubay, oo ka kooban 25mg oo rilpivirine, 200mg oo emtricitabine iyo 25 mg TAF.
Waxaa ku xeeldheer "GSI" hal dhinac iyo "255" dhinaca kale.
Qiyaasta
Hal kiniin maalinle ah oo la qaato cunto. Odefsey waa in aan lagu qaadin dawooyinka kale ee daawada antiretroviral ee loo isticmaalo daaweynta HIV.
Waxyaabaha kale ee saameynaya
Dhibaatooyin dhinaca daroogada ah ayaa lagu arkay bukaanka bukaan socodka daaweynta qaadashada rilpivirine iyo / ama emtricitabine + TAF, oo ah kuwa ugu badan ee ay ahaayeen:
- Lalabbo
- Madax xanuun
- Insomnia
- Murugo
Dhibaatooyinka kale ayaa caadi ahaan soo noqnoqonaya, iyada oo tiro yar oo bukaanno ah ay joojinayaan sababtoo ah daaweynta xasaasiyadda.
Khilaafaadka
Odefsey waa in aan lagu qaadin daawooyinka soo socda:
- Daawada ka hortagga uur-qaadida: Tegretol, Trilepta, phenobarbital, phenytoin
- Daawada ka hortagga qaaxada: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Noocyada Badeecada Proton (PPIs): Nexium, Kapidex, Dexilant, Prevacid, Losec, Prilosec, Protonix, Aciphex ama wax kasta ee PPI
- Daawada steroid: Dexamethasone (xitaa waxaa laga yaabaa in la qaato qiyaasta hal mar, haddii caafimaad ahaan la tilmaamay)
- St. John Wort
Had iyo jeer la socodsii dhakhtarkaaga daroogo kasta ama kudheer, ama laguu qoro, oo laga yaabo inaad qaadato ka hor intaadan bilaabin daaweyn antiretroviral ah.
Tixgelinno Kale
Odefsey laguma talineynin bukaanka qaba naafanimada kelyaha (oo lagu qeexay inay tahay in lagu qiyaaso nadiifinta wax abuurista ee ka yar 30mL daqiiqadii).
Fadlan kugula tali dhakhtarkaaga haddii laguu daaweeyay ama lagu daaweynayo kalyo kasta ee dhakhtarka kale.
Odefsey laguma talineynin bukaanka qaba cilladda beerka ama kuwa qaba infakshanka cagaarshow B (HBV) ee daba dheeraaday sababta oo ah waxay si weyn u sii xumeyn kartaa dhibaatooyinka beerka. Waxaa lagula talinayaa in dadka qaba HIV lagu baaro HBV ka hor inta aysan qorin Odefsey. Fadlan kugula talinay dhakhtarkaaga haddii aad qabtid dhibaato beerka iyo / ama taariikhda cagaarshow.
Qaybta rilpivirine ee Odefsy waxay sababi kartaa dareen-celin aan fiicneyn oo tiro yar oo bukaanno ah, badanaaba qaabka finanka, indhaha indhaha ("pink eye"), bararka wajiga, qandhada, ama xasaasiyad kale.
Caadi ahaan, dareen-celinta dareen-celinta waxay joogtaa 1-6 usbuuc kaddib marka la bilaabayo daweynta. U sheeg dhakhtarkaaga isla markiiba calaamadahaan oo kale. Xaaladaha daran, daaweynta ayaa u badan inay u baahan tahay in la joojiyo.
Ilaha:
Reuters. "BRIEF - Gilead Sciences ayaa sheegaysa in FDA ay ogolaatay Odefsey." La sii daayay March 1, 2015.
Gilead Sciences. " Odefsey - Warbixinaha Wargelinta". Foster City, California; heley March 18, 2016.