Wax badan ka baro xayawaanka Noocyada Paenibacillus VT 400
Xilliga xagaaga 2016, kulankooda sanadlaha ah ee Bulshada Maraykanka ee Microbobiology, saynisyahanno waxay isugu soo uruuriyeen oo ay ka wada hadleen natiijooyinka la xidhiidha adduunka bakteeriyada iyo caafimaadka bini'aadamka.
Waxyaabaha laga helay, koox ayaa ku soo warramey guud ahaan genome-ga, ama qaybta dhamaystiran ee gen, oo loogu talagalay bakteeriyada loo yaqaan Paenibacillus noocyada VT 400 (PVT400). Bakteeriyadan ayaa horay looga helay calyada bukaanka cudurada carruurta ee leh 'lymphoblastic leukemia' (ALL).
Macluumaad faahfaahsan oo ka socda baadhitaankan iyo mustaqbalka ayaa ka caawin doona aqoonyahannada in ay bartaan in bakteeriyadani ay door ka qaadan karto cudurada bini-aadanka, gaar ahaan dadka qaba caleemo-ba'an oo horay ugu dhaco cudurka pneumonia ama cudurada dhiiga.
Pneumonia ee Dadka qaba Kansarka
Pneumonia waa sababta ugu wayn ee dhimashada bukaanka kansarka qaba nutropenia, iyo gaar ahaan kuwa qaba leukemia ba'an. Cudurka neutropenia waa tiro yar oo nutrophils ah oo ku jira dhiig-nudheellitiyadu waa unugyada dhiiga cad oo muhiim u ah inay caawiyaan jirka si loola dagaallamo cudurka .
Cudurrada neef-mareenka ee hooseeya ayaa aad ugu badan bukaanada kansarka, iyadoo warbixinno muujinaya in 13 ilaa 31 boqolkiiba bukaanada leukemia ee qaata daweynta kiimikada iyo ilaa boqolkiiba 80 dadka qaata unugyada xubinta taranka ee hematopoietic ayaa la kulmi doona ugu yaraan hal xannuun ee pneumonia.
Cudurka 'neutropenic pneumonia' waa cudurro halis ah oo halis ah. Meelahaas oo kale, dhakhaatiirtu waxay isla markiiba bilaabaan daaweynta antibiyootigga, iyaga oo aan sugin natiijooyinka shaybaarka si loo xaqiijiyo nooca bakteeriyada - sababtoo ah waa muhiim in la bilaabo daaweynta hal mar, si loo yareeyo khatarta bukaanku ku dhici doono cudurka.
Xaqiiqdii, daaweynta ka hortagga waxaa loo isticmaalaa duruufaha qaarkood, kuwaas oo hoos ku qoran.
Horumarka dhowaanta ee maaraynta nudaha ootropenic pneumonia ayaa rajo ka qabta natiijooyinka ka sii wanaagsan. Jaaliyado badan oo caafimaad ayaa soo saaray tilmaan-bixinno cusub oo loogu talagalay daaweynta antibiyootigga ee looga shakisan yahay oof-bararka nutropenic.
Waxaa macquul ah in wakiilada cusub ee kor u qaadaya jawaabaha jirka ee caabuqa ay sii wanaajin karaan waxqabadka antibiotics.
Diirada saarista Xanuunada Bukaan-jiifka ee Bukaan-jiifka qaba Nutropenia
Tilmaamaha ka soo jeeda bulshada American of Clinical Oncology (ASCO) waxay ku talinayaan in dhakhtarradu isku dayaan inay ka hortagaan caabuqa bukaan-socodka oo leh nutropenia qoto dheer laakiin aan qandho lahayn. Daaweynta bakteeriyada iyo antifungal ayaa lagula taliyaa haddii neutrofilayaasha la filayo inay ka hooseeyaan 100 / μL in ka badan toddoba cisho. Tilmaamuhu wuxuu dhigayaa in wakiilka la doorto ee daaweynta ka hortagga bakteeriyada uu yahay fluoroquinolone afka, halka daaweynta antifungal ay tahay afka triazole.
Bukaan-socodka qaba nutropenia waxay u nugul yihiin noocyo kala duwan oo ka mid ah cudurro badan marka loo eego kuwa ka soo horjeeda. Waxay ku caawin kartaa dhakhaatiirta in ay tixgeliyaan meesha bakteeriyadu ka timaaddo saadaalinta daawooyinka antibiyootigga ay u badan tahay inay u adkaystaan, sidaas darteed xeeladaha ay u badan tahay inay noqdaan kuwa ugu waxtarka badan.
Noocyada Paenibacillus
Dhammaadkii, aqoonyahannadu waxay baranayeen PVT400, bakteeriyada cusub ee laga soo saaro bukaanka leukemia, xubin ka mid ah Paenibacillus genus-qoys ah noocyo bakteeriyo ah. Noocyada kala duwan ee kooxdan dhexdeeda ayaa laga soocay ciidda, biyaha, dhirta, caanaha, iyo goobo kale.
Si kastaba ha noqotee, noocyada Paenibacillus looma ogeyn inay sababaan cudur bani-aadam. .. ilaa warbixinnada dhowaan muujiyey suurtagalnimada ka qaybqaadashada saddex nooc ee Paenibacillus kala duwan ee cudurrada aadanaha.
Ka dib PVT 400 waxaa laga soocay calaamadda bukaanka cudurrada carruurta ee qaba lymphoblastic lymphoblastic , baaritaanada hore waxay muujiyeen qaar ka mid ah iskudhacyadan leh noocyada amylolyticus, taas oo laga helay hindhiste xayawaan ee duulduubka; Si kastaba ha ahaatee, illaa iyo hadda, weli waa run in P. amylolyticus aan laga helin aadanaha, iyo daraasado dheeraad ah ayaa muujiyay farqiga u dhaxeeya xanuunka-VT 400 bakteeriyada laga helay bukaanka kansarka iyo P.
Ciladaha amylolyticus.
Marka, markii baarayaashu wax ka bartay dhammaan gen VT 400 genome, waxaa jiray dhowr waxyaabood oo xiiso leh. Waxay leedahay hiddo-ku-ool ah hababka iska caabinta dawooyinka kemotherabi , sida tunicamycin iyo bleomycin. Waxay sidoo kale heleen gen oo ah boogaha bakteeriyada ee la xidhiidha iska caabin badan, sidoo kale gen genes codsiga antibiyootiko, oo ay ku jiraan vancomycin, fosmidomycin, tetracycline iyo sidoo kale daawooyinka penicillin-sida, ama beta-laktams.
Qorayaashii baadhitaanka hidde-sidan-buuggani wuxuu xusay in taxanaha buuxa ee genomeabacillus sp. Cadaadiska VT 400 wuxuu gacan ka geysan doonaa sidii loo ogaan lahaa doorka Paenibacillus ee cudurrada bini-aadamka iyo bixinta aragti ku saabsan habka bakteeriyada caadiga ah ee ku nool bukaanka qaba kansarka dhiigga.
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