Cudurka 'lymphocytic leukemia' (CLL) waa nooca ugu badan ee leukemia ee dadka qaangaarka ah ee dalalka reer galbeedka. Waxay dhacdaa marka ay waxyeello gaarsiisan tahay qalabka hidde-gelyada (unugyada) ee unugyada kuwaas oo sida caadiga ah ku dhacaya nooc unugyada dhiigga cad ee loo yaqaan 'lymphocyte'.
CLL way ka duwan tahay noocyada kale ee leukemia sababtoo ah isbadelka hidde-yada kaliya ma keeno koritaan aan xakameynin ee lymphocytes ee dhuuxa, laakiin waxay sidoo kale keentaa unugyada aan raacin qaabka caadiga ah ee dhimashada unugyada dabiiciga ah.
Tani waxay keenaysaa tirada sii kordheysa ee lymphocytes ee dhiigga.
Qiyaastii 95% xaaladaha CLL ee galbeedka, nooca lymphocyte ee uu saameeyey waa B-lymphocyte (B-cell CLL). T-cell CLL wuxuu ku badan yahay meelaha Japan iyo kaliya xisaabaadka qiyaastii 5% kiisaska Maraykanka
Lymphocytes aan caadi aheyn ee leetemia joogto ah ayaa ka weyn tan kuwa lagu arkay leetemia daran. Sababtoo ah iyagu waa kuwo qaangaar ah, waxay awoodaan inay qabtaan shaqooyin badan oo ah qanjidhada caadiga ah. Taas waxaa sabab u ah, leetemia ba'an oo aan la daaweyn karin mudo dheer ka hor inta bukaanku uu dareemayo wax calaamado ah.
Waxaa jira waqtiyo marka qof caafimaad leh uu yeelan karo tirakoob lymphocyte, tani macnaheedu maaha inay qabaan leetemia. Unugyada infekshannada infekshanku waxay si caadi ah u galaan heerarka wax-soo-saarka ee waqtiyada cudurka. Marka la eego CLL, korodhka nooc ka mid ah nooca lymphocyte ayaa dhacaya (iyadoo ku xiran halka isbedelka hidde-celinta asal ahaan ka dhaceen) iyo unugyada, inta ay qaan gaarayaan, muujiyaan sifooyin aan caadi ahayn.
Shaqada muhiimka ah ee Lymphocytes ee jirka ku jira waa in la soo saaro immunoglobulin, kuwaas oo ah borotiinno caawiya inay la dagaallamaan cudurka. Marka la eego CLL, lymphocytes aan caadi ahayn ma awoodaan inay soo saaraan immunoglobulin (ama "antibodies") oo si haboon u shaqeynaya sidoo kale waxay ka hortagayaan lymphocytes non-kansar aan laga soo saarin antibodies.
Sidaa darteed, dadka qaba CLL badanaaba waxay qabaan infekshin joogto ah.
Calaamadaha iyo Calaamadaha
Bukaanjiifka qaar, CLL waa mid aad u gaabis ah, calaamadaha waxaa laga yaabaa in ay noqdaan kuwo aan la garan karin. Xitaa marka ay tirada lymphocytes ay gaarto heerarka sare ee dhiigga, badanaa ma saameynayaan wax soo saarka unugyada kale ee unugyada dhiiga sida unugyada cas iyo qajaarka.
Bukaannada leh noocyo badan oo ka mid ah xanuunka CLL ama kuwa leh cudurrada ugu sareeya waxay muujin karaan calaamadaha culeyska saaridda lafta lafaha ee noocyada unugyada kale iyo sidoo kale astaamaha la xiriira qanjidhada waaweyn.
Bukaannada CLL waxaa dhici karta in ay la kulmaan:
- Miisaanka culus
- Dareen guud ahaan "diyaarsan"
- Dhidid habeenkii ah
- Dareen daal badan oo aan la seexin hurdo wanaagsan habeenkii
- Qanjirada qanjidhada oo barara
- Caabuqyo joogto ah
- Xanuun ka yimaada cadaadiska qanjidhada qanjirada ee xarumaha ku wareegsan
- Dhibaatooyinka dhimashada
Calaamadahaasi waxay sidoo kale noqon karaan calaamadda xaaladaha kale ee aan halis ahayn. Haddii aad ka walwalsan tahay isbeddel kasta oo caafimaadkaaga ah, waa inaad ka raadsataa dhakhtarkaaga.
Maqnaanshaha CLL Leukemia ama Lymphoma?
Lymphocytic leukemia iyo lymfoma waxay labaduba dhacaan marka lymphocytes ay ku dhuftaan si aan toos ahayn. Xaaladaha labaduba waxay yeelan karaan barar ku dhaca qanjirada nudaha waxayna labaduba muujin karaan lymphocytes xad dhaaf ah ee dhiigga.
Dhab ahaan, farqiga u dhexeeya labadan cudur ayaa ugu horreyn ku leh magaca kaliya.
Bukaan-socodka ayaa la sheegay inuu qabo CLL marka ay qabaan dheecaan badan oo dheecaan ah oo wareegaya iyo barar yar ee noodhka. Taa bedelkeeda, bukaanjiifka leh noodhadh aad u ballaaran, laakiin u dhowaanta caadiga ah ee unugyada caddaanka ah ee ku jira dhiigga ayaa lagu qeexaa inuu qabo lymphocytic lymphoma (SLL), nooc ka mid ah non-Hodgkin lymphoma.
Xaalado badan, ereyada CLL iyo SLL waxaa loo isticmaalaa isbeddel ahaan maadaama ay yihiin asal ahaantii isla cudurkii lagu soo bandhigay qaab kale.
Waxyaabaha Halista ah
CLL waxay u egtahay in uu noqdo leukemia shakhsiyaadka waayeelka ah, iyadoo celcelis ahaan da'da qiyaasta cudurka uu yahay 65 jir.
Boqolkiiba 90 dadka lagu yaqaan CLL waxay ka weyn yihiin da'da 40 sano.
Si la mid ah noocyada kale ee leukemia, saynisyahadu ma ogaanayaan waxa dhabta ah ee CLL, laakiin waxaa jira dhowr arrimood oo u muuqda in ay dadka qaarkiis halis ugu sareeyso inay horumariyaan:
- Ku dhicida kiimikooyinka sunta ah qaarkood, sida cayayaanka iyo cayayaanka
- Caabuqa bakteeriyada qaarkood ama fayrasyada sida fayraska T-linphocytotropic (HTLV-1)
- Qaadashada qaraabada heerka koowaad ah, sida walaalaha, ee CLL waxay kordhin kartaa khatarta sadex ilaa afar jeer
Si ka duwan sida noocyada kale ee leukemia, shucaac soo noqnoqoshadu uma muuqato inay tahay arrin khatar ah.
Inkastoo arrimahan ay kordhin karaan suurtogalnimada in qofku helo CLL, dad badan oo qaba xaaladdahan halista ah waligood ma helayaan leetemia, qaar badan oo qaba leetemia wax khatar ah ma leh.
Soo-soo-kabashada
CLL wuxuu dhacaa marka dhaawac ku yimaado DNA-ga unugyada oo sababaya iskudhufin aan la xakamayn iyo faa iido badan oo lymphocytes ah. Tani waxay keeni doontaa tiro badan oo lymphocytes ah wareegga dhiigga, kaas oo sidoo kale laga qaadi karo qanjirada noodhka. Xaaladaha intooda ugu badan, dadka qaba CLL waxay muujinayaan calaamado yar maadaama ay cudurku aad u gaabin karo horumarka.
Ilaha:
Chirorazzi, N., Rai, K., Ferrarini, M. "Mechanism of Disease: Lymphocytic Leukemia." New Journal of Medicine 2005; 352: 804-15.
Lin, T., Byrd, J. "Leukemia Lymphocytic Leukemia Chronic Lymphocytic and Related Chronic Leukemias" ee Chang Chang, A., Hayes, D. Pass, H. et al. eds. (2006) Onkologi: Cabbiraad ku Salaysan Caqli-ku-saleysan : New York. pp. 1210-1228.
Hillman, R., Ault, K. (2002) Jeermiska Cilmi-baadhista ee 3-aad. McGraw-Hill: New York.
Zent, C., Kay, N. "Lymphocytic Leukemia: Biology iyo Daaweynta Xaadir ah" Warbixinnada Cudurrada Qaranka ee 2007; 9: 345-352.