Uloric (febuxostat) waxaa ogolaaday FDA US Fift Feb 13, 2009. Uloric ayaa ahayd doorashadii ugu horeysay ee daaweynta ee 40 sano jirada loogu talagalay bukaannada qaba hyperuricemia iyo gout, sida laga soo xigtay Takeda Pharmaceuticals North America, Inc.
Uloric waa daroogo loo isticmaalo maaraynta daba dheeraatay ee hyperuricemia ee gout. Uloric waxay hoos u dhigtaa heerarka serum uric acid by blocking oxygase xanthine -kaasta ka masuul ah wax soo saarka uric acid.
Qanjirka 'Xanthine oxidase' wuxuu jebiyaa hypoxanthine (oo ah dheef-shiid kiimikaad-dabiiciga ah) ee xanthin, ka dibna loo yaqaano uric acid.
Sidee loo maamulaa Uloric?
Qiyaasta la oggol yahay ee Uloric waa 40 mg iyo 80 mg oo la siiyo hal mar maalin kasta. Uloric waa daawo afka ah (afka laga qaato). Talaalka bilowga ee lagu taliyey Uloric waa 40 mg maalintii. Kordhinta ilaa 80 mg ayaa lagu talinayaa bukaannada aan gaarin xajiin ah asal acid oo ka yar 6 mg / dL laba toddobaad kadib qiyaasta 40 mg. Uloric waxaa laga yaabaa in la qaato ama aan cunto lahayn mana jiraan wax talooyin ah oo ka hortagaya isticmaalka antacids. Looma baahna daawo qiyaas ah oo loogu talagalay dadka bukaanka ah ee leh cillado fudud ama mid dhexdhexaad ah ama mid naafo ah.
Waxqabadka ku jira tijaabooyinka caafimaadka
Xanuunada kiliinikada, qiyaasta sare ee Uloric ayaa lagu ogaadey inay ka waxtar badan tahay daawada placebo ama qiyaasta caadiga ah ee allopurinol - daawada kale ee loo isticmaalo daaweynta hyperuricemia. Sidoo kale, marxaladda 6-bilood ee tijaabada III-boqolkiiba bukaanka bukaanka, oo hoos u dhigay heerarkooda uric acid ilaa heerarka la rabo ee ka hooseeya 6, ayaa aad uga sareeya kuwa qaata 80 mg marka loo eego kuwa qaata 40 mg Uloric.
Saameynada iyo Digniinta
Uloric laguma talinayo dadka qaba asymptomatic hyperuricemia. Uloric waa in aan loo isticmaalin dadka horey loogu daaweyn jiray daawada azathioprine (Imuran), mercaptopurine, iyo teofillin.
Iyadoo ku saleysan saddex daraasad oo kiliinikaro ah, baaritaan kiliinikada la xakameeyay, beerka oo aan caadi ahayn, lallabo, arthralgia, iyo firiiricu waa dareen-celinta ugu caansan ee ku dhaca ugu yaraan 1% bukaanka lagu daaweeyo Uloric iyo ugu yaraan 0.5%
Sidoo kale, marka la barbardhigo allopurinol, Uloric wuxuu la xidhiidhaa dhacdooyin badan oo ka mid ah dhacdooyinka wadnaha iyo xididada wadnaha, laakiin xiriirka tooska ah lama xiriirin. Xasaasiyadda hawlaha beerka ayaa ah waxyeellada ugu caansan ee keenta ee keenta joojinta Uloric.
Waxaa jirey warbixinno xaashiyo ah oo ku saabsan fashil la'aanta xanuunka, dhimashada iyo dhimashada, bukaanka lagu daaweeyo Uloric. Warbixinnadu ma aysan haynin xog ku filan si loo abuuro sabab macquul ah.
Korodhka cirridka gawaarida badanaa waa la kulmaa marka walxaha anti-hyperuricemic la bilaabay. Taas waxaa ka mid ah Uloric. Haddii uu googo faleebo ah oo la xidhiidha bilaabidda daaweynta Uloric, daawada uma baahna in la joojiyo. Si looga hortago calaamadaha gawaarida ee la xidhiidha bilaabista daaweynta Uloric, NSAID ama colchicine ayaa la qaadan karaa si joogta ah. Kororka qulqulka gawraanka ayaa loo sababeeyay hoos u dhigidda heerarka serum uric acid, taas oo, taasi waxay keenaysaa, in dhaqdhaqaaqa kaadida laga soo saaro kaydka unugyada.
Dumarka uurka leh ma jirin daraasado si fiican loo xakameeyo Uloric. Uurka, Uloric waa in la isticmaalaa oo kaliya haddii faa'iidada la filayo inay ka sii daran tahay khatarta ugu imaan karta uur-jiifka. Sidoo kale, lama ogaan karo haddii Uloric laga saaro caanaha aadanaha.
Dumarka ku xanaaneeya waa in ay taxadaraan.
Ammaanka iyo waxtarka Uloric ee carruurta ka yar 18 sano lama yaqaan.
Ilaha:
Macluumaadka Daawada Uloric. Uloric.com. Takeda Pharmaceuticals Inc. Revised March 2013.
FDA Waxay ogolaataa ULORIC® (febuxostat) ee Maaraynta Xanuunka Hyperuricemia ee bukaanka qaba Gout. Takeda Pharmaceuticals. Febraayo 13, 2009.