Chemotherapy Cytotoxic iyo Aaladaha kale ee Cytotoxic ah
Cytotoxic wuxuu loola jeedaa walax ama nidaam taasoo keenta dhaawac cell ama dhimasho unug. Qodobka "cyto" waxa loola jeedaa unugyada iyo "sunta" sunta.
Dawooyinka Chemotherapy ee Kombiyuutarka
Inta badan ereyga "cytotoxic" waxaa loola jeedaa saameynta dawada kemotherabi ay leedahay unugyada kansarka . Dareenkan, wakiil cytotoxic ah ayaa laga yaabaa in laga gooyo mid ka mid ah cytostatic.
Daawada cytostatic, waxay u dhigantaa, in la joojiyo qaybinta unugyada iyo korniinka, laakiin ma keeni lahaa dhimashada unugga si toos ah.
Daawooyinka mukhadaraadka waxaa lagu shaqeeyaa iyadoo la dhexgalo unugyada meelaha gaarka ah ee wareegga koritaanka. Daawooyinka mukhadaraadka waxaa ugu badan inay saameyn ku yeeshaan unugyada sii kordhaya, tusaale ahaan, unugyada kansarka, timaha timaha, dhuuxa lafta iyo unugyada dhiifeysan ee caloosha iyo mindhicirka. Sababta ugu badan ee kiimoteraabiyada loo isticmaalo daawooyinka isku dhafan iyo in badanaa wareegyada kemotherabi waa soo noqnoqonayaan sababta oo ah unugyada ayaa ku jira meelo kala duwan oo ka mid ah habka qaybinta.
Agentotic Agent
Waxaa jira walxo kale oo cytotoxic ah oo loo isticmaalo tiro ballaaran oo shaqooyin ah. Sida dawooyinka kemotherabi ee cytotoxic, tani macnaheedu waa inay dilaan unugyada.
Unugyada Cytotoxic T
Waxyaabaha loo yaqaanno Cytotoxic ma ahan uun in la burburiyo kansarka iyo xakameynta cudurrada. Jidhkeenu wuxuu kaloo soo saaraa unugyada cytotoxic T-cells (cytotoxic T lymphocytes). Unugyada Cytotoxic waa qeyb ka mid ah habka difaaca jirka, oo baadhaya, raadiya oo burburiya unugyada ay qaadaan fayrasyada iyo sidoo kale unugyada kansarka.
Mid ka mid ah meelaha ugu sahlan ee horumarinta cilmi baarista kansarka ayaa haatan diiradda saaraya kobcinta iyo kicinta unugyada cytotoxikada ee gaarka ah si loola dagaallamo kansarka jirkeena.
Venetoksic Venom
Aadanuhu kali kali maaha isticmaalka unugyada cytotoxiga T. Xanuunnada qaar, sida kuwa ka soo jeeda jilayaasha, cobras iyo caarada jilicsan, sidoo kale waa cytotoxic.
Mashruuca Hawlaha
Sumosoomiyeyaasha kiimikada waxay ku dili karaan unugyada dhowr siyaabood. Waxay waxyeelleyn karaan unugyada si ay xuubka unuggu u daciifiyo unuguna jabo (lysis,) ama waxay farageliyaan qaybta unugyada si markaa unuggu joojiyo koritaanka iyo qaybinta.
Khatarta Mukhaadaraadka Daroogada iyo Wakiilada
Daawooyinka mukhadaraadka ah waxay dili karaan unugyada kansarka laakiin waxay sidoo kale dhaawici karaan unugyada caadiga ah, kuwa caafimaad qaba.
Cytotoxic vs Genotoxic
Waxaa jira wareer badan oo u dhexeeya ereyada cytotoxic iyo genotoxic. Ereyga "cytotoxic" waxaa loola jeedaa awooda maaddo si ay u dhaawacdo unugyada. Ereyga "genotoxic" waxaa loola jeedaa awooda walaxda si toos ah u dhaawacaysa DNA-da unugyada.
Carcinogenicity / Mutagenicity
Qaar ka mid ah qeexitaano kale ayaa muhiim u ah inay sharxaan markaad ka hadlaysid cytotoxicity. Kuwaas waxaa ka mid ah:
- Kansar-ku - Kaadida maadada cytotoxic waxay leedahay awood u yeelashada inay waxyeello u gasho DNA taasoo ugu dambeyntii horseedi karta horumarinta kansarka.
- Mutagenic - Marxaladaha maaddada cytotoxic waxay u badan tahay inay u dhimi karaan koromosoomyada ilmaha caloosha ku jira.
Tani waa sababta ay aad muhiim ugu tahay dadka inay taxadaraan taxadar marka ay la tacaalayaan mukhaadaraadka iyo walaxaha.
Taxadaraadka Cytotoxic
Kuwa u shaqeeya daawooyinka cytotoxic ama walaxyo kale, taxadar ayaa lagu talinayaa gaar ahaan si looga fogaado kansarka iyo mutagenicity.
Tallaabooyinka taxadarka gaarka ah way kala duwanaan doonaan si weyn oo ku saleysan habka looga hortagi karo suurtagalnimada laakiin waxaa ku jiri kara:
- Gacmo-gashi, oo ay ku jiraan naqshado gacmo-galis ah
- Dharka gacmo dheer
- Qodobo la isku tuuray
- Muraayadaha ammaanka
- Ilaalinta neefsashada
Ilaha:
Machadka Teknolojiyada California. Tilmaamaha Isticmaalka Dawooyinka Cytotoxic iyo Chemotherapeutic. Maarso 2011. https://www.safety.caltech.edu/documents/33-cytotoxic_drugs_guidelines.pdf