Angiogenesis iyo Waxyeelayaasha Ka-hortagga Daaweynta Kansarka
Qeexitaanka: Angiogenesis
Angiogenesis waxaa loola jeedaa sameynta xididdada dhiigga ee cusub ee jirka. Waa nidaam caadi ah oo jidheed ee bogsashada, laakiin sidoo kale wuxuu ka ciyaaraa doorka koritaanka kansarka.
Angiogenesis ee Caafimaadka iyo Bogsiinta
Angiogenesis waa nidaam caadi ah oo ka dhaca jirka oo dhan xaalad kasta oo koritaanka xididdada dhiigga ee cusub loo baahan yahay.
Sidaa daraadeed, waxaa lagama maarmaan ah in carruurtu koraan, xuubka uterineinka si ay u koraan bil kasta haweenka premenopausal, iyo nabarrada si ay u bogsadaan.
Angiogenesis ee Kansarka iyo Metastasis
Angiogenesis waa xiiso u qabo kansar sababtoo ah kansarrada waxay u baahan yihiin sameynta xididdada dhiigga ee cusub si ay u koraan oo u qiyaasaan. Si kansarrada ay u koraan in ka badan hal millimitir (1 mm) angiogenesis waxay u baahan tahay inay dhacdo. Kansarradu waxay sidaan u sameeyaan iyagoo sifeynaya walxaha ku kicinaya angiogenesis, halkan, koritaanka kansarka.
Marka laga soo tago in ay tahay geedi socod loogu baahan yahay kansarrada si ay u koraan oo u galaan unugyada deriska ah, waxaa lagama maarmaan u ah inay metastasisku dhacdo . Si unugyada kansarku ay u safraan oo u dhisto guri cusub meel ka baxsan asalkooda, unugyadaasi waxay u baahan yihiin inay keenaan maadooyin dhiig oo cusub si ay u taageeraan koritaanka goobahooda cusub.
Cudurka Angiogenesis iyo Cudurka Vascular Endothelial (VEGF)
Maydhayaasha dhiigga waxay ka samaysan yihiin unugyo loo yaqaan 'endothelial cells' gudaha gudaha maraakiibta.
Maadooyinka loo yaqaanno raadinta xajmiga xididada dhiigga, VEGF gaaban, waxay u adeegaan calaamad muujinaysa unugyada endogen-ka ee koritaanka iyo abuurida xididdada dhiigga cusub. Si kale haddii loo dhigo, waxay yihiin hawlgalayaasha. Samaynta xididdada dhiigga ee jirka, sida hawlaha badan, waa dheellitiridda firfircoonida iyo xakamaynta waxtarka.
Ka hortagga Angiogenesis
Kaararka Angiogenesis waa nooc ka mid ah daawooyinka loo isticmaalo , taas oo micnaheedu yahay inay si gaar ah u bartilmaameedsanayaan unugyada kansarka ama unugyada muhiimka u ah koritaanka ama faafidda kansarka.
Daawooyinkani waxay faragelin karaan nidaamka angiogenesis meelo badan oo kala duwan. Qaar ka mid ah kuwaani waa kuwa xakameynaya iyada oo lagu xakameynayo isugeynta xanuunka dareenka dareenka (VEGF) si aanay u calaamadin karin unugyada endothelial si ay u koraan, sidaas darteed waxay joojiyaan samaynta xididdada dhiigga ee cusub.
Tusaalooyinka ka hortagga Angiogenesis
Qaar ka mid ah celiyeyaasha angiogenesis ee hadda jira ee daaweynta kansarka waxaa ka mid ah:
- Avastin (bevacizumab)
- Nexavar (sorafenib)
- Sutent (sunitinib)
- Codbixiye (pazopanib)
- Afinitor (abidkiis)
Wax dheeraad ah ka baro immunotherapy iyo sida xanuunka angiogenesis u shaqeynayaan si loo daaweeyo kansarka.
Cudurka Dabaysha ee Anjiyogenesis Plus
Su'aal caadi ah waa sababta ay dadku ugu baahan yihiin kiimoteraabiga marka lagu daro xanuunka angiogenesis. U fiirsashada habka anjiogenesis-ka u shaqeynayo waxay ka caawisaa inay sharraxdo tan. Cudurka kansarka Angiogenesis maaha dilida kansarrada, waxay si fudud u shaqeeyaan si looga hortago inay sii korodhaan iyo faafitaanka (faafinta), si looga takhaluso buro, chemotherapy waa in loo isticmaalo in lagu daro carqaladaha angiogenesis.
Waxyeelooyinka Hadafka ah ee Ka-hortagga Angiogenesis
Marka la joojiyo angiogenesis-ka horay loo ogaaday sida daaweynta kansarka, waxaa loo maleynayay in ay yeelan doonaan saameyno yar.
Taasi ma ahayn arrin. Sida chemotherapy waxyeello u keento unugyada caadiga ah (tusaale ahaan, joojinta qaybta unugyada timaha timaha, dhuuxa lafaha, iyo xuubka caloosha) Angiogenesis inhibitorku waxay sidoo kale keeni karaan saameyno la xidhiidha waxqabadyadooda ku jira unugyada caafimaadka qaba iyo unugyada. Qaar ka mid ah waxyeelooyinka guud ee caadiga ah waxay la xiriiraan:
- Dhibaatada boogta oo aan caadi ahayn tan oo ah unugyada angiogenesis oo kaliya ma faragelin kartida awoodda unugyada kansarka inay sameeyaan marinnada dhiigga ee cusub, laakiin sidoo kale waxay farageliyaan awoodda unugyada caafimaadka leh si ay u sameeyaan marinnada dhiigga cusub si ay u bedelaan dhaawac.
- Xinjirta halbowlayaasha, taas oo markaa u horseedi karta weerarrada wadnaha iyo istaroogga.
- Cadaadis dhiig oo sarreeya.
Mustaqbalka / Dacwadaha Daaweynta
Daawooyinka badan ee qaybtan ayaa lagu qiimeeyaa tijaabooyinka bukaan socodka, waxaana jira rajo ah in weerarka kansarka looga soo horjeedo faragelinta angiogenesis uu noqon doono qayb ka mid ah hababka daweynta kansarka ee mustaqbalka.
Ilaha:
Bulshada Mareykanka ee Oncology. Cancer.Net. Angiogenesis iyo Angiogenesis Inhibitors si loo daaweeyo Kansarka. 07/2014. http://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/angiogenesis-and-angiogenesis-inhibitors-treat-cancer
Machadka Kansarka Qaranka. Ka hortagga Angiogenesis. La daabacay 10/07/11. https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/angiogenesis-inhibitors-fact-sheet